The postsynthetic modification strategy is adopted to demonstrate for the first time syntheses of catalytically active chiral MOPMs from a preassambled achiral framework, MIL-101, by attaching L-proline-derived catalytic units open metal coordination sites host framework. Various characterization techniques (including PXRD, TGA, IR, and N(2) absorption measurements) indicated that are successfully incorporated into keeping parent framework intact. new show remarkable activities in asymmetric...

Signal amplification by enzyme labels in enzyme-linked immunosorbent assays (ELISAs) is not sufficient for detecting a low number of bacterial pathogens. It useful to employ approaches that involve multiple signal such as enzymatic plus redox cycling. An advantageous combination an product [for fast electrochemical-chemical-chemical (ECC) cycling involves the product] and substrate (for slow side reactions ECC substrate) has been developed obtain detection limit E. coli O157:H7...

The authors herein report optimized conditions for ultrasensitive phosphatase-based immunosensors (using redox cycling by a reducing agent) that can be simply prepared and readily applied to microfabricated electrodes. were the detection of cardiac troponin I in human serum. preparation an immunosensing layer was based on passive adsorption avidin (in carbonate buffer (pH 9.6)) onto indium–tin oxide (ITO) allows very low levels nonspecific binding proteins. optimum enzymatic reaction...

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA chiral stationary phase for the facile resolution of amino acids, alcohols and amines as N-3,5-dinitrobenzoyl derivativesWilliam H. Pirkle Myung Ho HyunCite this: J. Org. Chem. 1984, 49, 17, 3043–3046Publication Date (Print):August 1, 1984Publication History Published online1 May 2002Published inissue 1 August 1984https://pubs.acs.org/doi/10.1021/jo00191a001https://doi.org/10.1021/jo00191a001research-articleACS PublicationsRequest reuse...

Crown ether-based HPLC chiral stationary phases (CSPs) have been successfully utilized in the resolution of various racemic compounds containing a primary amino group. Especially, CSPs based on crown ethers incorporating binaphthyl unit or tartaric acid and phenolic pseudo shown high recognition efficiency. In this account paper, review development etherbased CSPs, their structural characteristics applications to including drugs secondary group with variation type content mobile phase...

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA chiral recognition model for the chromatographic resolution of N-acylated 1-aryl-1-aminoalkanesWilliam H. Pirkle, Christopher J. Welch, and Myung Ho HyunCite this: Org. Chem. 1983, 48, 25, 5022–5026Publication Date (Print):December 1, 1983Publication History Published online1 May 2002Published inissue 1 December 1983https://pubs.acs.org/doi/10.1021/jo00173a045https://doi.org/10.1021/jo00173a045research-articleACS PublicationsRequest reuse...

Two new anthracene thiourea derivatives, 1 and 2, were investigated as fluorescent chemosensors for the chiral recognition of two enantiomers alpha-amino carboxylates. Especially, host 2 displayed K(L)/K(D) values high 10.4 with t-Boc alanine. Furthermore, D/L selectivity hosts is opposite, even though both bear same glucopyranosyl units. These intriguing opposite binding affinities by obtained without/with H-pi interaction between anthrancene moiety methyl groups, which explained extensive...

Abstract Two novel alternating π‐conjugated copolymers, poly[2,8‐(6,6′,12,12′‐tetraoctyl‐6,12‐dihydroindeno‐[1,2b]fluorene‐ alt ‐5(1‐(2,6‐diisopropylphenyl)‐2,5‐di(2‐thienyl)pyrrole) ( P1 ) and ‐5(1‐(p‐octylphenyl)‐2,5‐di(2‐thienyl)pyrrole) P2 ), were synthesized via the Suzuki coupling method their optoelectronic properties investigated. The resulting polymers completely soluble in various common organic solvents weight‐average molecular weights M w 5.66 × 10 4 (polydispersity: 1.97) 2.13×...

We report an interference-free electrochemical lateral-flow immunoassay that enables one-step ultrasensitive detection with serum.

Abstract Crown ether‐based chiral stationary phases (CSPs) have been known to be quite useful for the liquid chromatographic resolution of racemic compounds containing a primary amino group. Chiral separations on crown CSPs are characterized by several factors. In this paper, structural characteristics five selected CSPs, analyte and factors characterizing such as mobile phase modifiers column temperature were reviewed. Among various factors, inorganic modifier in influence equally CSPs....

A highly efficient random copolymer showing a record PCE of 7.03% was prepared.

Pyrrolo[3,4-c]pyrrole-1,3(2H,5H)-dione (DPPD)-based large band gap polymers, P(BDT-TDPPDT) and P(BDTT-TDPPDT), are prepared by copolymerizing electron-rich 4,8-bis(2-ethylhexyloxy)benzo[1,2-b:4,5-b′]dithiophene (BDT) or 4,8-bis(5-(2-ethylhexyl)thiophen-2-yl)benzo[1,2-b:4,5-b′]dithiophene (BDTT) unit with novel electron deficient 2,5-dioctyl-4,6-di(thiophen-2-yl)pyrrolo[3,4-c]pyrrole-1,3(2H,5H)-dione (TDPPDT) unit. The absorption bands of polymers P(BDTT-TDPPDT) cover the region from 300 to...

A chiral stationary phase (CSP) prepared by bonding (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid to silica gel was used for the direct resolution of β-amino acids. To determine optimum mobile composition, two acids were selected and their resolutions on CSP performed with variation types contents organic acidic modifiers in aqueous phase. The chromatographic behaviors found be dependent From results these experiments, a possible composition proposed mixed solvent 50% methanol water...

Abstract The preparation of 3,5-dinitrophenyl carbamates and ureas from chiral alcohols amines 3,5-dinitrobenzoyl azide is described. These have been observed to resolve on α-arylalkylamine based stationary phases 1 2. A mechanism for the resolution these presented compared thereof analogous series 3,5-dinitrobenzamides phases.

Abstract Liquid chromatographic chiral stationary phases (CSPs) based on crown ethers have been successfully utilized in the separation of enantiomers various racemic compounds containing a primary amino group. Especially, CSPs incorporating binaphthyl unit or tartaric acid most successful. In this review, development unit, their applications to resolution and non‐primary with variation type content organic, acidic, inorganic modifiers an aqueous mobile phase non‐aqueous efforts improve...

Magnetic silica nanoparticles modified by a chiral selector were demonstrated to be useful in magnetic field induced separation of enantiomers.