A5025649625- Graphene and Nanomaterials Applications
- MXene and MAX Phase Materials
- Single-cell and spatial transcriptomics
- Advanced Photocatalysis Techniques
- T-cell and B-cell Immunology
- 3D Printing in Biomedical Research
- Immunotherapy and Immune Responses
- Intensive Care Unit Cognitive Disorders
- Global Health and Surgery
- Graphene research and applications
- Mathematical Biology Tumor Growth
- Spaceflight effects on biology
- Anesthesia and Neurotoxicity Research
- Planarian Biology and Electrostimulation
- Electrospun Nanofibers in Biomedical Applications
- Advanced Memory and Neural Computing
- HIV Research and Treatment
- Ammonia Synthesis and Nitrogen Reduction
- Boron and Carbon Nanomaterials Research
- Virus-based gene therapy research
- Cell Image Analysis Techniques
University of Virginia
2021-2025
McCormick (United States)
2025
University of Brighton
2018-2021
Brighton Hospital
2021
The wearable artificial kidney can deliver continuous ambulatory dialysis for more than 3 million patients with end-stage renal disease. However, the efficient removal of urea is a key challenge in miniaturizing device and making it light small enough practical use. Here, we show that two-dimensional titanium carbide (MXene) composition Ti3C2Tx, where Tx represents surface termination groups such as −OH, −O–, −F, adsorb urea, reaching 99% efficiency from aqueous solution 94% dialysate at...
ABSTRACT Antibody production is central to protection against new pathogens and cancers, as well certain forms of autoimmunity. Antibodies often originate in the lymph node (LN), specifically at extrafollicular border B cell follicles, where T lymphocytes physically interact drive maturation into antibody-secreting plasmablasts. In vitro models this process are sorely needed predict aspects human immune response. Microphysiological systems (MPSs) offer opportunity approximate lymphoid...
The lymph node (LN) performs essential roles in immunosurveillance throughout the body. Developing vitro models of this key tissue is great importance to enhancing physiological relevance immunoengineering. LN consists stromal populations and immune cells, which are highly organized bathed constant interstitial fluid flow (IFF). stroma, notably fibroblastic reticular cells (FRCs) lymphatic endothelial (LECs), play crucial guiding T cell migration known be sensitive flow. During inflammation,...
On-chip 3D culture systems that incorporate immune cells such as lymphocytes and stromal are needed to model organs in engineered organs-on-chip. Photocrosslinking is a useful tool for creating immune-competent hydrogel cultures with spatial cell organization. However, loss of viability motility photocrosslinked gels can limit its utility, especially when working fragile primary cells. We hypothesized optimizing photoexposure-induced ROS production, porosity or combination both factors was...
Graphene and titanium carbide MXene variants significantly reduced bacterial endotoxin induced THP-1 monocyte IL-8, IL-6 TNF-α cytokine production.
Sepsis is a complex clinical syndrome that features excessive release of cytokines and other inflammatory mediators could lead to organ dysfunction. Despite different treatment management options, sepsis associated high morbidity mortality rates remain. This has prompted intensive research into alternative therapeutic approaches such as targeted removal related molecules using extracorporeal hemoperfusion. In this study, we explore the use graphene nanoplatelets (GNP) low-cost hemosorbents...
The lymph node (LN) performs essential roles in immunosurveillance throughout the body. Developing vitro models of this key tissue is great importance to enhancing physiological relevance immunoengineering. LN consists stromal populations and immune cells, which are highly organized bathed constant interstitial flow. stroma, notably fibroblastic reticular cells (FRCs) lymphatic endothelial (LECs), play crucial guiding T cell migration known be sensitive fluid During inflammation, flow rates...