A5053662322- Atrial Fibrillation Management and Outcomes
- Cardiac Imaging and Diagnostics
- Cardiac, Anesthesia and Surgical Outcomes
- Breast Cancer Treatment Studies
- Global Cancer Incidence and Screening
- Acute Myocardial Infarction Research
- Cardiac Valve Diseases and Treatments
- Statistical Methods in Clinical Trials
- Cervical Cancer and HPV Research
- Lung Cancer Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Sarcoma Diagnosis and Treatment
- Cardiac Health and Mental Health
- Lung Cancer Treatments and Mutations
- Health disparities and outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Coronary Interventions and Diagnostics
- COVID-19 Clinical Research Studies
- Colorectal Cancer Screening and Detection
- Cardiovascular Function and Risk Factors
- Statistical Methods and Bayesian Inference
- Genital Health and Disease
- Genetic Associations and Epidemiology
- Bone Tumor Diagnosis and Treatments
- Advanced Causal Inference Techniques
Case Western Reserve University
2022-2025
Program Support Center
2022-2025
University School
2022-2025
VA Boston Healthcare System
2022-2024
The Coordinating Center
2024
Health Services Research & Development
2019-2022
Durham VA Health Care System
2021-2022
Durham VA Medical Center
2019-2022
Duke University
2019-2022
VA Office of Research and Development
2022
When planning a randomized clinical trial, careful consideration must be given to how participants are selected for various arms of study. Selection and accidental bias may occur when not assigned study groups with equal probability. A simple random allocation scheme is process by which each participant has likelihood being treatment versus referent groups. However, chance an unequal number individuals arm the thus decrease power detect statistically significant differences between Block...
Meningiomas often contain steroid hormone receptors, but the correlation of receptor presence with patient outcome or mitotic index is unclear. Intracranial meningiomas from 70 patients (27 males and 43 females, mean age 52.9 + 1.7 years [mean +/- standard error mean], range 15-78 years) were evaluated immunocytochemically for female sex receptors using specific monoclonal antibodies. Prognostic correlations determined statistical analyses that included clinical histological variables....
Abstract The novel extracellular matrix structures called fractones are found in the lateral ventricle walls, principal adult brain stem cell niche. By electron microscopy, were shown to contact neural and progenitor cells (NSPC), suggesting a role neurogenesis. Here, we investigated spatial relationships between proliferating NSPC identified basic components first function of fractones. Using bromodeoxyuridine (BrdU) for birth-dating mouse wall, most mitotic next fractones, although some...
Abstract The relationship between status of the surgical margin and local control soft tissue sarcoma extremities by preoperative radiation therapy has been assessed in 132 consecutive patients from 1974 to 1988. 5‐year actuarial rate was 94% for all patients; rates were 97% 82% 104 tumors with negative marigins 28 positive margins, respectively. independent extent margin. For primary sarcomas, 96%, 97%, 100%, respectively, margins that at ≤1 mm or > 1 mm, specimens tumor; results 83%....
For patients with invasive bladder cancer the usual recommended treatment is radical cystectomy, although transurethral resection of tumor, systemic chemotherapy, and radiotherapy are each effective in some patients. We sought to determine whether these treatments combination might be as cystectomy thus allow preserved cured.
Background. Chordomas are uncommon primary malignant tumors of bone that typically occur in the axial skeleton including sacrum, vertebrae, and skull base. The base usually not amenable to complete surgical resection, most require postoperative radiotherapy. natural history chordoma is typified by slow locally invasive tumor progression eventual death, although few parameters known allow stratification patients into prognostic groups. Methods. Sixty-two with chordomas treated at...
Abstract Aims To evaluate the effects of a breastfeeding intervention on primiparous mothers' self‐efficacy, duration and exclusivity at 4 8 weeks postpartum. Background Few studies have examined self‐efficacy improved outcomes among mothers in China. Design An experimental pre‐test posttest, two‐group design was used study. Methods A total 74 participants were recruited to study from tertiary hospital central China, June–October 2012. individualized, standardized nursing based Self‐Efficacy...
