A5102965371- Marine Invertebrate Physiology and Ecology
- Photoreceptor and optogenetics research
- Receptor Mechanisms and Signaling
- Advanced Photocatalysis Techniques
- Photosynthetic Processes and Mechanisms
- Retinal Development and Disorders
- Enzyme Structure and Function
- Bacteriophages and microbial interactions
- Invertebrate Taxonomy and Ecology
- Microtubule and mitosis dynamics
- Marine and Coastal Research
- Protein Structure and Dynamics
- Viral gastroenteritis research and epidemiology
- Electrochemical sensors and biosensors
- Glycosylation and Glycoproteins Research
- TiO2 Photocatalysis and Solar Cells
- Iron oxide chemistry and applications
- Nuclear Structure and Function
- Enzyme function and inhibition
- Biochemical Analysis and Sensing Techniques
- bioluminescence and chemiluminescence research
- Light effects on plants
- Advanced oxidation water treatment
- Cancer therapeutics and mechanisms
- Effects and risks of endocrine disrupting chemicals
Jeonbuk National University
2016-2025
Inha University
2017
Chonbuk National University Hospital
2013-2016
Nutrasource
2016
University of Toronto
2013
University of Ulsan
2010-2012
Charité - Universitätsmedizin Berlin
2003-2011
Humboldt-Universität zu Berlin
2003
University of Suwon
1998
A key factor in dendritic cell (DC)-based tumor immunotherapy is the identification of an immunoadjuvant capable inducing DC maturation to enhance cellular immunity. The efficacy a 50S ribosomal protein L7/L12 (rplL) from Mycobacterium tuberculosis Rv0652, as for DC-based immunotherapy, and its capacity was investigated. In this study, we showed that Rv0652 recognized by Toll-like receptor 4 (TLR4) induce maturation, pro-inflammatory cytokine production (TNF-alpha, IL-1beta, IL-6) partially...
The G protein coupled receptor rhodopsin contains a pocket within its seven-transmembrane helix (TM) structure, which bears the inactivating 11-cis-retinal bound by protonated Schiff-base to Lys296 in TM7. Light-induced 11-cis-/all-trans-isomerization leads deprotonated active Meta II intermediate. With decay, bond is hydrolyzed, all-trans-retinal released from pocket, and apoprotein opsin reloaded with new 11-cis-retinal. crystal structure of Ops* conformation provides basis for...
Receptor-ligand interaction: Olfactory receptors (ORs) are G-protein-coupled (GPCRs), which detect signaling molecules such as hormones and odorants. The structure of opsin, the GPCR employed in vision, with a detergent molecule bound deep its orthosteric ligand-binding pocket provides template for OR homology modeling, thus enabling investigation structural basis mechanism odorant-receptor recognition.
Herein we report the influence of a ZrO2 underlayer on PEC (photoelectrochemical) behavior hematite nanorod photoanodes for efficient solar water splitting. Particular attention was given to cathodic shift in onset potential and photocurrent enhancement. Akaganite (β-FeOOH) nanorods were grown ZrO2-coated FTO (fluorine-doped tin oxide) substrates. Sintering at 800 °C transformed akaganite (α-Fe2O3) phase induced Sn diffusion into crystal structure from substrates surface migration, shallow...
Photoisomerization of rhodopsin activates a heterotrimeric G-protein cascade leading to closure cGMP-gated channels and hyperpolarization photoreceptor cells. Massive translocation the visual transducin, Gt, between subcellular compartments contributes long term adaptation Ca2+-triggered assembly centrin-transducin complex in connecting cilium cells may regulate these transducin translocations. Here we demonstrate expression all four known, closely related centrin isoforms mammalian retina....
Extracellular signals prompt G protein-coupled receptors (GPCRs) to adopt an active conformation (R*) and catalyze GDP/GTP exchange in the alpha-subunit of intracellular proteins (Galphabetagamma). Kinetic analysis transducin (G(t)alphabetagamma) activation shows that intermediary R*xG(t)alphabetagamma.GDP complex is formed precedes GDP release formation nucleotide-free R*xG protein complex. Based on this reaction sequence, we explore dynamic interface between during these complexes. We...
TNT-2D material prepared <italic>via</italic> molten salt NRs for efficient Sr<sup>2+</sup> adsorption.
We demonstrate the charge transport characteristics of MoS2-based vertical heterojunction devices through formation interfacial strain. Atomically thin MoS2 bilayers were directly synthesized on a p-type Si substrate by using chemical vapor deposition to introduce an tensile strain in diode structure, which was confirmed Raman, X-ray and ultraviolet photoelectron spectroscopy techniques. The electrical optoelectronic properties with as-grown (A-MoS2) p-Si compared those transferred...
Dysregulation of anaplastic lymphoma kinase (ALK) has been detected in nonsmall cell lung cancer (NSCLC) the form EML4-ALK fusion. Secondary mutations opposing activity first-generation ALK inhibitor crizotinib came into existence, requiring mutation-targeting drug discovery for powerful second-line treatment. In this study, we report 4-phenoxyquinoline-based inhibitors that overcome resistance to L1196M, discovered by fragment-growing strategy. The protonation 4-aminoquinoline core could...