A5087702265- Dialysis and Renal Disease Management
- Renal Transplantation Outcomes and Treatments
- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
- Chronic Kidney Disease and Diabetes
- Health Systems, Economic Evaluations, Quality of Life
- Poisoning and overdose treatments
- Pharmacological Effects and Toxicity Studies
- Drug-Induced Hepatotoxicity and Protection
- Organ Donation and Transplantation
- Chronic Disease Management Strategies
- HIV/AIDS drug development and treatment
- COVID-19 Impact on Reproduction
- Renal Diseases and Glomerulopathies
- Renal and Vascular Pathologies
- Acute Kidney Injury Research
- Blood Pressure and Hypertension Studies
- Systemic Lupus Erythematosus Research
- Global Cancer Incidence and Screening
- Pharmacogenetics and Drug Metabolism
- Neurological Complications and Syndromes
- Central Venous Catheters and Hemodialysis
- Muscle and Compartmental Disorders
- Organ Transplantation Techniques and Outcomes
- Autopsy Techniques and Outcomes
Hospital Selayang
2013-2024
Ministry of Health
2019-2024
Sunway University
2024
University of Hong Kong
2018-2022
Chinese University of Hong Kong
2022
Providence Health Care
2016
University of British Columbia
2016
St. Paul's Hospital
2016
Centre for Health Evaluation and Outcome Sciences
2016
BC Cancer Agency
2016
The aim of the present study was to evaluate efficacy mycophenolate mofetil in induction therapy proliferative lupus nephritis.Forty-four patients from eight centres with newly diagnosed nephritis World Health Organization class III or IV were randomly assigned either (MMF) 2 g/day for 6 months intravenous cyclophosphamide (IVC) 0.75-1 g/m(2) monthly addition corticosteroids.Remission occurred 13 out 25 (52%) IVC group and 11 19 (58%) MMF (P = 0.70). There 12% 26% that achieved complete...
SUMMARY: Background: This is a multi‐centre study to determine cost efficiency and effectiveness of the Ministry Health centre haemodialysis continuous ambulatory peritoneal dialysis (CAPD) programme. Methods: Forty‐four 11 CAPD centres were enrolled in this 2001. Sixty patients, 30 from each modality, evaluated. Micro‐costing was used costs. Results: The number haemodialyses conducted ranged 402 23 000 procedures per year, while for CAPD, output 70 2300 patient months/year. Cost RM79.61...
While phase angle of bioimpedance analysis (BIA) has great survival-predicting value in dialysis populations, it is known to be higher male than female subjects. In this study, we aimed explore the factors influencing predictive and identify appropriate physics terms for normalizing capacitance (C) resistance (R).We formulated body capacitive index (BCI), C(BMI) (capacitance × height(2)/weight), resistive (BRI), R(BMI) (resistance weight/height(2)), CH(2) height(2)). We also studied H(2)/R,...
Kidney transplantation is the optimal therapy for majority of patients with end-stage renal disease. However, cost and health outcomes have not been assessed in a middle-income nation low volume transplantation, such as Malaysia.This study used microcosting methods to determine living deceased donor kidney adult pediatric recipients. The perspective was from Ministry Health Malaysia. Cost-effectiveness measures were per life year (LY) quality-adjusted LYs. time horizon lifetime transplant...
COVID-19 infection and kidney disease (KD) carry a considerable risk of mortality. Understanding predictors death KD may help improve management patient outcome.This is prospective multicentre observational study conducted in multiracial Asian country to identify acute injury (AKI) hospitalized patients from January June 2020.A total 6078 were included this study. Mean age was 37.3 (±16.8) years, 71% male, 59.4% Malay, 6.7% Chinese, 2.3% Indian 31.7% other ethnicities. AKI seen 3.5% while...
Personalized medicine in kidney transplantation has the potential to improve outcomes and reduce complications. The aim of this study was investigate influence single nucleotide polymorphisms genes encoding metabolizing enzymes (CYP3A5) transporters (ABCC2) on clinical (acute graft failure and/or acute tubular necrosis (ATN)) transplant recipients (KTR). This a multicenter, retrospective cohort where adult KTR who had undergone between 2020 2021 received tacrolimus-mycophenolate treatment...
