A5067464927- Macrophage Migration Inhibitory Factor
- Nuclear Receptors and Signaling
- Monoclonal and Polyclonal Antibodies Research
- Cell Adhesion Molecules Research
- Chemokine receptors and signaling
- Immune Cell Function and Interaction
- Cytokine Signaling Pathways and Interactions
- Cancer Cells and Metastasis
- Nitric Oxide and Endothelin Effects
- Synthesis and Biological Evaluation
- Vitamin K Research Studies
- Eosinophilic Esophagitis
- 3D Printing in Biomedical Research
- Protein Kinase Regulation and GTPase Signaling
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Protein Structure and Dynamics
- Angiogenesis and VEGF in Cancer
- Clinical Nutrition and Gastroenterology
- Immune Response and Inflammation
- Receptor Mechanisms and Signaling
- Neural Networks and Applications
- Retinoids in leukemia and cellular processes
- AI in cancer detection
- Advanced Biosensing Techniques and Applications
- Mast cells and histamine
Clinical Insights
2021
Rutgers, The State University of New Jersey
1995-2017
SUNY Downstate Health Sciences University
2011-2014
University of Kansas Medical Center
2012
Technion – Israel Institute of Technology
2012
Weizmann Institute of Science
1989-2009
Rutgers New Jersey Medical School
1995-2007
Pfizer (United Kingdom)
2007
Hahnemann University Hospital
1989-1994
Jagiellonian University
1992-1994
Methods for protein modeling and design advanced rapidly in recent years. At the heart of these computational methods is an energy function that calculates free system. Many functions were also developed to estimate consequence mutation on stability or binding affinity. In current study, we chose six different previously reported as being able predict change (ΔΔG) upon mutation: CC/PBSA, EGAD, FoldX, I-Mutant2.0, Rosetta Hunter. We evaluated their performance a large set 2156 single...
Chemokines orchestrate cell migration for development, immune surveillance, and disease by binding to surface heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors (GPCRs). The array of interactions between the nearly 50 chemokines their 20 GPCR targets generates an extensive signaling network which promiscuity biased agonism add further complexity. receptor CXCR4 recognizes both monomeric dimeric forms chemokine CXCL12, is a distinct example ligand bias in family....
Cytokines such as tumor necrosis factor (TNF)-alpha and interleukin (IL)-10 play significant roles in the inflammatory immune responses that mediate allograft rejection. The presence of a G-->A polymorphism at position -308 promoter region TNF-alpha gene increased its transcription 6- to 7-fold. A similar -1082 IL-10 results decreased production protein. In this study we have determined whether single nucleotide polymorphisms regions genes can predict outcome liver recipients.DNA was...
We present an algorithm that estimates dense planar-parallax motion from multiple uncalibrated views of a 3D scene. This generalizes the "plane+parallax" recovery methods to more than two frames. The parallax pixels across frames (relative planar surface) is related scene structure and camera epipoles. field, epipoles, are estimated directly image brightness variations frames, without precomputing correspondences.
An evaluation of the associative search network (ASN) learning scheme when used for control parameters robot motion is presented. The method impedance in which controlled variables are dynamic relations between manipulator's tip and forces exerted by tip. main task that wiping a surface whose geometry not precisely known. does use model its environment. It stochastic uses single scalar value as measure system performance. found to perform quite well. A few variants discussed. Modifying...
Many of the reactions cellular immunity are mediated by soluble lymphocyte-derived factors (lymphokines). One important category lymphokine action involves effects on cell motility. These have been described mainly with respect to inflammatory cells. In this report, we describe ability a lymphocyte product inhibit migration endothelial cells in system vitro. The responsible factor is distinct from previously mediator that inhibits tumor lymphocytes influence properties consistent data others...
Endothelial cells play a pivotal role in the development of atherosclerosis. An ‘activated’ phenotype these is manifested by signal transduction‐dependent expression genes encoding cytokines, pro‐ and anticoagulant factors, cell adhesion molecules. In current study we examined effect ouabain, an inhibitor Na + /K ‐ATPase, on process endothelial activation. We demonstrated that ouabain was able to stimulate VCAM‐1 potentiate IFN‐γ this process. Moreover, provided complementary for either TNF...
Nutrition and Immunology: Principles PracticeEditors: GERSHWIN, M. Eric, M.D. (UC Davis); GERMAN, J. Bruce, Ph.D. KEEN, Carl L., Davis)Bibliographic Data: ISBN: 0-896037-19-3, Humana Press, 2000, $149.50) 505 pages, Contributors, hard cover Audiences: Immunologists, Nutritionists Subjects: Immunology, Nutrition, Public Health Other Info: The book contains predominantly black-and-white illustrations, with some color illustrations. Description: This is focused heavily on diet its role in...
Summary Supernatants with macrophage migration inhibition factor (MIF) activity were obtained from cultures of antigen-stimulated guinea pig and human lymphocytes, SV40-infected monkey kidney cells. The but not preparations effective in inhibiting mastocytoma cells as well macrophages. This was associated cytotoxicity reversible.
Abstract Lymphokine-containing supernatants derived from seven different human lymphoid cell lines and lymphokine-containing concanavalin Astimulated murine lymphocytes were found to be capable of reversibly inhibiting the migration tumor cells in vitro. The used these studies P815 mastocytoma, Ehrlich ascites, Walker carcinosarcoma, Hepatoma 129, Sarcoma 37. Preliminary physicochemical evidence suggests that mediator, here termed TMIF, is distinct MIF. In any case, results suggest...
It is quite common that multiple human observers attend to a single static interest point. This known as mutual awareness event (MAWE). A preferred way monitor these situations with camera captures the while using existing face detection and head pose estimation algorithms. The current work studies underlying geometric constraints of MAWEs reformulates them in terms image measurements. are then used method 1) detects whether such an point does exist, 2) determines where it located, 3)...
Macrophage migration inhibition factor (MIF) derived from human lymphoid cell lines was found to lose biologic activity on dialysis. Although not recovered in the dialyzate, mixing experiments demonstrated that components retentate and dialyzate could reassociate restore activity. The fragment of larger molecular weight (< 10,000) inhibit intact MIF, whereas smaller (5,000 not. These findings suggest MIF is composed at least two noncovalently linked subunits. In analogy situation for certain...
Abstract The adherence of cells to microvascular endothelium is important in a number processes, including inflammatory responses and metastasis. It has been demonstrated that human models, cytokines such as TNF, IL-1, IFN-gamma increase the adhesiveness for immune system by stimulating expression cell adhesion molecules on endothelial surfaces. We others have shown similar cytokine-induced tumor murine models. In contrast effect those modulators, transforming growth factor-beta (TGF-beta)...