ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThermal and Light Control of the Sol-Gel Phase Transition in Cholesterol-Based Organic Gels. Novel Helical Aggregation Modes As Detected by Circular Dichroism Electron Microscopic ObservationKazutaka Murata, Masayoshi Aoki, Tsuyoshi Suzuki, Takaaki Harada, Hirosuke Kawabata, Takashi Komori, Fumio Ohseto, Keiko Ueda, Seiji ShinkaiCite this: J. Am. Chem. Soc. 1994, 116, 15, 6664–6676Publication Date (Print):July 1, 1994Publication History Published...

A mild, general, and functional group tolerant intramolecular hydroalkoxylation hydroacyloxylation of unactivated olefins using a Co(salen) complex, an N-fluoropyridinium salt, disiloxane reagent is described. This reaction was carried out at room temperature afforded five- six-membered oxygen heterocyclic compounds, such as cyclic ethers lactones. The Co complex optimized for previously rare medium ring formation by hydrofunctionalization olefins. powerful catalyst system also enables the...

Abstract The gram-order of fullerene (C60) with 99.8 wt% purity was isolated from carbon soot by fractional precipitation 5,11,17,23,29,35,41,47-octa-tert-butylcalix[8]arene-49,50,51,52,53,54,55,56-octol. This is a very convenient and efficient C60 purification method without any precious apparatus.

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and characterization of novel p-terphenoquinone analogs involving a central dihydrothiophenediylidene structureKazuko Takahashi, Tsuyoshi Suzuki, Kimio Akiyama, Yusaku Ikegami, Yoshimasa FukazawaCite this: J. Am. Chem. Soc. 1991, 113, 12, 4576–4583Publication Date (Print):June 1, 1991Publication History Published online1 May 2002Published inissue 1 June...

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTp-Diphenoquinone analogs extended by dihydrothiophenediylidene insertion. A novel amphoteric multistage redox systemKazuko Takahashi and Tsuyoshi SuzukiCite this: J. Am. Chem. Soc. 1989, 111, 14, 5483–5485Publication Date (Print):July 1, 1989Publication History Published online1 May 2002Published inissue 1 July 1989https://pubs.acs.org/doi/10.1021/ja00196a075https://doi.org/10.1021/ja00196a075research-articleACS PublicationsRequest reuse...

Abstract Background Activation of melanocortin 1 receptor (MC1R) is known to exert broad anti-inflammatory and anti-fibrotic effects. The purpose this study investigate the potential dersimelagon, a novel oral MC1R agonist, as therapeutic agent for systemic sclerosis (SSc). Methods effects dersimelagon phosphoric acid (MT-7117) on skin fibrosis lung inflammation were evaluated in bleomycin (BLM)-induced SSc murine models that optimized prophylactic evaluation. Microarray-based gene...

The activation of melanocortin 1 receptor (MC1R) on melanocytes stimulates the production eumelanin. A tridecapeptide α melanocyte-stimulating hormone (αMSH) is known to induce skin pigmentation.We characterised properties a novel oral MC1R agonist dersimelagon (MT-7117) with respect its specific binding MC1R, downstream signalling and eumelanin in experimental models.The competitive intracellular cyclic adenosine 3', 5'-monophosphate cells expressing recombinant receptors were examined....

Epidermal growth factor receptor (EGFR) and ErbB2 are currently recognized as validated target molecules in cancer treatment strategies. MP-412 (AV-412) is a potent dual inhibitor of EGFR tyrosine kinases, including the mutant EGFR(L858R,T790M), which clinically resistant to EGFR-specific kinase inhibitors erlotinib gefitinib. In an enzyme assay, inhibited variants nanomolar range with over 100-fold selectivity compared other apart from abl flt-1, were both moderately sensitive compound....

