A5013817030- Proteoglycans and glycosaminoglycans research
- Immune Cell Function and Interaction
- Genomics and Chromatin Dynamics
- Cancer-related molecular mechanisms research
- Autopsy Techniques and Outcomes
- RNA modifications and cancer
- RNA Research and Splicing
- Chemokine receptors and signaling
- Cellular transport and secretion
- Genetics and Neurodevelopmental Disorders
- Genomics and Phylogenetic Studies
- Genomics and Rare Diseases
- Animal Genetics and Reproduction
- Cancer Genomics and Diagnostics
- Ethics and Legal Issues in Pediatric Healthcare
- RNA and protein synthesis mechanisms
- Angiogenesis and VEGF in Cancer
- CAR-T cell therapy research
- RNA regulation and disease
- Genetic and rare skin diseases.
- Prenatal Screening and Diagnostics
- T-cell and B-cell Immunology
- RNA Interference and Gene Delivery
- Erythrocyte Function and Pathophysiology
- Immunotherapy and Immune Responses
Austin Health
2023
New York University
2016-2020
Yale University
2014-2019
NYU Langone’s Laura and Isaac Perlmutter Cancer Center
2016
University of California, Berkeley
2015
University of New Haven
2014
Yeshiva University
2001
Albert Einstein College of Medicine
1997-2001
Immune cells, including natural killer (NK) recognize transformed cells and eliminate them in a process termed immunosurveillance. It is thought that tumor evade immunosurveillance by shedding membrane ligands bind to the NKG2D-activating receptor on NK and/or T desensitize these cells. In contrast, we show mice, shed form of MULT1, high-affinity NKG2D ligand, causes cell activation rejection. Recombinant soluble MULT1 stimulated rejection mice. Soluble functions, at least part,...
Posttranscriptional regulation plays a crucial role in shaping gene expression. During the maternal-to-zygotic transition (MZT), thousands of maternal transcripts are regulated. However, how different
For those searching for human disease-causing genes, information on the position of genes with respect to genetic markers is essential. The physical map composed ESTs and provides positional these as well starting point gene identification in form genomic clones containing exons. To facilitate effort region spanning D12S1629 D12S312 , we constructed a high-resolution transcript PAC/BAC/cosmid clones. strategy construction such involved utilization STSs screening large insert bacterial...
Abstract Post-transcriptional regulation is crucial to shape gene expression. During the Maternal-to-Zygotic Transition (MZT), thousands of maternal transcripts are regulated upon fertilization and genome activation. Transcript stability can be influenced by cis- elements trans- factors, but how these inputs integrated determine overall mRNA unclear. Here, we show that most under combinatorial multiple decay pathways during zebrafish MZT. To identify cis -regulatory elements, performed a...
Abstract NKG2D is one of the most important activating receptors expressed by NK cells in terms tumor cell recognition. binds to different ligands, and triggers cytolysis cytokine release cells. Certain human ligands can be shed are thought inhibit NK-mediated surveillance cancer. Here we showed that a mouse ligand, MULT1, cleaved efficiently from cells, accumulates serum tumors inflammatory diseases. Cleaved MULT1 with high affinity (~10 nM). Remarkably, an engineered form when secreted...