Lipid peroxides and their reactive aldehyde derivatives (LPPs) have been linked to obesity-related pathologies, but whether they a causal role has remained unclear. Glutathione peroxidase 4 (GPx4) is selenoenzyme that selectively neutralizes lipid hydroperoxides, human gpx4 gene variants associated with obesity cardiovascular disease in epidemiological studies. This study tested the hypothesis LPPs underlie cardio-metabolic derangements using high fat, sucrose (HFHS) diet haploinsufficient...
Background Onset of postoperative atrial fibrillation ( POAF ) is a common and costly complication heart surgery despite major improvements in surgical technique quality patient care. The etiology , the ability clinicians to identify therapeutically target high‐risk patients, remains elusive. Methods Results Myocardial tissue dissected from right appendage RAA was obtained 244 patients undergoing cardiac surgery. Reactive oxygen species ROS generation multiple sources assessed this tissue,...
Triple negative breast cancer (TNBC) is an aggressive subtype that accounts for 15-20% of cases, with a higher incidence relapse/death. Even adjuvant chemotherapy, the 5 year distant metastasis-free survival rate remains low. A total 452 tumor registry patients TNBC and no evidence metastatic disease were identified over period 1996-2011. The median age follow-up time 51 (range=21-88) 3.9 (range=0.14-14) years. Approximately 75% stage III received neoadjuvant chemotherapy (NACT) compared 47%...
Objective The authors investigated the combined experience of a single institution in treating bile duct carcinoma during modern era. Summary Background Data Bile carcinomas are notoriously difficult to cure, with locoregional recurrence rule, even after radical resection. Adjuvant efforts have included various radiation modalities, limited success. Recently, charged-particle radiotherapy has also been used these patients. Methods performed retrospective chart analysis 129 patients...
To study anal intraepithelial neoplasia and its associations with cervical human papillomavirus (HPV), neoplasia, host immune status, demographic behavioral risk factors in women at for HIV infection.Point-prevalence analysis nested within a prospective of seen three clinical centers the Women's Interagency Study.In 2001-2003 participants were interviewed, received gynecological examination, cytology testing and, if abnormal, colposcopy-guided or anoscopy-guided biopsy visible lesions....
To examine the relationships of social support and coping strategies to health-related quality life among primary caregivers stroke survivors in China.Caring for a survivor is highly stressful, which can negatively affect caregiver's physical psychological well-being. Stroke generally report more somatic symptoms, depressive sleep disorders isolation. They have poorer than general population.A cross-sectional, descriptive, correlational study.A quasi-random, point reference sample 121...
Background: Black women have the highest prevalence of hypertension in world. Reasons for this disparity are poorly understood. The historical legacy medical maltreatment Blacks U.S. provides some insight into distrust profession, refusal treatment, and poor adherence to treatment regimens. Methods: (N=80) who were prescribed antihypertensive medications recruited from urban communities North Carolina. Study participants completed Trust Physician Hill-Bone Compliance High Blood Pressure...
Background: Navigational bronchoscopy is utilized to guide biopsies of peripheral lung nodules and place fiducial markers for treatment limited stage cancer with stereotactic body radiotherapy. The type sedation used this procedure remains controversial. We performed a retrospective chart review evaluate the differences diagnostic yield overall success based on anesthesia type. Methods: Electromagnetic navigational was using superDimension software system. Once targeted lesion within reach,...
Treatment of giant-cell tumor bone generally involves wide en bloc resection the lesion and surrounding or curettage with without bone-grafting use cement. Radiation therapy has been used for patients who cannot be operated on medical reasons have a that is technically difficult to resect resected because its location. We performed present study evaluate efficacy megavoltage radiation in terms lack progression treatment-related morbidity.Twenty had were managed single course (forty seventy...