A5037075876- Advanced Glycation End Products research
- Alcohol Consumption and Health Effects
- Nitric Oxide and Endothelin Effects
- DNA and Nucleic Acid Chemistry
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Advanced biosensing and bioanalysis techniques
- Diabetes and associated disorders
- Monoclonal and Polyclonal Antibodies Research
- Carcinogens and Genotoxicity Assessment
- Diet, Metabolism, and Disease
- Natural Antidiabetic Agents Studies
- Protein Interaction Studies and Fluorescence Analysis
- Blood properties and coagulation
- Eicosanoids and Hypertension Pharmacology
- Adipose Tissue and Metabolism
- Systemic Lupus Erythematosus Research
- Biochemical effects in animals
- Protein purification and stability
- Effects and risks of endocrine disrupting chemicals
- Immunotoxicology and immune responses
- Salivary Gland Disorders and Functions
- T-cell and B-cell Immunology
- Vitamin C and Antioxidants Research
- PARP inhibition in cancer therapy
- Nanoplatforms for cancer theranostics
Aligarh Muslim University
2015-2025
Jawaharlal Nehru Medical College Hospital
2014-2025
Sardar Bahadur Khan Women's University
2023-2024
University of Toledo
2023
International Islamic University, Islamabad
2022
Sarojini Naidu Medical College
2005-2020
Tufts University
2019
Jean Mayer Human Nutrition Research Center on Aging
2019
University of Miami
2019
Chase Farm Hospital
1995
Advanced glycation end-products (AGEs) are known to be mutagenic, diabetogenic and vascular disease risk factors. Methylglyoxal (MG) is a dicarbonyl species that reacts with biological macromolecule (proteins, DNA lipids) give AGEs. Nonenzymatic of MG lysine (Lys) in the presence copper (Cu(2+)) reported generate reactive oxygen (ROS) capable causing damage. We show modification MG-Lys-Cu(2+) system results generation strand breaks, base modification, hyperchromicity increased fluorescence...
Background The oxidation of proteins by endogenously generated free radicals causes structural modifications in the molecules that lead to generation neo-antigenic epitopes have implications various autoimmune disorders, including rheumatoid arthritis (RA). Collagen induced (CIA) rodents (rats and mice) is an accepted experimental model for RA. Methodology/Principal Findings Hydroxyl were Fenton reaction. type II (CII) was modified •OH radical (CII-OH) analysed ultraviolet-visible (UV-VIS),...
Abstract: Ovarian cancer (OC) ranks as the fifth leading cause of cancer-related deaths in United States, posing a significant threat to female health. Late-stage diagnoses, driven by elusive symptoms often masquerading gastrointestinal issues, contribute concerning 70% cases being identified advanced stages. While early-stage OC brags 90% cure rate, progression involving pelvic organs or extending beyond peritoneal cavity drastically diminishes it. Overcoming chemoresistance and metastasis...
Apoptosis, or programmed cell death, is the result of signaling pathways being activated when cells experience irreversible alterations due to internal external stress. To stop cancer from developing, this procedure crucial for getting rid potentially dangerous that have accumulated genetic damage. Nevertheless, a lot create defenses against which aids in growth tumors and treatment resistance. Certain intracellular proteins play key role blocking apoptosis by interfering with specific...
The role of aberrant protein modifications in cancer and its diagnosis have emerged as a promising research field. Nonenzymatic glyco-oxidation proteins under oxidative stress has been associated with carcinogenesis through advanced glycation end products (AGE)–receptors for (RAGE) axis. Modified that are immunogenic stimulate cellular humoral immune responses being studied to develop early detection markers cancer. This study probed the structural alternations; leading formation adducts...
4‐Aminobiphenyl (4‐ABP), an aromatic amine is a major environmental carcinogen found mainly in cigarette smoke. It has been vastly implicated mutagenesis and cancer development. In this study, commercially available human placental DNA was exposed to 4‐ABP (1.3 mM) presence of sodium nitroprusside (SNP; 8 at 37°C for 3 h. The + SNP‐mediated structural changes were studied by ultraviolet, circular dichroism fluorescence spectroscopy, thermal melting profile, agarose gel electrophoresis,...
Background The interaction of environmental chemicals and their metabolites with biological macromolecules can result in cytotoxic genotoxic effects. 4-Aminobiphenyl (4-ABP) several other related arylamines have been shown to be causally involved the induction human urinary bladder cancers. carcinogenic effects 4-ABP are exhibited only when it is metabolically converted a reactive electrophile, aryl nitrenium ions, which subsequently binds DNA induce lesions. Although studies reported...
Non-enzymatic glycation of DNA both in vivo and vitro results generation free radicals, known as glycoxidation. Glycoxidation leads to structural perturbation resulting neo-antigenic epitopes having implication autoimmune disorders like diabetes mellitus. In this study human placental was glycated with methylglyoxal (MG) lysine (Lys) the presence Cu2+ its auto-antibody binding probed Type 1 patients.Glycation carried out by incubating MG, Lys for 24 h at 37 °C. Carboxyethyl deoxyguanosine...