A5069940448- Chemokine receptors and signaling
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Receptor Mechanisms and Signaling
- Systemic Lupus Erythematosus Research
- Angiogenesis and VEGF in Cancer
- Proteoglycans and glycosaminoglycans research
- T-cell and B-cell Immunology
Medical College of Wisconsin
2015-2023
Aurora West Allis Medical Center
2023
Chemokines orchestrate cell migration for development, immune surveillance, and disease by binding to surface heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors (GPCRs). The array of interactions between the nearly 50 chemokines their 20 GPCR targets generates an extensive signaling network which promiscuity biased agonism add further complexity. receptor CXCR4 recognizes both monomeric dimeric forms chemokine CXCL12, is a distinct example ligand bias in family....
Chemokines are secreted proteins that direct the migration of immune cells and involved in numerous disease states. For example, CCL21 (CC chemokine ligand 21) CCL19 19) recruit antigen-presenting dendritic naïve T-cells to lymph nodes thought play a role node metastasis CCR7 receptor 7)-expressing cancer cells. many receptors, N-terminal posttranslational modifications, particularly sulfation tyrosine residues, increases affinity for ligands may contribute bias. Chemokine sulfotyrosine (sY)...