A5039085433- Multiple Myeloma Research and Treatments
- Protein Degradation and Inhibitors
- Anesthesia and Pain Management
- Eicosanoids and Hypertension Pharmacology
- Immune Response and Inflammation
- Advanced Glycation End Products research
- Cardiac Ischemia and Reperfusion
- Ubiquitin and proteasome pathways
- Acute Kidney Injury Research
- Anesthesia and Neurotoxicity Research
- Inflammasome and immune disorders
- Acute Myeloid Leukemia Research
- Cancer, Stress, Anesthesia, and Immune Response
- Heme Oxygenase-1 and Carbon Monoxide
- Genomics, phytochemicals, and oxidative stress
- Inflammatory mediators and NSAID effects
- Advanced battery technologies research
- Cancer Treatment and Pharmacology
- MicroRNA in disease regulation
- Gastric Cancer Management and Outcomes
- Sympathectomy and Hyperhidrosis Treatments
- Cancer Mechanisms and Therapy
- Acupuncture Treatment Research Studies
- Histone Deacetylase Inhibitors Research
- CAR-T cell therapy research
Cangzhou Central Hospital
2012-2022
Hebei Medical University
2012-2021
Tianjin Medical University
2019-2021
Jazz Pharmaceuticals (United States)
2020
Amgen (United States)
2015-2019
Academia Sinica
2008
Purpose: To evaluate the effect of esketamine combined with ultrasound-guided pectoral nerve block type II (Pecs block) on quality early postoperative recovery in patients undergoing a modified radical mastectomy (MRM) for breast cancer. Patients and Methods: A total 136 female an elective MRM unilateral cancer (UBC) first time were randomly divided into control group (group C, n=68) experimental (PE group, n=68). In sufentanil was used anesthesia induction patient-controlled intravenous...
7510 Background: CPX-351 (Vyxeos; daunorubicin and cytarabine liposome for injection), a dual-drug liposomal encapsulation of [C] [D], is approved by the FDA EMA treatment adults with newly diagnosed therapy-related AML or myelodysplasia-related changes. Primary analysis pivotal phase 3 study (NCT01696084) that formed basis these approvals evaluated patients (pts) aged 60-75 y high-risk/secondary found significantly improved median overall survival (OS) vs conventional 7+3, comparable safety...
A new technique for analgesia called pectoral nerve block is widely used in surgeries of breast cancer. Pectoral type II (Pecs II) has less influence on immunity when compared with general anesthesia method. The purpose this research to demonstrate whether Pecs the recurrence cancer after surgical operation.526 patients were recruited and randomized into group group. Recurrence-free survival (RFS), distant recurrence-free (DRFS), overall (OS) evaluated two groups.Based statistical data, only...
In this double-blind, randomized, multicenter study, 244 patients with at least moderate pain after major orthopaedic surgery received intramuscular Ketorolac (60 mg followed by 30 mg) or meperidine (100 placebo) every 2 to 6 hours as needed for many 5 days. Analgesic response was evaluated initial study drug administration and thereafter each night bedtime. Both active treatment groups had similar 3-hour summed intensity difference total relief scores the first dose that were superior...
The nuclear factor (NF)-κB and NOD-like receptor protein 3 (NLRP3) pathways promote inflammatory signaling that injures the kidneys, whereas erythroid 2-related 2 (Nrf2) pathway promotes anti-inflammatory inhibits oxidative damage. Penehyclidine hydrochloride (PHC) NF-κB activates Nrf2 signaling. We investigated whether PHC induces communication between NF-κB/NLRP3 pathways, thereby protecting against renal ischemia/reperfusion (rI/R)-induced lung inflammation. Rat alveolar macrophages...
Lipoxin A4 (LA4), a bioactive product of arachidonic acid, has been shown to exert strong anti-inflammatory activity. By contrast, the action LA4 in renal ischaemia-reperfusion (RIR)-mediated acute lung inflammation (ALI) model and potential pathogenesis condition is still unclear. The aim current research was investigate effect on RIR-induced ALI. rat ALI induced by RIR. injected via tail vein immediately after results indicate that markedly inhibits inflammatory cells infiltration,...
The objective of the present study was to investigate effects different anesthesia methods on postoperative transient neurologic syndrome (TNS) in patients with lumbar disc herniation (LDH). Ninety-six LDH were selected from November 2015 October 2016 Cangzhou Central hospital. All treated percutaneous transforaminal endoscopic discectomy. randomly divided into control group and observation group, 48 each. Combined spinal-epidural performed for while epidural applied group. levels T...
Introduction: Penehyclidine hydrochloride (PHC) is an anticholinergic with anti-inflammatory and anti-oxidation activities. PHC displayed protectivity against renal ischemia reperfusion (RIR) injury. Nevertheless, the precise of on RIR-induced lung injury remains unknown. Methods: We examined effects investigated underlying mechanism. induced RIR in mice administrated to mice. Kidney function was monitored by measuring blood urea nitrogen (BUN) creatinine level serum. evaluated injury,...