A5071262580- Inflammatory Bowel Disease
- Microscopic Colitis
- Pregnancy and Medication Impact
- Helicobacter pylori-related gastroenterology studies
- Reproductive System and Pregnancy
- Eosinophilic Esophagitis
- Autoimmune and Inflammatory Disorders Research
- Immunodeficiency and Autoimmune Disorders
- Child and Adolescent Health
- Adolescent and Pediatric Healthcare
- Celiac Disease Research and Management
- Clinical Nutrition and Gastroenterology
- Acute Lymphoblastic Leukemia research
- Neonatal Respiratory Health Research
- Digestive system and related health
- Infant Nutrition and Health
- Pediatric health and respiratory diseases
- Dermatology and Skin Diseases
- Liver Diseases and Immunity
- Pediatric Pain Management Techniques
- Polyomavirus and related diseases
- Intestinal Malrotation and Obstruction Disorders
- Inflammation biomarkers and pathways
- Pharmaceutical studies and practices
- Diet and metabolism studies
Charles University
2013-2025
University Hospital in Motol
2016-2025
Opća bolnica Karlovac
2024
Unité de Nutrition Humaine
2017
Evidence of the impact in utero exposure to anti–tumor necrosis factor (TNF)–alpha on long-term childhood development is limited. The aim was assess anti-TNF-alpha due mothers' inflammatory bowel disease (IBD) postnatal exposed children. We included consecutive children (≥12 months age) born mothers with IBD (2007–2016) treated during pregnancy 3 centers Czech Republic. A control group comprised unexposed non-IBD undergoing mandatory check-ups at general pediatricians' offices. Data...
The aim was to explore factors associated with intestinal tissue levels of anti-TNF alpha (anti-TNF), antibodies, and cytokines in pediatric patients Crohn Disease (CD). In a prospective exploratory study CD undergoing ileocecal resection or colonoscopy between 6/2020 1/2023, we analysed anti-TNF, (TNF-α, IL-17, IL-1β, IFN-γ) from biopsies. Mixed-effects regression models, adjusted for potential confounders, were used. Data 27 (18 females, 66.7%) analysed. Fourteen (52%) received adalimumab...
Inflammatory bowel diseases (IBD) are associated with altered bone health and increased risk for fractures. Vitamin D deficiency is frequently found in IBD; however, the effect of vitamin supplementation on children IBD poorly understood. We aimed to observe changes volumetric density dynamic muscle functions after substitution a cohort pediatric patients IBD. This was prospective observational study 55 (aged 5–19 years) Bone quality assessed using peripheral quantitative computed tomography...
ABSTRACT Background: Interferon‐γ release assay (IGRA) is widely used for screening of latent tuberculosis (TB) before and during biological therapy (BT). An indeterminate result IGRA represents a limitation in the management inflammatory bowel disease (IBD). Data on factors influencing results are scarce children. The aim study was to identify children with IBD. Methods: Seventy‐two IBD (59 Crohn disease, 11 ulcerative colitis, 2 IBD‐unclassified) indicated BT were tested TB infection...
The outcome of patients with Crohn's disease who failed anti-tumor necrosis factor alpha (anti-TNFα) therapy despite adequate serum drug levels (pharmacodynamic failure) is unclear. We aimed to assess such pediatric underwent intestinal resection and were re-treated the same anti-TNFα agent postoperatively.Pediatric treated agents postoperatively assessed retrospectively. Patients stratified those preoperative pharmacodynamic failure no treatment.A total 53 children included, 18 35 controls....
<b><i>Background:</i></b> In adults, infliximab (IFX) levels correlate with disease activity, and antibodies to IFX (ATIs) predict treatment failure. We aimed determine the association of ATIs activity in a paediatric population. prospectively collected blood, stool, clinical data from 65 patients (age 10.5-15.1 years) Crohn's (CD) before administration, measured trough levels, ATIs, faecal calprotectin (CPT). Samples were during maintenance therapy. used multivariate...
