A5071240327- Fetal and Pediatric Neurological Disorders
- Renal cell carcinoma treatment
- Genetic and Kidney Cyst Diseases
- MRI in cancer diagnosis
- Radiomics and Machine Learning in Medical Imaging
- Renal and related cancers
- Advanced MRI Techniques and Applications
University Hospitals of Cleveland
2024
Case Western Reserve University
2024
Background MR fingerprinting (MRF) provides rapid and simultaneous quantification of multiple tissue parameters in a single scan. Purpose To evaluate kidney MRF technique at 3.0 T phantoms, healthy volunteers, patients. Materials Methods A 15-second acquisition was designed with 12 segments, range low flip angles (5°-12°), magnetization preparation schema (T1, T2, fat suppression), an undersampled spiral trajectory. This first validated vitro using standardized T1 T2 phantoms. Kidney maps...
Motivation: There are no clinically available therapies for ARPKD. Goal(s): We evaluated the ability of T1 and T2 from MR Fingerprinting (MRF) to assess kidney cystic burden Arterial Spin Labeling (ASL) perfusion detect stage ARPKD disease. Approach: 12 patients 10 healthy adult volunteers were scanned on a Siemens 3T with MRF ASL MRI methods generate cortical maps. Results: Significant increases in T2, reduced observed between (p<0.001) early mild-to-moderate CKD based eGFR...
In this study, we applied kidney MR Fingerprinting in characterization of renal cell carcinoma (RCC) and correlated the quantitative T1 T2 values with tumor grade. Our results show significantly lower between high-grade/unclassified RCC group chromophobe/low-grade (55±19 vs. 90±24 msec; P<0.05), while no significant difference was noticed (P>0.05). More importantly, MRF measurements provide complementary information grades a sensitivity 89% specificity 98%...