The increasing threat of antibiotic resistance has created an urgent need for new antibacterial agents, particularly plant-based natural compounds and their derivatives. Thymol, a monoterpenoid phenolic compound derived from Monarda citriodora , is known its aromatic therapeutic properties, including activity. This study focuses on synthesizing dihydropyrimidinone dihydropyridine derivatives thymol exploring properties. synthesized were tested in vitro potential against pathogenic...

To determine sexual dysfunctions and urinary symptoms in male ankylosing spondylitis (AS) patients their association with various disease patient factors.In this prospective case control study conducted at a tertiary care teaching institution, 100 males AS were compared to controls using International Index of Erectile Function-15 (IIEF), Prostate Symptom Score (IPSS), Hospital Anxiety Depression Scale (HADS) global question for overall relationship partners. Bath Functional (BASFI), visual...

To evaluate the occurrence of dental injuries in children, level knowledge participants about preventive measures, and management trauma during sports, New Delhi.A cross-sectional study was carried out among 450 children aged 6 to 16 years. A structured interviewer-guided questionnaire used determine prevalence oral sustained sport activities, use mouthguard as well athlete's awareness regarding mouthguard. The respondents consisted 313 males (69.6%) 137 females (30.4%) with a mean age 12.6...

To study the distribution of various rheumatological diseases in rural and urban areas Lucknow, India.A using adapted a Community Oriented Program for Control Rheumatic Diseases scheme was carried out cluster (n = 5118) 5053) communities through door-to-door survey. Trained community volunteers completed questionnaires. Patients with musculoskeletal pain (MSK pain) were clinically evaluated by physician. X-ray examinations blood investigations also done. Diagnosis made according to...

Takayasu arteritis is an inflammatory disease of unknown aetiology affecting large vessels. Medium vessel involvement also well documented; however, neuropathy as a presenting manifestation rare. In this case report, young woman in her 20s presented with 8-month history intermittent claudication the right upper limb progressing to rest pain allodynia C5–C8 distribution and painless axillary mass. On examination, she had absent pulses radial, brachial subclavian artery audible bruit abdominal...

Abstract Objectives To study the prevalence of rheumatic musculoskeletal symptoms in rural and urban areas Lucknow. Method The survey was carried out a cluster ( n = 5118) 5053) communities Lucknow through door‐to‐door survey. Demographic data were collected subjects with pain MSK pain) identified. A Hindi adapted version Community Oriented Program for Control Rheumatic Diseases questionnaire used. Trained community volunteers completed questionnaire. Results Present past most common...

Background and aims:The aim of the study was to evaluate compare surface microhardness morphology permanent tooth enamel after Er,Cr:YSGG laser irradiation Fluoride application.Materials methods: One hundred twenty premolars extracted for orthodontic purpose were used in randomly divided into 6 groups.Group A not subjected any treatment.Group B irradiation.Group C followed by application 2% NaF gel 4 minutes.Group D 1.23% APF E pretreatment technique F irradiation.All test groups testing...

Objectives: To assess causes of vaccine hesitancy to COVID-19 vaccines in patients with autoimmune rheumatic diseases (AIRD). Methods: Study design: We conducted a cross-sectional observational survey-based study attending Rheumatology OPD regarding the reason for hesitancy, counselled by treating rheumatologists and responses willingness recorded after counselling. Convenience sampling was done including all adults (>18 years) AIRD rheumatology OPD. Those vaccinated, recently infected...

Background: Ankylosing spondylitis (AS) involves pathological new bone formation in the cortical zone of vertebrae and excessive loss trabecular center vertebral body causing osteoporosis (OP). OP expressed as reduced mineral density (BMD) is a common complication AS. Tumor necrosis factor-α (TNF-α) causes induction Dickkopf-1 sclerostin, which downregulates by inhibiting wingless proteins morphogenic proteins. Materials Methods: Fifty AS patients were compared with an equal number age-...

Objectives: The aim of this study was to evaluate the association and prevalence hypertension in patients with Fibromyalgia Syndrome (FMS). Methods: 100 consecutive FMS were screened for it found 61 patients. diagnosed according 1990 American College Rheumatology criteria. blood pressure measured by using mercury splygnomanometer WHO protocol. Symptoms FIQR. Counts 18 tender points performed thumb palpation levels hormonal profiles (Cortisol, melatonin serotonin) recorded each patient....

A cohort study was carried out for a year to evaluate the presence of G-to-A transition in 5'-untranslated region ankylosis human (ANKH) gene Indian Khatri patients (closely resembling Europeans primary knee osteoarthritis (OA), residing Lucknow, India.In total participants, 25 were OA (cases) Lucknow and 101 random blood donors' samples (controls) collected from bank. All studied abovementioned mutation using real-time polymerase chain reaction (RT-PCR). GG genotype present 72.3% controls...

A 30-year-old female with hypothyroidism presented a 6-month history of bilaterally symmetrical small and large joint inflammatory arthritis involving the elbow, wrist, metacarpophalangeal (MCP), proximal interphalangeal (PIP) distal (DIP). After 4 months she started noticing papulonodular lesions over dorsal palmar surfaces both hands; similar on elbows conchae ears followed (Fig. 1). The hand radiograph suggested non-erosive arthritis. Biopsy lesion revealed well-circumscribed focus...

A 31-year-old female with hypothyroidism and multicentric reticulohistiocytosis (MRH) had lesions on hands, ears elbows [1]. She was started MTX HCQ 8 mg methylprednisolone, to which she an incomplete response (her stabilized but her arthritis persisted). TNF-inhibitors tocilizumab were not financially feasible for her. refused CYC due fertility concerns. It decided give a trial of tofacitinib. Her symptoms improved little few months, the improvement short-lived. skin getting worse, new...

Ankylosing spondylitis is a common inflammatory rheumatic disease that affects the axial skeleton, causing characteristic back pain, which can lead to structural and functional impairments decrease in quality of life. New imaging techniques therapies have substantially changed management this past decade. Whether inhibition radiographic progression damage be reached with available drugs as yet unclear. Furthermore, treatment non-steroidal anti-inflammatory agents physiotherapy remains an...

<h3>Background</h3> Juvenile Idiopathic Arthritis (JIA) is an umbrella term for chronic arthritis with onset before 16 years of age. According to ILAR classification criteria it subdivided in 6 category. Growth failure a well observed phenomenon JIA and more so Systemic polyarticular variants. Except from western literature, Asian countries Enthesitis Related (ERA) prevalent. In our study, we have studied the growth development patients variant. <h3>Objectives</h3> To assess prevalence...