A5029581843- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Asthma and respiratory diseases
- Energy and Environment Impacts
- Pneumonia and Respiratory Infections
- Air Quality and Health Impacts
- Neonatal Respiratory Health Research
- Oral microbiology and periodontitis research
- Public Health and Nutrition
- Vitamin D Research Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Inflammatory Biomarkers in Disease Prognosis
- Nutrition and Health in Aging
- Pediatric health and respiratory diseases
- Tuberculosis Research and Epidemiology
- Intensive Care Unit Cognitive Disorders
- Climate Change and Health Impacts
- IL-33, ST2, and ILC Pathways
- Smoking Behavior and Cessation
- Cystic Fibrosis Research Advances
- Mycobacterium research and diagnosis
- Galectins and Cancer Biology
- Childhood Cancer Survivors' Quality of Life
- Health, psychology, and well-being
- Dental Research and COVID-19
JSS Medical College and Hospital
2014-2025
JSS Academy of Higher Education and Research
2014-2024
JSS Dental College and Hospital
2023
Institute of Medical Sciences
2018
Fortis Hospital
2018
Kempegowda Institute of Medical Sciences
2017
There is a need for biomarkers to predict outcomes, including mortality, in interstitial lung disease (ILD). Krebs von den Lungen-6 (KL-6) and surfactant protein D (SP-D) are associated with damage fibrosis all ILDs related important clinical outcomes. Though these two have been ILD there no studies that evaluated their predictive potential combination. This study aims determine whether KL-6 SP-D linked poor outcomes mortality. Additionally, we plan examine changes concentrations correspond...
Low Vitamin D levels have been associated with Chronic Obstructive Pulmonary Disease (COPD) and acute exacerbations.
Chronic obstructive pulmonary disease (COPD), the leading cause of mortality and morbidity worldwide, is characterized by abnormal activation inflammatory cells. The increased pro-inflammatory cytokines, such as tumour necrosis factor alpha (TNF-α) interleukin 1 beta (IL-1β), further amplify inflammation. We evaluated dose response relationship IL-1β TNF-α levels severity airflow limitation, differential responses in between biomass COPD (BMS-COPD) tobacco smoke (TS-COPD) using a case...
The prevalence of chronic obstructive pulmonary disease (COPD) is increasing in India and there a need to study the COPD, particularly rural areas, which may be most affected due their lifestyle.
Respiratory infections account for significant morbidity, mortality, and healthcare-related expenditure in patients admitted to the Intensive Care Unit (ICU).Respiratory 3.5 million deaths worldwide 79 loss of disability-adjusted life-years. [1]Antibiotics form main stay treatment various respiratory which are often initiated empirically based on their previous experiences, hence, leading inappropriate use antibiotics antimicrobial resistance. [2]Resistance has emerged recently due misuse is...
Introduction: Community-acquired pneumonia (CAP) is a common cause of morbidity and mortality in India. There need to understand the risk factors associated with severity CAP our population. This study was part international global initiative for methicillin-resistant Staphylococcus aureus (MRSA) evaluate MRSA. Methods: A total 100 consecutive cases admitted Department Pulmonary Medicine tertiary care hospital were recruited during March–July 2015. The assessed based on CURB-65 score....
Given the wide variations in prevalence of chronic obstructive pulmonary disease observed between populations with similar levels exposure to tobacco smoke, we aimed investigate possibility bronchitis (CB) two geographically distinct smoking rural Karnataka, India.The Burden Obstructive Lung Disease (BOLD) questionnaire was administered all men aged >30 years a cross-sectional survey. The χ(2) and Fisher's exact tests were used compare CB populations. Logistic regression analyse impact...
Between 2006 and 2010, in 16 randomly selected villages rural areas of Mysore district, south India, 8,457 subjects aged 30 above were screened for symptoms chronic respiratory disease. Of the subjects, 1,692 invited further evaluation lung function obstructive pulmonary disease (COPD) by spirometry, 1,085 these underwent assessments prevalent COPD its risk factors. These who then between 35 80 years, constituted Mysuru stUdies Determinants Health Rural Adults (MUDHRA) cohort. Among other...
