A5039218068- Malaria Research and Control
- Mosquito-borne diseases and control
- Global Maternal and Child Health
- Bird parasitology and diseases
- Vector-borne infectious diseases
- Healthcare Systems and Reforms
- Helminth infection and control
- Trypanosoma species research and implications
- CRISPR and Genetic Engineering
- Global Health Care Issues
- Mobile Health and mHealth Applications
- Aquaculture disease management and microbiota
- HIV/AIDS Impact and Responses
- Complement system in diseases
- SARS-CoV-2 and COVID-19 Research
- HIV/AIDS Research and Interventions
- Parasites and Host Interactions
- Microbial infections and disease research
- Child Nutrition and Water Access
- Reproductive Health and Contraception
- SARS-CoV-2 detection and testing
- Adolescent Sexual and Reproductive Health
- Insect symbiosis and bacterial influences
- COVID-19 diagnosis using AI
- ICT in Developing Communities
Sanru
2015-2024
Primary Health Care
2024
Njala University
2023
Global Fund to Fight AIDS, Tuberculosis and Malaria
2020-2021
University of Kinshasa
2021
CRISPR-based diagnostics are a new class of highly sensitive and specific assays with multiple applications in infectious disease diagnosis. SHERLOCK, or Specific High-Sensitivity Enzymatic Reporter UnLOCKing, is one such diagnostic that combines recombinase polymerase pre-amplification, CRISPR-RNA base-pairing, LwCas13a activity for nucleic acid detection.
Abstract Background Though Plasmodium vivax is the second most common malaria species to infect humans, it has not traditionally been considered a major human health concern in central Africa given high prevalence of Duffy-negative phenotype that believed prevent infection. Increasing reports asymptomatic and symptomatic infections individuals throughout raise possibility P. evolving evade host resistance, but there are few parasite samples with genomic data available from this part world....
Malaria is preventable and treatable when recommended interventions are properly implemented. Thus, diagnosis treatment focus on symptomatic individuals while asymptomatic Plasmodium infection (PI) plays a role in the sustainability of transmission may also have an impact morbidity disease terms anaemia, nutritional status even cognitive development children. The objective this study was to assess PI prevalence its relationship with known factors vulnerable but stratum population. A simple...
The majority of Plasmodium falciparum malaria diagnoses in Africa are made using rapid diagnostic tests (RDTs) that detect histidine-rich protein 2. Increasing reports false-negative RDT results due to parasites with deletions the pfhrp2 and/or pfhrp3 genes (pfhrp2/3) raise concern about existing strategies. We previously identified pfhrp2-negative among asymptomatic children Democratic Republic Congo (DRC), but their impact on diagnosis symptomatic is unknown. performed a cross-sectional...
Abstract Background While Plasmodium falciparum and vivax cause the majority of malaria cases deaths, infection by malariae other species also causes morbidity mortality. Current understanding these infections is limited in part existing point-of-care diagnostics that fail to differentiate them have poor sensitivity for low-density infections. Accurate diagnosis currently requires molecular assays performed well-resourced laboratories. This report describes development a P. diagnostic assay...
Abstract Plasmodium ovale curtisi ( Poc) and wallikeri Pow ) are relapsing malaria parasites endemic to Africa Asia that were previously thought represent a single species. Amid increasing detection of in sub-Saharan Africa, we performed population genomic study both species across the continent. We conducted whole-genome sequencing 25 isolates from Central East analyzed them alongside 20 published African genomes. Isolates predominantly monoclonal (43/45), with their genetic similarity...
The parasite species Plasmodium ovalecurtisi (P. ovalecurtisi) and ovalewallikeri ovalewallikeri), formerly known as ovale, are endemic across multiple African countries. These thought to differ in clinical symptomatology latency, but only a small number of existing diagnostic assays can detect distinguish them. In this study, we sought develop new for the detection differentiation P. by leveraging recently published whole-genome sequences both species.
Abstract Plasmodium ovale curtisi ( Poc) and wallikeri Pow ) are relapsing malaria parasites endemic to Africa Asia that were previously thought represent a single species. Amid increasing detection of in sub-Saharan Africa, we present population genomic study both species across the continent. We conducted whole-genome sequencing 25 isolates from Central East analyzed them alongside 20 published African genomes. Isolates predominantly monoclonal (43/45), with their genetic similarity...
