A5101546677- Lysosomal Storage Disorders Research
- Trypanosoma species research and implications
- Cellular transport and secretion
- Carbohydrate Chemistry and Synthesis
- Glycogen Storage Diseases and Myoclonus
- Image Processing Techniques and Applications
- Osteoarthritis Treatment and Mechanisms
- Genomics and Rare Diseases
- DNA Repair Mechanisms
- Parasitic Diseases Research and Treatment
- Genetic factors in colorectal cancer
- Metabolism and Genetic Disorders
- Optical Systems and Laser Technology
- Neurological Disease Mechanisms and Treatments
- RNA regulation and disease
- Mitochondrial Function and Pathology
- Research on Leishmaniasis Studies
- Neonatal and fetal brain pathology
- Cystic Fibrosis Research Advances
- Mosquito-borne diseases and control
- Optical measurement and interference techniques
- Biomedical Research and Pathophysiology
- Connective tissue disorders research
- Calcium signaling and nucleotide metabolism
- Child Nutrition and Feeding Issues
Capital Medical University
2020-2024
Beijing Friendship Hospital
2020-2024
Capital University
2024
Peking University
2024
Tianjin University of Technology and Education
2024
Chinese PLA General Hospital
2020
Abstract Fibroblast growth factor 18 (FGF18) emerges as a promising therapeutic target for osteoarthritis (OA). In this study, novel articular cavity‐localized lipid nanoparticle (LNP) named WG‐PL14 is developed. This optimized formulation has nearly 30‐fold increase in mRNA expression well better cavity enrichment compared to commercial lipids MC3 when performing intra‐articular injection. Then, sequence encoding recombinant human FGF18 (rhFGF18) potential therapy OA optimized. vitro assays...
Abstract Objectives Sanfilippo syndrome (Mucopolysaccharidosis III, MPS III) is a rare autosomal recessive hereditary disease, which caused by lysosomal enzyme deficiency. This study was operated to investigate clinical and molecular characteristics of patients with will improve the diagnosis treatment III. Method Thirty four III were assessed using evaluation, questionnaire, scoring system. Results Among 34 patients, 14 had IIIA, 19 B, one C. Speech delay (100%) intellectual disability most...
Neonatal hypoxic-ischemic encephalopathy, an important cause of death as well long-term disability in survivors, is caused by oxygen and glucose deprivation, limited blood flow. Following injury the neonatal brain, three main biochemical damages (excitotoxicity, oxidative stress, exacerbated inflammation) are triggered. Mitochondria involved all cascades. nexus metabolic pathways to offer most energy that our body needs. Hypoxic-ischemic affects characteristics mitochondria, including...
Through a systematic review of relevant literature, this paper comprehensively elucidates the evolution camera calibration techniques and analyzes key milestones in its development. It introduces traditional calibration, self-calibration, neural network-based methods along with their research status, summarizing characteristics applicable scenarios each method practical applications. Based on latest progress, it delineates technologies field highlighting respective advantages limitations....
Objective To summarize the phenotypic features of an unrecognized leukoencephalopathy in infants sharing same clinical features, and to better understand disease provide new evidence for identification leukoencephalopathy. Methods Clinical follow-up data 13 patients with infantile were collected from Peking University First Hospital January, 2006 December, 2014. Results (1) There 7 male 6 female.The average age onset was 11 months (4-25 months). Thirty-eight percent(5/13...
Abstract Background Gaucher disease, an autosomal recessive lysosomal storage disorder, is characterized by progressive of glucocerebroside in macrophages predominantly bone, bone marrow, liver, and spleen. Meta-analysis global disease epidemiology was not available prior to this study. Methods To provide a systematic review meta-analysis birth prevalence multiple countries. MEDLINE EMBASE databases were searched for original research articles on the from inception until July 21, 2021....