A5032827482- Clostridium difficile and Clostridium perfringens research
- Antibiotic Resistance in Bacteria
- Phenothiazines and Benzothiazines Synthesis and Activities
- Cancer therapeutics and mechanisms
- Gastrointestinal disorders and treatments
- Gastric Cancer Management and Outcomes
- Target Tracking and Data Fusion in Sensor Networks
- Glioma Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Nosocomial Infections in ICU
- Human-Automation Interaction and Safety
- Inflammatory Bowel Disease
- Cognitive Science and Mapping
- Diagnosis and treatment of tuberculosis
- Genetic factors in colorectal cancer
- Esophageal Cancer Research and Treatment
- Diverticular Disease and Complications
- Eosinophilic Esophagitis
- RNA regulation and disease
- Microbial Natural Products and Biosynthesis
- Esophageal and GI Pathology
- Cytomegalovirus and herpesvirus research
- Neurological diseases and metabolism
- Gastrointestinal Bleeding Diagnosis and Treatment
- Biochemical and Molecular Research
Rutgers, The State University of New Jersey
2024
Tufts Medical Center
2024
Johnson University
2024
Brown University
2018-2020
Rhode Island Hospital
2019
Providence College
2019
AstraZeneca (United States)
2011-2017
Cornell University
2015
New York Hospital Queens
2015
Presbyterian Hospital
2015
Goals: We investigated the long-term efficacy and safety of fecal microbiota transplant (FMT) for treatment recurrent Clostridioides difficile infection (rCDI). Background: FMT has emerged as a promising therapy patients with rCDI unresponsive to standard medical therapy, though data are scarce. Materials Methods: A multicenter retrospective study was performed on treated ≥6 months clinical follow-up post-FMT. Patients were contacted document sustained efficacy, potential adverse events,...
Inhibitors of 4'-phosphopantetheine adenylyltransferase (PPAT) were identified through high-throughput screening the AstraZeneca compound library. One series, cycloalkyl pyrimidines, showed inhibition PPAT isozymes from several species, with most potent enzymes Gram-positive species. Mode-of-inhibition studies Streptococcus pneumoniae and Staphylococcus aureus demonstrated representatives this series to be reversible inhibitors competitive phosphopantetheine uncompetitive ATP, binding...
The enantioselective synthesis of two novel cyclopropane-fused diazabicyclooctanones is reported here. Starting from butadiene monoxide, the key enone intermediate 7 was prepared in six steps. Subsequent stereoselective introduction cyclopropane group and further transformation led to compounds 1a 1b as their corresponding sodium salt. great disparity regarding hydrolytic stability rationalized by steric interaction between cyclopropyl methylene urea carbonyl. These β-lactamase inhibitors...
Abstract Ureaplasma species (spp.) are common colonizers of the urogenital tract but may cause systemic infection in immunocompromised patients. They release significant amounts ammonia via urea hydrolysis and have been recently implicated pathogenesis hyperammonemia syndrome after organ transplantation. We describe a unique case kidney transplant caused by U urealyticum infection, first, to our knowledge, fluoroquinolone‐resistant strain causing syndrome. A 17‐year‐old female developed...
We identified the prevalence and subtype of colorectal neoplasia removed during index screening colonoscopies in a large Asian American population. Americans are fastest growing demographic group United States yet there is paucity data on characteristics found this cohort. Cross-sectional study 2208 performed average-risk White patients at large, tertiary academic center. Patients were via diagnostic or procedure codes between 2015 2020, with retrospective classification polyp...
ABSTRACT Perforation after endoscopic cryoablation is a rare but serious complication. We present middle-aged male patient who presented for an elective session of his Barrett esophagus with high-grade dysplasia. After cryoablation, the complained abdominal pain, and abdomen became distended tympanic. Computed tomography showed pneumomediastinum, pneumoperitoneum, pneumoretroperitoneum no evidence extraluminal contrast extravasation. The was treated antibiotics had complications. To our...
Introduction: Fecal microbiota transplantation (FMT) is recommended treatment for recurrent C. difficile infection (CDI). Though an abundance of short term efficacy and safety data after FMT has emerged in the last decade, long remains scarce. We aimed to collect comprehensive long-term follow up on a cohort adult patients who underwent CDI at 3 referral centers. Methods: Patients had between August 2011 October 2017 The Miriam Hospital (TMH), Brigham Woman’s (BWH) Indiana University (IU)...
Introduction: Fecal microbiota transplantation (FMT) has emerged as a definitive treatment option for recurrent Clostridium difficile infection (CDI). Post-infection Irritable Bowel Syndrome (IBS) is common complication after infectious gastroenteritis and frequently observed CDI. We aimed to examine the prevalence of IBS symptoms FMT CDI in patients with without prior diagnosis. Methods: Patients who had between August 2011 October 2017 at The Miriam Hospital (TMH) Brigham Woman’s (BWH)...
INTRODUCTION: Wireless small bowel video capsule endoscopy (VCE) is used to evaluate intestinal bleeding after upper and colonoscopy fail identify a source of bleeding. The majority patients swallow the but endoscopic placement in duodenum an option. Limited data suggests higher rate gastric retention inpatients due variety reasons, resulting incomplete exam. Hypothetically, should increase likelihood complete evaluation there little comparing two approaches. We aimed compare completion...
INTRODUCTION: Enteritis and colitis have wide differential diagnoses including inflammatory bowel disease, infections, ischemia. We present an unusual case of 19-year-old male who presented to the intensive care unit with disseminated adenovirus required a prolonged hospital course went on develop ongoing symptoms non-bloody high output diarrhea. A colonoscopy was performed demonstrated significant right sided colonic disease ulcerations in patchy distribution as well small inflammation...