A5077653708- Mosquito-borne diseases and control
- CRISPR and Genetic Engineering
- HIV/AIDS drug development and treatment
- Renal Transplantation Outcomes and Treatments
- CAR-T cell therapy research
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Pharmacogenetics and Drug Metabolism
- Computational Drug Discovery Methods
- Immunotherapy and Immune Responses
- Virus-based gene therapy research
- Nanowire Synthesis and Applications
- Immune responses and vaccinations
- Alzheimer's disease research and treatments
- Natural Compound Pharmacology Studies
- Cholinesterase and Neurodegenerative Diseases
- Chemotherapy-related skin toxicity
- Pharmacological Receptor Mechanisms and Effects
- Monoclonal and Polyclonal Antibodies Research
- Statistical Methods in Clinical Trials
- Pharmaceutical and Antibiotic Environmental Impacts
- Circular RNAs in diseases
- Nonmelanoma Skin Cancer Studies
- Antibiotic Use and Resistance
- Lipoproteins and Cardiovascular Health
Taylor's University
2017-2024
Universiti Teknologi MARA
2013
The University of Adelaide
2009
Antibiotic resistance is fast spreading globally, leading to treatment failures and adverse clinical outcomes. This review focuses on the mechanisms of top five threatening pathogens identified by World Health Organization's global priority list: carbapenem-resistant
Dihydropyrimidine dehydrogenase (DPD) is a pyrimidine catabolic enzyme involved in the initial and rate-limiting step of pathway toxic metabolites 5-fluorouracil (5-FU). Several studies have reported that deficiency DPD polymorphisms its gene are related to 5-FU toxicities death. Association between serum concentration toxicity has also been previously demonstrated. Hence, this study aims understand role DPYD variants level risk developing prevent adverse reactions maximize therapy outcome...
Tacrolimus (FK506) is a calcineurin inhibitor with narrow therapeutic index that exhibits large interindividual variation. Seventy-eight kidney transplant patients treated tacrolimus were recruited to study the correlation of dose adjusted trough level (level/dose; L/D) CYP3A5 and ABCB1 genotypes, as well mRNA copy number in blood. Patients genotyped for (C1236T, G2677T/A, C3435T) (G6986A), while transcript was determined by absolute quantification (real-time PCR) 46 patients. CYP3A5*3...
Cancer, also known as malignant tumour or neoplasm, is a leading cause of death worldwide. One distinct feature from normal cells that cancerous often overexpress protein on the cell membrane—for instance, overexpression human epidermal growth factor receptor 2. The expression specific surface acts marker differentiates and facilitates recognition cells. An emerging anticancer treatment, Antibody–Drug Conjugates (ADCs), utilises this unique to kill ADCs consist an antibody linked with...
Non-albicansCandida species have emerged as fungal pathogens that cause invasive infections, with many of these displaying resistance to commonly used antifungal agents. This study was confined studying the characteristics clinical isolates C. rugosa complex and pararugosa species.Seven one isolate were obtained from two tertiary referral hospitals in Malaysia. Their susceptibilities, biofilm, proteinase, phospholipase, esterase haemolysin activities characterized. Biofilms quantified using...
Abstract: Clustered Regions of Interspersed Palindromic Repeat (CRISPR)-based techniques have been utilized in various research areas, including agriculture, biotechnology, and medicine. With the use a short sequence guide RNA CRISPR-associated (Cas) protein, this technique allows for robust, site-specific manipulation genome, aiding researchers making important biomedical discoveries scientific advancements. In review, we explored applications CRISPR/Cas systems field parasitology...
Abstract Aim: To evaluate two cases of gemcitabine‐induced radiation recall in patients who were treated for localized pancreatic cancer, and review the literature. Methods: The (from a cohort 80 carcinoma) retrospectively identified using patient medical records. Prior publications through an English language literature search MEDLINE Ovid from January 1966 to October 2006, key words gemcitabine recall. Results: Both reactions limited gastrointestinal system, previous radiotherapy field. No...
BackgroundCarbapenem resistant organisms are known to risk the life of both immunocompromised and immunocompetent patients due their resistance towards drug last resort.In carbapenemaseproducing Enterobacteriaceae (CPE), carbapenemase genes serve as main reservoir carbapenem plasmidmediated transferability naïve Enterobacteriaceae.In this regard, CPE infections a global health issue hasty dissemination throughout world.The detection at earliest is crucial control its transmission.Several...
Coronavirus disease 2019 (COVID-19) induced by the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) has impacted lives and wellbeing of many people. This globally widespread poses a significant public health concern that urges to discover an effective treatment. review paper discusses effectiveness repurposed drugs used treat COVID-19 potential novel therapies for COVID-19. Among various drugs, remdesivir is only agent approved Food Drug Administration (FDA) On other hand,...