INTRODUCTION: Two antitumor necrosis factor therapies (infliximab [IFX] and adalimumab [ADA]) have been approved for the treatment of pediatric Crohn's disease (CD) but not compared in head-to-head trials. The aim this study was to compare efficacy safety ADA IFX by propensity score matching a prospective cohort patients with luminal CD at least 24-month follow-up. METHODS: Among 100 patients, 75 met inclusion criteria, 62 were matched score. We evaluated time escalation as primary outcome...
Intestinal surgery is an important part of Crohn disease (CD) treatment in children. The aim the present study was to compare rate endoscopic recurrence at sixth month after ileocecal resection (ICR) children with CD treated azathioprine between patients who received prior antitumor necrosis factor alpha (anti-TNF-α) therapy and those were not administered this therapy. Moreover, we tried identify potential risk factors for describe schedule long-term follow-up surgery.We prospectively...
Abstract Background Despite advancements, understanding the tissue pharmacokinetics of Anti-tumour necrosis factor alpha monoclonal antibodies (aTNF) and addressing cases primary non-response, secondary loss response, unexplained treatment failures in some patients pose ongoing challenges. The aim this study was to investigate factors associated with intestinal levels aTNF, anti-drug cytokines paediatric Crohn's Disease (CD). Methods A prospective CD treated who underwent ileocecal resection...
Abstract Background Data on the outcomes of advanced therapy in paediatric patients with ulcerative colitis (UC) and their predictors are scarce. We aim to assess association between remission at one year treatment pre-specified predictors, including types therapy. Methods Using Czech national prospective registry biologic innovative IBD (CREdIT), we identified 207 courses among UC patients. Disease was defined as Paediatric Ulcerative Colitis Index below 10 points. In this preliminary...
V léčbě některých gastrointestinálních onemocnění u dětí se stále častěji využívají dietní opatření založená na vyloučení některé ze skupiny fermentabilních oligosacharidů, disacharidů, monosacharidů a polyolů stravy (low-FODMAP dieta). Následující text shrnuje podstatná doporučení užití diety s nízkým obsahem FODMAP vychází stanoviska Evropské společnosti pro gastroenterologii, hepatologii výživu (ESPGHAN) vydaného v září roku 2022. Sdělení obsahuje kromě dostupné evidence také týkající...
Detection of possible predictive factors endoscopic recurrence after ileocecal resection in Crohn's disease could be very beneficial for the individual adjustment postoperative therapy. The aim this study was to verify, whether immunohistochemical detection calprotectin margins is useful diagnostics recurrence.In we included pediatric patients with who underwent resection, regardless pre-operative or post-operative therapy (n=48). We collected laboratory, clinical, surgical, and...
Background: The outcome of crohn's disease (CD) patients who failed anti-TNFα therapy despite adequate serum drug levels (pharmacodynamic failure) is unclear. We aimed to assess such pediatric underwent intestinal resection and were re-treated with the same agent post operatively. Methods: Pediatric CD treated agents post-operatively assessed retrospectively. Patients stratified those pre-operative pharmacodynamic failure no treatment. Results: A total 61 children included, 21 40 controls....
There has already been a solid evidence on safety of anti-TNFa therapy foetal development and newborn outcome. However, there is still lack data impact the treatment long-term evolution exposed children. Our aim was to assess in utero exposure due mothers’ inflammatory bowel disease (IBD) infectious risk during first year life We prospectively included consecutive children (≥12 months age) born mothers with IBD (2007–2016) treated pregnancy three medical centres Czech Republic. A control...
Anti-TNFα therapy is increasingly used during pregnancy for women with inflammatory bowel disease (IBD). Thus, the knowledge on long-term evolution of exposed children, including response to vaccinations crucial. A recent study demonstrated an adequate two non-live vaccines in 71% and 80% infants.1 Our aim was assess impact anti-TNFa exposure utero maternal IBD serologic children. We prospectively included consecutive children (≥12 months age) born mothers (2007–2016) treated three medical...