A5043172989- Cardiomyopathy and Myosin Studies
- Muscle Physiology and Disorders
- Asthma and respiratory diseases
- Cardiovascular Effects of Exercise
- Clay minerals and soil interactions
- Recycling and utilization of industrial and municipal waste in materials production
- Energy Load and Power Forecasting
- Occupational and environmental lung diseases
- Electric Power System Optimization
- Adrenal Hormones and Disorders
- Building materials and conservation
- Aerogels and thermal insulation
- Stress Responses and Cortisol
- Statistical Methods and Bayesian Inference
- Thermal and Kinetic Analysis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Hormonal Regulation and Hypertension
- Glass properties and applications
- Cardiovascular Function and Risk Factors
- Immune Response and Inflammation
- Neonatal Respiratory Health Research
- Radioactive element chemistry and processing
- Bauxite Residue and Utilization
- Receptor Mechanisms and Signaling
- Iron oxide chemistry and applications
University of Kragujevac
2019-2024
The University of Melbourne
2017-2019
Institute of Metallurgy
1989
Institute for Technology of Nuclear and other Mineral Raw Materials
1989
Institute of Metals and Technology
1989
Transforming growth factor-beta (TGF-β) is a major mediator of fibrotic diseases, including idiopathic pulmonary fibrosis (IPF). However, therapeutic global inhibition TGF-β limited by unwanted immunosuppression and mitral valve defects. We performed an extensive literature search to uncover little-known connection between signalling casein kinase (CK) activity. have examined the abundance CK1 delta epsilon (CK1δ/ε) in lung tissue from IPF patients non-diseased controls, investigated whether...
Cortisol, a physiologic glucocorticoid (GC), is essential for growth and differentiation of the airway epithelium. Epithelial function influences inflammation in chronic respiratory diseases. Synthetic GCs, including inhaled corticosteroids, exert anti-inflammatory effects epithelium by transactivation genes inhibition proinflammatory cytokine release. We examined effect cortisol on actions synthetic GCs epithelium, demonstrating that acts like partial agonist at GC receptor (GR), limiting...
Impaired therapeutic responses to anti-inflammatory glucocorticoids (GC) in chronic respiratory diseases are partly attributable interleukins and transforming growth factor β1 (TGF-β1). However, previous efforts prevent induction of GC insensitivity by targeting established canonical non-canonical TGF-β1 pathways have been unsuccessful. Here we elucidate a signaling pathway modulating activity that involves LIM domain kinase 2-mediated phosphorylation cofilin1. Severe, steroid-resistant...
Hypertrophic and Dilated Cardiomyopathies are caused by inherited mutations in sarcomeric proteins: Myosin (M), Troponin (Tn), Tropomyosin (Tm) Binding Protein-C (MyBP-C). A quantitative understanding of how change protein behaviour, hence cardiac muscle contraction, adaptations to these changes result disease, could accelerate the design novel personalized treatments therapeutics. Newly developed multiscale computational tools, tightly interlaced with multiple experiments, can enhance...
The SILICOFCM platform is an in-silico cloud computing which utilizes advanced computational workflows for drug development and optimized clinical therapy in the domain of hypertrophic cardiomyopathy (HCM). current study presents SILICOFCM's virtual population model (VPM) can be used to generate high-quality data using both multivariate machine learning methods along with geometries trials. proposed VPM workflow includes quality management functionalities outlier detection similarity are...
Continuous degeneration of muscle tissue, inflammatory processes and fibrosis characterized by a loss mass, formation micro-scars, adipose tissue in the muscles eventual punctures are often signs muscular dystrophies (dystrophinopathies). These neuromuscular diseases result from genetic mutations structural protein called dystrophin. The absence functional dystrophin leads to most common severe form dystrophy, Duchenne dystrophy (DMD). Typically, within one bundle there so-called fast slow...