Juan He

ORCID: 0000-0001-7060-086X
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About
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Research Areas
  • Ophthalmology and Visual Impairment Studies
  • Acute Ischemic Stroke Management
  • Corneal surgery and disorders
  • Cervical Cancer and HPV Research
  • Viral Infections and Vectors
  • Genetic Associations and Epidemiology
  • Ferroptosis and cancer prognosis
  • Intracerebral and Subarachnoid Hemorrhage Research
  • Cerebrovascular and Carotid Artery Diseases
  • Glaucoma and retinal disorders
  • Cancer-related Molecular Pathways
  • Cancer Immunotherapy and Biomarkers
  • Neurological Disease Mechanisms and Treatments
  • Viral-associated cancers and disorders
  • BRCA gene mutations in cancer
  • CAR-T cell therapy research
  • Biochemical Analysis and Sensing Techniques
  • Spinal Hematomas and Complications
  • Nuclear Structure and Function
  • Diverse Approaches in Healthcare and Education Studies
  • Colorectal and Anal Carcinomas
  • Regulation of Appetite and Obesity
  • Health, Environment, Cognitive Aging
  • Cutaneous lymphoproliferative disorders research
  • Genomics and Rare Diseases

Guangzhou Medical University
2025

Chongqing Medical University
2024

The Affiliated Yongchuan Hospital of Chongqing Medical University
2024

Wenzhou Medical University
2021-2024

Peking University Shenzhen Hospital
2022-2023

Sichuan University
2022

First Affiliated Hospital of Kunming Medical University
2022

Kunming Medical University
2022

Wuhan University
2021

Renmin Hospital of Wuhan University
2021

The present study was designed to investigate whether the extracellular signal-regulated kinase (ERK) signaling pathway, a downstream component of dopamine signaling, is involved in myopia among Chinese children.During 3.5-year follow-up, 488 primary school students were enrolled this study. Non-cycloplegic spherical equivalent refraction (SE) and other ocular parameters assessed. Four variants four genes ERK pathway selected: RASGRF1 rs6495367, PTPN5 rs1550870, PTPRR rs11178469, PDGFRA...

10.3389/fgene.2021.654869 article EN cc-by Frontiers in Genetics 2021-05-27

Nuclear transport factor 2 (NUTF2) is a GDP-binding protein that participates in the nucleocytoplasmic process. The role of NUTF2 cancer development largely unknown and lacks systemic assessment across human cancers. In this study, we performed pan-cancer analysis Out 33 types cancers, 19 had significantly different expression between tumor normal tissues. Meanwhile, survival showed could be an independent prognostic several types. Further suggested was correlated with infiltration immune...

10.3389/fonc.2022.829389 article EN cc-by Frontiers in Oncology 2022-01-28

Background. Epithelial ovarian cancer (EOC) is an extremely lethal gynecological malignancy and has the potential to benefit from immune checkpoint blockade (ICB) therapy, whose efficacy highly depends on complex tumor microenvironment (TME). Method Result. We comprehensively analyze landscape of TME its prognostic value through infiltration analysis, somatic mutation survival analysis. The results showed that high cells predicts favorable clinical outcomes in EOC. Then, detailed EOC had...

10.1155/2021/5523749 article EN cc-by Journal of Oncology 2021-08-26

To analyse the association of sleep quality with myopia under different genetic risk (GR) levels.A cross-sectional survey students aged 9-14y in Wenzhou, China, was conducted. Refraction without cycloplegia and ocular parameters were measured. Sleep assessed Pittsburgh Quality Index (PSQI). Seventeen single nucleotide polymorphisms (SNPs) replicated by analysis used to compute GR score (GRS). Possible confounders a questionnaire that collected information about children their parents....

10.18240/ijo.2022.10.14 article EN cc-by-nc-nd International Journal of Ophthalmology 2022-09-22

Abstract To discuss the status of epidemiology stroke in Mongolian and Han population aged over 45 years to understand treatment prevention stroke. Data collected on populations six areas Inner Mongolia were analyzed by using stratified multi-stage cluster sampling. The prevalence rate patients was 4.62%. increased with age both males females, populations, higher than females Mongolia. population. incidence 0.28%, which relapsed ischemic 23.29%. proportion hemorrhagic rates high. age....

10.1038/srep45710 article EN cc-by Scientific Reports 2017-04-04

Background Myopia is a complex multifactorial condition which involves several overlapping signaling pathways mediated by distinct genes. This prospective cohort study evaluated the associations of two genetic variants in TGF-β pathway with onset and progression myopia ocular biometric parameters Chinese school-aged children. Methods A total 556 second grade children were examined followed up for 3.5 years. Non-cycloplegic refraction measured annually. Multivariate regression analysis was...

10.3389/fcell.2021.628182 article EN cc-by Frontiers in Cell and Developmental Biology 2021-04-28

The aim of this study was to assess changes in sexual function after 980-nm diode laser vaporization the prostate.A total 82 benign prostatic hyperplasia (BPH) patients underwent from May 2013 December 2016, and were followed up for 12 months. following outcomes assessed at baseline, 6, months postoperatively: international prostate symptom score (IPSS), quality life (QoL) score, maximum urinary flow rate (Qmax), five-item version index erectile dysfunction questionnaire (IIEF-5), male...

10.1089/end.2018.0440 article EN Journal of Endourology 2018-09-06

Objective To investigate epidemiologically the prevalence of obesity and overweight in Mongolian Han residents aged over 55 years old pastoral area Inner Mongolia,China.Method From 2008 to 2009,with diagnostic criteria adopted by Chinese World Health Organization (WHO),an epidemiological investigation was carried out 9 146 subjects.Result The incidences were 32.43% (32.25% WHO criteria),19.09% (9.91%),and 33.60% (29.85%),15.19% (7.66%),respectively.The higher than that (x2...

10.3760/cma.j.issn.1000-6699.2014.06.004 article EN Zhonghua neifenmi daixie zazhi 2014-06-25

To analyze the prevalence of different degrees vascular cognitive impairment (VCI) in stroke and characteristics demography distribution Inner Mongolia. In order to provide reference data theoretical guidance for prevention treatment VCI after area.Stratified multi-stage random sampling was used extract six regions Mongolia as first cluster; then corresponding banners (counties) were selected randomly secondary according number patient required investigation, communities from cluster....

10.1080/00207454.2017.1408615 article EN International Journal of Neuroscience 2017-11-27
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