(1) Introduction: COPD is a common and serious condition affecting significant proportion of the population globally. Patients often suffer from exacerbations which lead to worsening their health status respiratory function, can death. Quick cheap investigations are required that capable predicting mortality in patients with acute be applied low resource settings. (2) Materials methods: This was retrospective study carried out using hospital records admitted for AECOPD 1 January 2017 30...
Background and Objectives: Thin-section CT (TSCT) is currently the most sensitive imaging modality for detecting bronchiectasis. However, conventional TSCT or HRCT may overlook subtle lung involvement such as alveolar interstitial changes. Artificial Intelligence (AI)-based analysis offers potential to identify novel information on parenchymal that not easily detectable with traditional techniques. This study aimed assess in patients bronchiectasis using Bronchiectasis Radiologically Indexed...
Background Chronic obstructive pulmonary disease (COPD) is no longer considered a exclusive to the respiratory system. It multipronged with both lung and systemic involvement. Although forced expiratory volume (FEV) in one second of most commonly used markers assess severity, recent years, biomarkers such as interleukin-1 beta, serum C-X-C motif chemokine ligand 10, fibrinogen, soluble receptor for advanced glycation, surfactant protein D, club cell secretory have been proven be effective...
Background . Chronic obstructive pulmonary disease (COPD) is a devastating condition with limited pharmacotherapeutic options and exceptionally high public-health burden globally as well in India. Tobacco smoking the primary cause for COPD among men Systemic inflammation involving altered regulation of cytokines controlling host defense mechanism hallmark pathogenesis. However, biomarker discovery studies are Indian patients. Methods We assessed serum concentrations [median (25th-75th...
Rationale . Exposure to biomass smoke ( BMS ) has been implicated in chronic obstructive pulmonary disease COPD ). About 3 billion people worldwide use fuel for cooking and heating. Women rural communities of low- lower-middle-income countries are disproportionately exposed massive amounts during active hours (4–6 h/day). Therefore, exposure is considered as a risk factor the same order magnitude tobacco smoke. In India, due cultural reasons, women primary cook family mostly nonsmokers....
Aims At a tissue level, matrix metalloproteinase-1 (MMP-1) and transforming growth factor-beta 1 (TGF-β1) contribute to allergic airway inflammation, remodelling disease severity in asthma via different pathways. Their peripheral blood levels role diagnosis therapeutic monitoring has not been adequately explored. We investigated the association between MMP-1 TGF-β moderate severe persistent evaluated their performance characteristics by constructing receiver operating characteristic curves....
<b>Introduction:</b> Matrixmetalloproteinase-2(MMP-2) and Tissue inhibitor of Metalloproteinase-1(TIMP-1) are associated with airway inflammation remodelling in asthma. Studying their role may open avenues for newer therapeutic options. <b>Objective:</b> To evaluate whether MMP-2, TIMP-1 levels MMP-2/TIMP-1 ratio can be a biomarker asthma severity (GINA). <b>Methodology:</b> The MMP-2 were compared between moderate persistent (n=25), severe (n=25) normal controls (n=25). measured by ELISA to...
Objective: This study investigated the relationship between chronic obstructive pulmonary disease (COPD) and periodontitis, focusing on how periodontal health impacts COPD airflow limitation, exacerbations, hospitalization. Background: Periodontitis, a multifactorial inflammatory disease, is characterized by destruction of tooth-supporting structures, while global disorder with high mortality. Methods: A total 199 patients aged over 40 years underwent lung function tests (spirometry), 6 min...
Secretoglobin family 1A member 1 (SCGB1A1) alternatively known as club cell protein 16 is a protective pneumo-protein. Decreased serum levels of SCGB1A1 have been associated with tobacco smoke induced chronic obstructive pulmonary disease (TS-COPD). Exposure to biomass (BMS) an important COPD risk factor among women in low and lower-middle income countries. Therefore, cross-sectional study (n = 50/group; total 200 subjects) we assessed BMS-COPD subjects (11 male, 39 female) compared TS-COPD...
: Pulmonary tuberculosis (TB) remains a major public health issue in India, with high incidence and mortality. The current literature on post-TB sequelae functional defects focuses heavily spirometry, conflicting obstruction vs. restriction data, lacks advanced statistical analysis, has insufficient data diffusion limitation impairment.