Introduction Genetic variations can influence how kidney transplant recipients (KTRs) respond to immunosuppressive drugs. However, limited resources necessitate a cost-benefit analysis of pharmacogenetic testing determine its role in routine practice. This study investigated the cost-effectiveness three genetic polymorphisms (
Background: Muscle wasting, observed in patients with end-stage kidney disease and protein energy wasting (PEW), is associated increased mortality for those on hemodialysis (HD). Oral nutritional supplementation (ONS) nutrition counseling (NC) are treatment options PEW but research targeting muscle status, as an outcome metric, limited. Aim: We compared the effects of combined (ONS + NC) vs. NC alone status parameters HD PEW. Methods: This multi-center randomized, open label-controlled...
Tacrolimus (FK506) is a calcineurin inhibitor with narrow therapeutic index that exhibits large interindividual variation. Seventy-eight kidney transplant patients treated tacrolimus were recruited to study the correlation of dose adjusted trough level (level/dose; L/D) CYP3A5 and ABCB1 genotypes, as well mRNA copy number in blood. Patients genotyped for (C1236T, G2677T/A, C3435T) (G6986A), while transcript was determined by absolute quantification (real-time PCR) 46 patients. CYP3A5*3...
Personalised medicine is potentially useful to delay the progression of chronic kidney disease (CKD). The aim this study was determine effects CYP3A5 polymorphism in rapid CKD progression. This multicentre, observational, prospective cohort performed among adult patients (≥18 years) with estimated glomerular filtration rate (eGFR) ≥30 mL/min/1.73 m2, who had ≥4 outpatient, non-emergency eGFR values during three-year period. blood samples collected were analysed for CYP3A5*3 polymorphism....
Chronic kidney disease (CKD) patients may be more susceptible to adverse drug reactions (ADRs), given their complex medication regimen and altered physiological state driven by a decline in function. This study aimed describe the relationship between
Abstract Purpose To determine the incidence, demographic profile, background of reporters, causative agents, severity and clinical outcomes hepatic adverse drug reaction (ADR) reports in Malaysia using national ADR reporting database. Methods The recorded between 2000 2017 were retrospectively analysed to identify reports. trend characteristics cases described. Multivariate disproportionality analysis agents was performed generate signals ADRs. Results A total 2090 ADRs (1.77% all ADRs)...
Objective In the present study, we undertook to establish therapeutic equivalence with respect peritonitis and technique failure between Carex disconnect system (B. Braun Carex, Mirandola, Italy) standard Ultra (Baxter Healthcare, Tokyo, Japan) in patients on continuous ambulatory peritoneal dialysis (CAPD). Design This multicenter, parallel group, randomized controlled trial involved 363 prevalent CAPD from 8 centers. The primary endpoint was rate; secondary endpoints were technical...
Butyricimonas virosa is a Gram-negative bacillus, which was first discovered in rat faeces 2009. To date, only seven human infections have been reported literature. our knowledge, this the case of peritoneal dialysis (PD)-related peritonitis due to B. virosa. A 65-year-old Chinese man presented hospital with complaints dizziness and vomiting. On admission, drained dialysate cloudy. He empirically treated as PD-related intraperitoneal (IP) cefazolin, ceftazidime, gentamicin. isolated from...
We analyzed the efficacy and safety of an everolimus with reduced-exposure calcineurin inhibitor (EVR+rCNI) versus mycophenolic acid standard-exposure CNI (MPA+sCNI) regimen in Asian patients from TRANSFORM study.In this 24-month, open-label study, de novo kidney transplant recipients (KTxRs) were randomized (1:1) to receive EVR+rCNI or MPA+sCNI, along induction therapy corticosteroids.Of 2037 293 (EVR+rCNI, N = 136; 157). At month 24, was noninferior MPA+sCNI for binary endpoint estimated...
This study enrolled 112 patients from 16 Asian centres in countries demonstrating that enteric‐coated mycophenolate sodium is a safe and effective alternative to mofetil. The incidence of gastrointestinal upset was reduced.