In early 2016, we implemented a community-based maternal, newborn, and child health (MNCH) surveillance using mobile phones to collect, analyze, use data by village volunteers (VHV) in Kenge Health Zone (KHZ), the Democratic Republic of Congo (DRC). The objective this study was determine perceptions households, attitudes community volunteers, opinions nurses center administrative authorities towards for MNCH rural KHZ DRC.We used mixed methods combining phenomenological descriptive...
Abstract Background P. ovale spp. infections are endemic across multiple African countries and caused by two distinct non-recombining species, curtisi ( Poc ) wallikeri Pow ). These species thought to differ in clinical symptomatology latency, but existing diagnostic assays have limited ability detect distinguish them. In this study, we developed a new duplex assay for the detection differentiation of that can be used improve our understanding these parasites. Methods Repetitive sequence...
The burden of maternal and child mortality is high in the Democratic Republic Congo (DRC). While health workers (HWs) with adequate knowledge practice (MCH) are crucial to reduce this burden, skill level HWs charge MCH DRC currently insufficient. This study aimed assess towards Kasai Maniema, two provinces very ratios under-5 rates.
<title>Abstract</title> Background The establishment of Community Health Care Sites (CHCS) is an opportunity for the use SARS-COV-2 antigenic rapid diagnostic test (Ag RDTs) at community level to contribute control circulation SARS-CoV-2. objective this study was evaluate contribution CHCS detection Covid-19 cases in Democratic Republic Congo. Methods descriptive cross-sectional using two approaches: a quantitative approach and qualitative 112 CHCS. Data on COVID-19 screening during 4 months...
Background : Antiretroviral combination therapy is known as option B+ for the prevention of mother-to-child transmission (PMTCT) human immunodeficiency virus (HIV).Administration a task delegated to nurses and midwives who are involved in pre-and post-natal consultations health facilities that have integrated this intervention.This study was carried out understand perceptions providers Lubumbashi, Democratic Republic Congo regarding tasks them, identify challenges they face implementation...
ABSTRACT CRISPR-based diagnostics are a new class of highly sensitive and specific assays with multiple applications in infectious disease diagnosis. SHERLOCK, or Specific High-Sensitivity Enzymatic Reporter UnLOCKing, is one such diagnostic that combines recombinase polymerase pre-amplification, CRISPR-RNA base-pairing, LwCas13a activity for nucleic acid detection. We developed SHERLOCK malaria capable detecting all Plasmodium species known to cause humans species-specific detection P....
Abstract Background: The Democratic Republic of the Congo (DRC) is classified among 5 countries with highest global maternal mortality ratio (MMR) and under-five rate (U5MR) in world. Kasai one 14 provinces DRC, which have a high U5MR MMR. Despite this overriding concern, almost no studies been conducted to assess et child situation province. aim study was access, availability, quality health services Province DRC. Methods : A cross-sectional survey 49 Health Facilities (HFs) integrating...
is found worldwide and causes chronic parasitism in its human hosts. We developed a
<title>Abstract</title> Background The use of contraceptive methods remains an imperative for birth spacing. Bomoyi project SANRU Asbl, has invested during the last 3 years to improve its among adolescents. objective this study was assess level youth in Alunguli health zone. Methods conducted Health Zone, one 18 zones Maniema Province Democratic Republic Congo. It a descriptive cross-sectional with analytical purpose from June 1 December 31, 2021. A stratified sample 345 records randomly...
ABSTRACT Background The majority of Plasmodium falciparum malaria diagnoses in Africa are made using rapid diagnostic tests (RDTs) that detect histidine-rich protein 2. Increasing reports false-negative RDT results due to parasites with deletions the pfhrp2 and/or pfhrp3 genes ( pfhrp2/3 ) raise concern about existing strategies. We previously identified pfhrp2- negative among asymptomatic children Democratic Republic Congo (DRC), but their impact on diagnosis symptomatic is unknown. Methods...
Abstract Plasmodium vivax malaria has not traditionally been a major concern in central Africa given the high prevalence of human Duffy-negative phenotype that is believed to prevent infection. Increasing reports asymptomatic and symptomatic infections individuals throughout raise possibility P. evolving evade host resistance, but there are few parasite samples with genomic data available from this part world. In study, we perform whole genome sequencing new isolate Democratic Republic Congo...
Background: The Democratic Republic of the Congo (DRC) is among five countries with highest global maternal mortality ratio (MMR) and under-five rate (U5MR) worldwide. One 14 provinces in DRC that have high U5MR MMR Kasai. Despite this overriding concern, assessment child situation province remains poorly reported.