This study evaluated the feasibility and safety of transjugular intrahepatic portosystemic shunt (TIPS) procedure using hepatic artery-targeting guidewire technique for puncture step.We retrospectively reviewed 11 consecutive patients (5 men 6 women, aged 46-76 years (mean 64 years)) with portal hypertension in whom TIPS was performed. As first step all cases, a micro-guidewire inserted into arterial branch accompanying venous through microcatheter coaxially advanced from 5-French catheter...

Development and endocrine changes in Thoroughbreds colts fillies were compared between those reared at two facilities of the Japan Racing Association, Hidaka Training Research Center (Hidaka) Miyazaki Yearling Farm (Miyazaki). Thoroughbred born 2003 2010 used. Each colt group filly was divided into 2 groups, respectively, raised or for 7 months from September 1 year old to April years old. For growth parameters, body weight, height withers, girth cannon circumferences measured once a month....

Abstract Background We report a case of anaphylaxis induced by natto (fermented soybeans) allergy that occurred following dermal sensitization from jellyfish sting. Case presentation A 49-year-old male presented to the emergency room complaining an acute onset erythema with pruritis appeared while he was surfing. Given his heart rate dropped ~ 40 bpm without decline in blood pressure or oxygen saturation, we suspected and administered 0.5 mg adrenaline intramuscularly. Immediately after...

We report the results of Raman, infrared, and inelastic neutron scattering investigations vibrational spectrum complex p-tert-butylcalix[8]arene(1:1)fullerene, a system with almost isolated ${\mathrm{C}}_{60}$ molecules confined inside neutral cages. All internal optical-active modes guest have been identified, further which can be attributed to intramolecular vibrations appear in function. A comparison empty p-tert-butylcalix[8]arene indicates that host-guest interaction is very weak. As...

Although epidermal growth factor receptor (EGFR) kinase inhibitors are effective for the treatment of non-small cell lung cancer (NSCLC), emergence mutations resistant to these inhibitors, such as T790M, has become a clinical problem. Recently, ErbB2 have also been identified in small number NSCLC patients. Therefore, novel therapies overcome desirable. We describe antitumor activity MP-412 (AV-412), dual EGFR/ErbB2 inhibitor, against three models with EGFR and various human xenografts...

M. Takeshita, T. Suzuki and S. Shinkai, J. Chem. Soc., Commun., 1994, 2587 DOI: 10.1039/C39940002587

One- to two-year-old Thoroughbred colts and fillies being reared in Miyazaki (warm climate) Hidaka (cold climate), Japan, were administered extended photoperiod (EP) treatment between December 20 the following April 10, its effect on growth, endocrine changes, gonadal activation, hair coat condition was investigated. In Miyazaki, no of EP noted growth indices, including body weight (BW), height at withers (HW), girth, cannon circumference (CC), whereas BWs CCs significantly higher group than...

ErbB2 has been proven to be an important target for breast cancer therapy. MP-412 is a dual and epidermal growth factor receptor tyrosine kinase inhibitor belonging irreversible-type anilinoquinazoline derivative. We demonstrate herein that along with the inhibition, ability induce ubiquitination, internalization, degradation of in several human cell lines at concentrations relatively higher than those required inhibition. Another irreversible inhibitor, CI-1033, showed similar activity,...

Abstract A revised structure for trichodermatide A, which is a C10 epimer of the originally reported structure, proposed. The revision supported by X‐ray synthetic intermediate synthesized according to our previous route A. stereochemistry was also NOESY experiment. Finally, we Trauner's compound corresponding from through Mitsunobu reaction at C10.

The present study conducted a statistical survey of 1118 patients with jaw deformity who underwent surgical orthodontic treatment in the Section Maxillofacial Orthognathics, Department Orthodontics, Tokyo Medical and Dental University from 1980 to 2009.The results were as follows:1. There 442 male 676 female (ratio 1:1.5).2. mean age at operation all was 24.2 years old. has tended increase recent years.3. most common condition mandibular prognathism without other deformities jaw, accounting...