A5017071546- Analytical Methods in Pharmaceuticals
- Antibiotics Pharmacokinetics and Efficacy
- Anesthesia and Sedative Agents
- Renal function and acid-base balance
- Mass Spectrometry Techniques and Applications
- Analytical Chemistry and Chromatography
- Cardiovascular Conditions and Treatments
- Pesticide Residue Analysis and Safety
- Pharmacogenetics and Drug Metabolism
- Analytical chemistry methods development
- Metabolomics and Mass Spectrometry Studies
- Neonatal Respiratory Health Research
- Cardiac Arrhythmias and Treatments
- Mechanical Circulatory Support Devices
- Microfluidic and Capillary Electrophoresis Applications
University of Tartu
2017-2019
St George's, University of London
2019
Traditionally, bioanalytical laboratories do not report actual concentrations for samples with results below the LOQ (BLQ) in pharmacokinetic studies. BLQ values are outside method calibration range established during validation and no data available to support reliability of these values. However, ignoring can contribute bias imprecision model-based analyses. From this perspective, routine use would be advantageous. We like initiate an interdisciplinary debate on important topic by...
Sample preparation for the analysis of clinical samples with mass spectrometer (MS) can be extensive and expensive. Simplifying speeding up process would very beneficial. This paper reports sponge spray-a novel sampling direct MS approach-attempting exactly that. It enables without any sample from dried blood, plasma, urine. The tip a volumetric absorptive microsampling device is used to collect an exact amount that same electrospray directed into spectrometer. We demonstrate here that,...
This research focuses on retention mechanisms in a LC column with C18 stationary phase when novel eluent additives (HFIP, HFTB and TFE as well NFTB perfluoropinacol) are used. The factors between conventional ones like ammonium acetate bicarbonate at different pH values were compared. A simple set of drug-like molecules, widely spread over logP values, containing protonated deprotonated acids bases was selected for this investigation. HFIP, HFTB, PP demonstrated strong influence basic polar...
To describe the pharmacokinetics (PK) and concentration-related effects of dobutamine in critically ill neonates first days life, using nonlinear mixed modelling.
Objectives: The postoperative course of patent ductus arteriosus ligation is often complicated by postligation cardiac syndrome, occurring in 10–45% operated infants. Milrinone might prevent profound hemodynamic instability and improve the recovery function this setting. present study aimed to describe population pharmacokinetics milrinone premature neonates at risk syndrome give dosing recommendations. Design: A prospective single group open-label study. Settings: Two tertiary care neonatal...