A5101826899- Thyroid Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Cancer Mechanisms and Therapy
- Cytokine Signaling Pathways and Interactions
- Phytochemical compounds biological activities
- Studies on Chitinases and Chitosanases
- Cancer, Hypoxia, and Metabolism
- Viral-associated cancers and disorders
- Hemoglobin structure and function
- Genetic Associations and Epidemiology
- PI3K/AKT/mTOR signaling in cancer
- Protein Structure and Dynamics
- S100 Proteins and Annexins
- interferon and immune responses
- Myofascial pain diagnosis and treatment
- Synthesis of β-Lactam Compounds
- Pain Management and Treatment
- Pharmacology and Obesity Treatment
- Ferroptosis and cancer prognosis
- Enzyme Structure and Function
- Advanced MRI Techniques and Applications
- Advanced Synthetic Organic Chemistry
- Vasculitis and related conditions
- Health, Environment, Cognitive Aging
Shanghai Xuhui Central Hospital
2020-2022
Second Military Medical University
2022
Changhai Hospital
2022
Tianjin Children's Hospital
2022
Tianjin University
2022
Tianjin Medical University
2022
Shenzhen University
2021
Thomas Jefferson University
2021
Beijing Tsinghua Chang Gung Hospital
2020
Tsinghua University
2020
S100 calcium-binding proteins such as S100B are elevated in primary malignant melanoma and used markers for this numerous other cancers. Wild-type p53 protein levels relatively low these cancer cells (i.e. when compared with without S100B) but RNA antisense to is introduced. This result implicates the down-regulation of consistent large decreases observed previously transient co-transfections (Lin, J., Blake, M., Tang, C., Zimmer, D., Rustandi, R. R., Weber, D. Carrier, F. (2001) J. Biol....
Adult undifferentiated embryonal sarcoma of the liver (UESL) is an aggressive malignant tumor. As UESL rare, literature predominantly includes case reports, with a limited number small series. The aim present study was to investigate presentation, treatment modalities and outcomes this rare series adult systematic review. A single-institution were retrospectively analyzed, review performed by searching MEDLINE, Web Science, EMBASE, Google Scholar database Cochrane Library. For all identified...
Cyclooxygenase-2 (COX-2) serves an important role in the carcinogenesis and progression of gastric cancer. Harmine (HM) paclitaxel (PTX) are reported as promising drug candidates for cancer therapy, but whether a synergistic anti-tumor effect HM combined with PTX exists human remains unknown. The present study evaluated effects and/or on cell proliferation apoptosis line, SGC-7901. inhibited dose-dependent manner. Both alone induced cells. combination exerted inhibition induction SGC-7901...
Objective: There is growing evidence that in adults, higher levels of handgrip strength (HGS) are linked to better cognitive performance. However, the relationship between HGS and performance has not been sufficiently investigated special cohorts, such as individuals with hypertension who have an intrinsically risk decline. Thus, purpose this study was examine adults using data from Global Ageing Adult Health Survey (SAGE). Methods: A total 4486 Chinese SAGE were included study. Absolute...
To investigate role of GKS1B and its relationship between STAT3/PD-L1 p-Akt in papillary thyroid carcinoma (PTC).Expression PD-L1 was determined PTC cell lines. overexpressed or knocked down by transfection with overexpression plasmids si-CKS1B. STAT3 inhibitor WP1066 used to suppress STAT3, Pembrolizumab block PD-L1. Cell viability invasion were evaluated MTT transwell assay, respectively. The expression p-STAT3, Akt, measured using Western blotting.Both protein levels mRNA CKS1B remarkably...
Papillary thyroid carcinoma (PTC) is the most common type of carcinoma.To investigate clinical significance programmed death ligand 1 (PD-L1) and phosphoinositide-dependent protein kinase (PDK1) in PTC.A total 194 PTC patients were recruited. Contralateral normal tissues obtained used as controls (n = 80). The expression levels PD-L1, PDK1 p-Akt determined using immunohistochemistry.The upregulated cancer compared to tissues. mean optical density (MOD) values significantly higher PD-L1...
Renal disease in children may lead to a continuous decline of renal function. Multimodal functional magnetic resonance imaging (fMRI) technology can provide quantitative evaluation function information. We investigated the feasibility intravoxel incoherent motion (IVIM) and diffusion kurtosis (DKI) based on 3.0T MRI for assessment normal then analyzed changes parameters during development.A total 132 with both kidneys were grouped according age: ≤1 year old, 1-≤2 years 2-≤3 3-≤10 10-≤14 old....
Thyroid cancer (TC) is the most common endocrine malignancy. Medullary thyroid carcinoma (MTC) derived from parathyroid follicle cells (C cells) secrete calcitonin, accounting for approximately 5-10% of all cancers. The malignancy between differentiated and undifferentiated has a relatively poor prognosis. In MTC tumor cells, RREB1 regulates differentiation via RAS-Raf-1-ELK3 signaling induce calcitonin secretion. Therefore, it easy to parafollicular canceration medullary carcinoma. Here, we...
Objective To detect the M-type phospholipase A2 receptor (PLA2R), and thrombospondin type-1 domain-containing 7A (THSD7A) expression in renal tissue levels of their antibodies adult idiopathic membranous nephropathy (IMN). Also to determine value two markers diagnosis IMN. Methods One hundred sixteen patients with biopsy-proven MN at Second Hospital Hebei Medical University from December 2014 August 2015 were enrolled, including 86 IMN, 10 HBV-MN stage V lupus nephritis (LN-V). Twenty...
Abstract Background To investigate whether respectively radial extracoporeal shock wave therapy (rESWT) or a combination of rESWT, Celecoxib and Eperisone (rESWT+C+E) are superior in reducing pain subjects with chronic nonspecific low back (cnsLBP) compared to C+E alone (a standard treatment this condition China). Methods 140 cnsLBP were randomly allocated rESWT (n=47), rESWT+C+E (n=45) (n=48) for four weeks. Outcome was evaluated using the Pain Self-Efficacy Questionnaire (PSEQ), Numerical...
Introduction To investigate clinical significance of YKL-40 in hepatocellular carcinoma (HCC) patients with hepatitis B (HBV) related cirrhosis. Material and methods The present prospective observational study included 129 cases HCC patients. Besides, 152 only cirrhosis 110 no were also enrolled during the same period. Additionally, 100 healthy individuals as control. Serum levels determined using ELISA method. Levels serum albumin, total bilirubin, alanine aminotransferase (ALT) aspartate...
To explore the correlation between activating transcription factor 4 (ATF4) and procalcitonin (PCT) expressions combined with RET mutation pathological staging clinical prognosis of sporadic medullary thyroid carcinoma (SMTC). Fifty cases (tumor tissue) SMTC diagnosed by clinicopathology were collected patients nodular goiter selected as normal control. The site was analyzed detection kit PCT ATF4 in Western blot immunohistochemistry. Multiple linear regression used to analyze risk factors...
Objective To evaluate the efficacy of flurbiprofen axetil for treatment break-through pain (BTP) in patients with metastatic bone cancer pain.Methods Ninety-seven complicated BTP were randomly divided into morphine group (M group,n =51) and (F =46).In M,immediate release sulfate was given orally,and single dose relief about 10％ to 15％ daily slow-release dose,and administration repeated until relieved.In F,flurbiprofen 50 mg infused intravenously over 30 min,and maximum 150 mg.The frequency...