A5048139958- Environmental Conservation and Management
- Energy, Environment, Agriculture Analysis
- Agriculture Sustainability and Environmental Impact
- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Protein Structure and Dynamics
- Environmental Impact and Sustainability
- Bioenergy crop production and management
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Forest Management and Policy
- RNA and protein synthesis mechanisms
- Peptidase Inhibition and Analysis
- Cardiac, Anesthesia and Surgical Outcomes
- Radiopharmaceutical Chemistry and Applications
- Recycling and Waste Management Techniques
- Environmental Policies and Emissions
- Neuropeptides and Animal Physiology
- Land Use and Ecosystem Services
- Healthcare cost, quality, practices
- bioluminescence and chemiluminescence research
- Enzyme Structure and Function
- Material Properties and Processing
- Yersinia bacterium, plague, ectoparasites research
- 3D Modeling in Geospatial Applications
Radboud University Nijmegen
2023-2025
Radboud University Medical Center
2023-2025
Geneeskundige en Gezondheidsdienst
2024
Louis Bolk Instituut
2019-2023
University of Washington
2021-2022
Eindhoven University of Technology
2020-2021
Amsterdam UMC Location Vrije Universiteit Amsterdam
2012
Abstract Heterogeneous immunoassays such as ELISA have become indispensable in modern bioanalysis, yet translation into point-of-care assays is hindered by their dependence on external calibration and multiple washing incubation steps. Here, we introduce RAPPID (Ratiometric Plug-and-Play Immunodiagnostics), a mix-and-measure homogeneous immunoassay platform that combines highly specific antibody-based detection with ratiometric bioluminescent readout. The concept entails analyte-induced...
Asymmetric multiprotein complexes that undergo subunit exchange play central roles in biology but present a challenge for design because the components must not only contain interfaces enable reversible association also be stable and well behaved isolation. We use implicit negative to generate β sheet–mediated heterodimers can assembled into wide variety of complexes. The designs are stable, folded, soluble isolation rapidly assemble upon mixing, crystal structures close computational...
Abstract Background Prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) is currently under evaluation for detecting clinically significant prostate cancer. The PSMA-PET/CT may complement the current standard diagnostic pathway cancer, which includes prostate-specific (PSA) testing and multiparametric magnetic resonance imaging (mpMRI). This study evaluated cost-effectiveness quality of life impact incorporating into this algorithm. Methods A...
Samenvatting In de afgelopen jaren wordt term ‘theranostics’ steeds vaker gebruikt. Een nieuwe, reeds welbekende, theranostic of radioligand -therapie (RLT) is 177 Lu-PSMA, waarmee patiënten met gemetastaseerd castratieresistent prostaatcarcinoom (mCRPC) behandeld worden. Het een radioactief gelabeld medicijn dat intraveneus toegediend, meestal in 4–6 cycli. De bètastraling veroorzaakt celdood van prostaatkankercellen PSMA-expressie. radioactieve gammaverval kan gebruikt worden voor...
Abstract Heterogeneous immunoassays such as ELISA have become indispensable in modern bioanalysis, yet translation into easy-to-use point-of-care assays is hindered by their dependence on external calibration and multiple washing incubation steps. Here, we introduce RAPPID ( Ra tiometric P lug-and- lay Immuno d iagnostics), a “mix-and-measure” homogeneous immunoassay platform that combines highly specific antibody-based detection with ratiometric bioluminescent readout can be detected using...
Abstract Asymmetric multi-protein complexes that undergo subunit exchange play central roles in biology, but present a challenge for protein design. The individual components must contain interfaces enabling reversible addition to and dissociation from the complex, be stable well behaved isolation. Here we employ set of implicit negative design principles generate beta sheet mediated heterodimers which enable generation wide variety structurally defined asymmetric assemblies. Crystal...
De oorlogschirurgie is al eeuwenlang de bakermat voor medische vernieuwingen. Het dan ook niet verbazingwekkend dat in Tweede Wereldoorlog basis werd gelegd trombo-elastometrie, een manier om stollingsstoornissen door grote bloedingen op te sporen. nieuwste trombo-eleastografen, waaronder ROTEM ®, zijn staat stollingsstatus van patiënt binnen afzienbare tijd helder krijgen zodat er adequate maatregelen genomen kunnen worden.