A5084978772- Bone Tissue Engineering Materials
- Cardiovascular Function and Risk Factors
- Orthopaedic implants and arthroplasty
- Dental materials and restorations
- Advanced X-ray and CT Imaging
- Scientific Computing and Data Management
- Cardiac Ischemia and Reperfusion
- Electrospun Nanofibers in Biomedical Applications
- Cardiac electrophysiology and arrhythmias
- 3D Printing in Biomedical Research
- Tissue Engineering and Regenerative Medicine
- Additive Manufacturing Materials and Processes
- Mathematical Biology Tumor Growth
- Energy Load and Power Forecasting
- Pluripotent Stem Cells Research
- IoT and Edge/Fog Computing
- Dental Implant Techniques and Outcomes
- Zebrafish Biomedical Research Applications
- Distributed and Parallel Computing Systems
- Balance, Gait, and Falls Prevention
- Bone fractures and treatments
- Context-Aware Activity Recognition Systems
- Cardiomyopathy and Myosin Studies
- Gas Sensing Nanomaterials and Sensors
- Cardiac Imaging and Diagnostics
University of Ioannina
2016-2024
Montanuniversität Leoben
2023
Newcastle University
2023
University of Kragujevac
2021
A combined computational and experimental study of 3D-printed scaffolds made from hybrid nanocomposite materials for potential applications in bone tissue engineering is presented. Polycaprolactone (PCL) polylactic acid (PLA), enhanced with chitosan (CS) multiwalled carbon nanotubes (MWCNTs), were investigated respect their mechanical characteristics responses fluidic environments. novel scaffold geometry was designed, considering the requirements cellular proliferation properties. Specimens...
Through the recent years, tissue engineering has been proven as a solid substitute of autografts in stimulation bone regeneration, through development three dimensional (3D) porous matrices, commonly known scaffolds. In this work, we analysed two scaffold structures with 500μm pore size, by performing computational fluid dynamics simulations, to compare permeability, Wall Shear Stress (WSS), velocity and pressure distributions. Taking into account those parameters geometry named "PCL-50" was...
Experimental studies indicate improved ventricular function after treatment with growth hormone (GH) post-myocardial infarction, but its effect on arrhythmogenesis is unknown. Here, we assessed the medium-term electrophysiologic remodeling intra-myocardial GH administration in (n = 33) rats. was released from an alginate scaffold, injected around ischemic myocardium coronary ligation. Two weeks thereafter, tachyarrhythmias were induced by programmed electrical stimulation. Monophasic action...
Embryonic Stem (ES) or induced Pluripotent (iPS) cells are important sources for cardiomyocyte generation, targeted regenerative therapies. Several in vitro protocols currently utilized their differentiation, but the value of cell-based approaches remains unclear. Here, we characterized a cardiovascular progenitor population derived during ES after selection based on VE-cadherin promoter (Pvec) activity. ESCs were genetically modified with an episomal vector, allowing expression puromycin...
In accordance with the latest aspirations in field of bioengineering, there is a need to create web accessible, but powerful cloud computational platform that combines datasets and multiscale models related bone modeling, cancer, cardiovascular diseases tissue engineering. The SGABU may become information system for research education can integrate data, extract information, facilitate knowledge exchange goal creating developing appropriate computing pipelines provide accurate comprehensive...
Abstract Introduction: Open reduction internal fixation (ORIF) and external are traditional surgical techniques for treating type VI Schatzker tibial plateau fractures. A newly developed technique integrates the intramedullary nail with condylar bolts. This finite element study investigated mechanical response of three fixing We compared nail-bolt (IMNB) single lateral locking plate (SLLP) dual plating (DP) techniques.
Materials&Methods: 4th generation Sawbone model a left tibia...
This study aims to comprehensively evaluate the mechanical performance of bone scaffolds, focusing on a compression test displacement rate 0.5mm/s and 2mm/min. The research employs Yeoh 3rd order model for hyperelastic PLA scaffolds simulate tests, which are validated using experimental results. More specifically, stress- strain curves derived from in-silico analysis exhibit strong agreement with results, highlighting reliability computational approach. Two distinct scaffold geometries were...
Multiple studies for balance rehabilitation interventions have been accomplished aiming to demonstrate that sensory and cognitive functionality are crucial postural control improvement of the quality patient's daily life. However, none existing is filling lack expert physiotherapists availability. A pilot randomized study was conducted assess acceptability HOLOBalance telerehabilitation system. an interactive AR system which encompasses multi-sensory training program enhance coaching, older...
Background Cardiac repair strategies are being evaluated for myocardial infarctions, but the safety issues regarding their arrhythmogenic potential remain unresolved. By utilizing in-vivo rat model, we have examined medium-term electrophysiologic effects of a biomaterial scaffold that has been cellularized with spheroids human adipose tissue, derived from mesenchymal stem cells and umbilical vein endothelial cells. Methods Mesenchymal cells, which exhibit adequate differentiation capacity,...
Left ventricular (LV) segmentation is an important process which can provide quantitative clinical measurements such as volume, wall thickness and ejection fraction. The development of automatic LV procedure a challenging complicated task mainly due to the variation heart shape from patient patient, especially for those with pathological physiological changes. In this study, we focus on implementation, evaluation comparison three different Deep Learning architectures U-Net family: custom 2-D...
In accordance with the latest aspirations in field of bioengineering, there is a need to create web accessible, but powerful cloud computational platform that combines datasets and multiscale models related bone modeling, cancer, cardiovascular diseases tissue engineering. The SGABU may become information system for research education can integrate data, extract information, facilitate knowledge exchange goal creating developing appropriate computing pipelines provide accurate comprehensive...
During the past years, tissue engineering has been qualified as a solid surrogate of autografts in stimulation bone regeneration, through development three dimensional (3D) porous matrices, commonly known scaffolds. Polycaprolactone-based scaffolds have attracted worldwide attention promising biodegradable implants engineering. Finite Element Analysis is used to evaluate mechanical behaviour and simulate processes inside scaffold. In this work, we analysed two regular polycaprolactone...
The SILICOFCM platform is an in-silico cloud computing which utilizes advanced computational workflows for drug development and optimized clinical therapy in the domain of hypertrophic cardiomyopathy (HCM). current study presents SILICOFCM's virtual population model (VPM) can be used to generate high-quality data using both multivariate machine learning methods along with geometries trials. proposed VPM workflow includes quality management functionalities outlier detection similarity are...