Chunhua Zhu

ORCID: 0000-0001-5299-9010
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About
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Research Areas
  • Drug-Induced Hepatotoxicity and Protection
  • Intensive Care Unit Cognitive Disorders
  • Liver Disease and Transplantation
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Nuts composition and effects
  • Liver Disease Diagnosis and Treatment
  • Cancer Mechanisms and Therapy
  • Respiratory Support and Mechanisms
  • Barrier Structure and Function Studies
  • Neurological Disease Mechanisms and Treatments
  • Nanoplatforms for cancer theranostics
  • Cancer-related molecular mechanisms research
  • Traumatic Brain Injury and Neurovascular Disturbances
  • Bioactive Compounds and Antitumor Agents
  • Spine and Intervertebral Disc Pathology
  • Anesthesia and Neurotoxicity Research
  • Anesthesia and Pain Management
  • Cancer, Stress, Anesthesia, and Immune Response
  • Drug Transport and Resistance Mechanisms
  • Spinal Hematomas and Complications
  • Pharmacological Effects of Natural Compounds
  • Plant and Fungal Interactions Research
  • Pharmacological Receptor Mechanisms and Effects

Cangzhou Central Hospital
2017-2021

Second Affiliated Hospital of Nanjing Medical University
2018-2019

Nanjing Medical University
2018

Wuxi Third People's Hospital
2017

Hebei Medical University
2012

Second Hospital of Hebei Medical University
2012

Gastric cancer (GC) is one of the most common tumors worldwide. Standard treatment after early detection involves surgical excision (recurrence possible), and metastatic gastric refractory to immuno-, radio-, harmful chemotherapies. Various natural compounds have shown efficacy in killing different cancers, albeit not always specifically. In this study, we show that dandelion root extract (DRE) specifically effectively suppresses proliferation migration human cells without inducing toxicity...

10.1016/j.biopha.2017.07.007 article EN cc-by-nc-nd Biomedicine & Pharmacotherapy 2017-07-15

Gastric cancer is one of the most prevalent malignancies and therapeutic strategies for patients with gastric remains limited. Local anesthetic levobupivacaine has demonstrated potential anti-cancer property, but its correlation ferroptosis poor understood. Here, we identified novel function in regulating cells. The treatment suppressed cell viabilities Edu-positive proportions. growth was reduced by vivo . Moreover, enhanced erastin-induced inhibitory impact on viabilities. levels Fe 2+...

10.3389/fphar.2021.681338 article EN cc-by Frontiers in Pharmacology 2021-06-09

In clinic, excessive acetaminophen (APAP) can cause kidney damage with uncertain mechanisms. Recently, accumulating evidence demonstrated a pathogenic role of mitochondrial dysfunction in the injury. Thus, this study, rotenone, complex I inhibitor, was applied to mice APAP-induced acute injury evaluate effect inhibition on APAP nephrotoxicity.After 3 days rotenone pretreatment, were administered (300mg/kg) by intraperitoneal injection for 24 h. Then injury, inflammation, and oxidative stress...

10.1159/000492589 article EN cc-by-nc-nd Kidney & Blood Pressure Research 2018-01-01

Mechanical ventilation (MV) can contribute to ventilator‑induced lung injury (VILI); dexmedetomidine (Dex) treatment attenuates MV‑related pulmonary inflammation, but the mechanisms remain unclear. Therefore, present study aimed explore protective effect and possible molecular of Dex in a VILI rodent model. Adult male Sprague‑Dawley rats were randomly assigned one seven groups (n=24 rats/group). Rats euthanized after 4 h continuous MV, pathological changes, wet/dry (W/D) weight ratio, levels...

10.3892/mmr.2020.11612 article EN cc-by-nc-nd Molecular Medicine Reports 2020-10-19

The objective of the present study was to investigate effects different anesthesia methods on postoperative transient neurologic syndrome (TNS) in patients with lumbar disc herniation (LDH). Ninety-six LDH were selected from November 2015 October 2016 Cangzhou Central hospital. All treated percutaneous transforaminal endoscopic discectomy. randomly divided into control group and observation group, 48 each. Combined spinal-epidural performed for while epidural applied group. levels T...

10.3892/etm.2017.4900 article EN Experimental and Therapeutic Medicine 2017-08-07
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