Oxygen-containing heterocycles are largely distributed in natural and synthetic compounds. Coumarins among the most famous which possess one oxygen atom their rings. classified as multifunctional scaffold used anti-oxidant reagents, anti-inflammatory, anti-microbial, anti-fungal, anti-HIV active, analgesic, anti-histaminic, insecticides, dyes, herbicides, sensitizers, perfumes, cosmetics food additives. Due to diverse applications industrial pharmaceutical fields, many chemists have given...

Schiff bases represent an essential class in organic chemistry with antitumor, antiviral, antifungal, and antibacterial activities. The synthesis of requires the presence base as a catalyst such piperidine. Base-free compounds using heterogeneous has recently attracted more interest due to facile procedure, high yield, reusability used catalyst. Herein, we present comparative study synthesize new containing indole moieties piperidine Au@TiO

We present here the FT-IR, DFT computation, XRD, optical, and photophysical characterization of a heterocyclic compound with thienopyrimidine pyran moieties. TD-DFT/DMOl3 TD-DFT/CASTEP computations were used to study geometry isolated dimer molecules their optical behavior. The indirect (3.93 eV) direct (3.29 energy bandgaps, HOMO-LUMO gap (3.02 eV), wavelength maximum absorption (353 nm) determined in gas phase M062X/6-31+G (d, p). A thin film studied molecule was using UV-Vis spectroscopy....

Four novel lanthanide La (III), Ce Nd and Dy (III) complexes with (Z)‐4‐(benzo[d]thiazol‐2‐ylamino)‐3‐((benzo[d]thiazol‐2‐ylimino)methyl)‐2H‐chromen‐2‐one (L) were prepared characterized. The compounds' structural compositions elucidated by the application of analytical spectroscopic methodologies. From physical chemical measurements, general formula for [LnL Cl 3 ]2H 2 O (C1‐C4) was proposed, which proven theoretical measurements. Using cisplatin, gentamicin, ampicillin, ascorbic acid as...

5‐Amino‐2‐( p ‐tolylamino)‐4‐phenylthieno[2,3‐ d ]pyrimidine‐6‐carbonitrile 9 , which was synthesized by an innovative method, used as a versatile precursor for synthesizing pyrimido‐thienopyrimidine, triazolopyrimidothienopyrimidine, and pyrimidothienotriazine compounds. Thus, reaction of aminothienopyrimidinecarbonitrile with chloroacetylchloride in dioxane afforded the chloroacetylaminocarbonitrile derivative 10 underwent nucleophilic substitution reactions various primary secondary...

Pyrimidine compounds continue to attract great interest in the field of organic synthesis due their various chemical and biological applications observed, especially recent times. As a result, this review covering some periods from 1957 2021 has been prepared discuss structural pathways these as well interactions applications.

This study presents a convenient and eco-friendly method for synthesizing 5-aryl pyrazole-3-one derivatives through the oxidation of 4-arylidinepyrazolidinediones using chromium trioxide nanoparticles in an acidic medium. The reaction was facilitated by sonication acetic acid, yielding desired compounds good to excellent yields. Additionally, N-substituted pyrazolone were synthesized via with various alkylating agents presence ionic liquid [DABCO-EtOH][AcO], achieving remarkable...

Thiazolopyrimidnes are considered one of the most interesting classes in heterocyclic chemistry due to their pharmaceutical importance. Herein, we report synthesis some new compounds containing thiazolopyrimidine starting from compound (1) which was previously prepared literature. The allowed react with different alkylating agents such as chloroacetone, chloroacetyl chloride, and phenacyl bromide afford derivatives (2-4). Compound (5), benzylidene derivative, obtained by reaction (2)...

Heterocyclic compounds with effective solid-state luminescence offer a wide range of uses. It has been observed that combining pyrimidine and indole moieties in single molecule can enhance material behavior dramatically. Here, different heterocyclic have synthesized effectively, their structures validated using NMR, IR, mass spectroscopy. The photoluminescence two substances was investigated powder form solutions varying concentrations. After aggregation, one displayed redshifted spectrum,...

Abstract Incorporating coumarin nuclei into other heterocyclic scaffolds such as thienopyrimidine can significantly increase the photophysical and biological efficiency. Accordingly, we describe in this manuscript synthesis of new derivatives containing combined pyrimidine to maximize application benefit target compounds. All synthesized were thoroughly characterized using spectral analyses FT‐IR, NMR, mass spectroscopy. The properties four compounds solution investigated, where...

Nowadays heterocyclic compounds containing pyrimidine scaffold attract the interest of many organic chemists due to their strong biological activity, so herein we present synthesis new polycyclic starting from 4-chloro-9-phenyl-N-(p-tolyl)pyrimido[5',4':4,5]thieno[3,2-d][1,2,3]triazin-7-amine (1) which allowed react with hydrazine hydrate give hydrazinyl triazine compound (2) subjected some ring closure reactions using various reagents represented in triethyl orthoformate, acetyl acetone,...

A thin film of 7-oxo-thiazolopyrimidine-3,8-dicarbonitrile derivative [7-ThPyDi]TF was prepared using a spin coating technique. The surface morphology and molecular structure are studied various techniques such as XRD, FTIR, scanning electron microscope (SEM). Moreover, the quantum chemical calculations were carried out through time-dependent density functional theory (TD-DFT) to investigate some reactivity descriptors softness electronegativity. Also, Au/[7-ThPyDi]TF/p-Si/Al heterojunction...

Due to the biological activities of pyrimidine and thienopyrimidine as antimicrobial agents, so in present work, a series new heterocyclic compounds containing moiety were synthesized such as, tetrazolo[1",5":1',6']pyrimido [4',5':4,5]thieno[2,3-d]pyrimidine derivatives (8-12b), pyrimido[3",2":1',6']pyrimido[4',5':4,5]thieno[2,3-d]pyrimidine (14,16) pyrimido[5',4':4,5]thieno[2,3-e]pyrimido[1,2-c] [1,2,3]triazine derivative (15) by using...

Heterocyclic compounds play an important role in the field of pharmaceutical chemistry, especially containing hybrid bioactive moieties. So continuation our work, We focused mainly here on design, synthesis, and transformations novel bio-active molecules bearing thieno[2,3-d]pyrimidine moiety which can be used as antibacterial antifungal drugs after some modifications. The starting compound 2-chloromethyl-3H-7-p-tolylamino-4-oxo-9-phenyl-pyrimido[4',5':4,5]thieno[2,3-d]pyrimidine (1) was...

Pyrimidine and thienopyrimidine derivatives play a very important role in organic chemistry because of their wide applications as bioactive compounds with multiple biological activities. However, literature survey revealed that the merger different groups thieno[2,3‐ d ]pyrimidine heterocyclic ring enhances its antibacterial, antifungal anti‐inflammatory This encouraged us to prepare new series test them antimicrobial agents. These have shown remarkable activity toward fungi, bacteria,...