Fruit ripening in response to treatments with propylene, 1-methycyclopropene (1-MCP), and low temperature was characterized 'Sanuki Gold' kiwifruit, Actinidia chinensis Planch. Propylene treatment immediately induced rapid fruit softening, increased AC-PG (polygalacturonase) AC-EXP (expansin) mRNA accumulation, stimulated an increase the soluble solid concentration (SSC) a decrease titratable acidity (TA). After 3 d exposure ethylene production AC-PL (pectate lyase) accumulation were...

Background: Transient bacteremia frequently occur secondary to several periodontal procedures. The purpose of the present study is investigate effects irrigation with an essential oil–containing antiseptic (EO) and oral administration azithromycin (AZM) on caused by scaling root planing (SRP). Methods: Thirty patients chronic periodontitis were randomly assigned three groups (control, EO, AZM). EO group received quadrant subgingival mouthrinsing was continued at home for 1 week. Oral AZM...

Abe D, Kubota T, Morozumi Shimizu Nakasone N, Itagaki M, Yoshie H. Altered gene expression in leukocyte transendothelial migration and cell communication pathways periodontitis-affected gingival tissues. J Periodont Res 2011; 46: 345–353. © 2011 John Wiley & Sons A/S Background Objective: Gene is related to the pathogenesis of periodontitis plays a crucial role local tissue destruction disease susceptibility. The aims present study were identify specific genes biological using microarray...

Abstract The stereochemistry in the conversion of (E)-α,β-unsaturated esters into corresponding β,γ-unsaturated esters, and that aldehydes silyl enol ethers, were investigated. Z/E ratios resulting ethers varied according to γ-substituents α-substituents aldehydes, respectively. This phenomenon was rationalized by a “syn-effect”, which may be attributed primarily σ → π* interaction and/or 6π-electron homoaromaticity.

Our previous study revealed that human CYP24A1 catalyzes a remarkable metabolism consisting of both C-23 and C-24 hydroxylation pathways used 25(OH)D(3) 1alpha,25(OH)(2)D(3) as substrates, while rat showed extreme predominance the over pathway [Sakaki, T., Sawada, N., Komai, K., Shiozawa, S., Yamada, Yamamoto, Ohyama, Y. Inouye, K. (2000) Eur. J. Biochem. 267, 6158-6165]. In this study, by using Escherichia coli expression system for CYP24A1, we identified 25,26,27-trinor-23-ene-D(3)...

Epidermal growth factor receptor (EGFR) and ErbB2 are currently recognized as validated target molecules in cancer treatment strategies. MP-412 (AV-412) is a potent dual inhibitor of EGFR tyrosine kinases, including the mutant EGFR(L858R,T790M), which clinically resistant to EGFR-specific kinase inhibitors erlotinib gefitinib. In an enzyme assay, inhibited variants nanomolar range with over 100-fold selectivity compared other apart from abl flt-1, were both moderately sensitive compound....

Microbioreactors are effective for high-throughput production of expensive products from small amounts substrates. Lipases versatile enzymes chiral syntheses, and highly activated when immobilized in alkyl-substituted silicates by the sol-gel method. For practical application lipases to a flow system, microbioreactor loaded with macroporous silica monolith is well suited, because it can be easily integrated chromatographic separator optical resolution. We attempted develop containing...

ABSTRACT The concentrations of the bioactive components, acteoside, aucubin and catalpol, production yield, crude protein (CP) ash contents in 25 ecotypes (Et) plantain (PL, Plantago lanceolata L.), found northern Japan, commercial cultivars, Grasslands Lancelot (GL) Ceres Tonic (CT), were investigated. quantitative determination components was performed by high performance liquid chromatography. acteoside content some Et significantly higher ( P < 0.05) than CT numerically GL other Et....

Thirty chronic periodontitis patients were randomly assigned to 3 groups: control, saline, and essential oil-containing antiseptic (EO). Subgingival plaque was collected from a total of 90 pockets across all subjects. Subsequently, subgingival ultrasonic instrumentation (SUI) performed by using EO or saline as the irrigation agent. After continuous mouth rinsing at home with for 7 days, plaques sampled again. Periodontopathic bacteria quantified modified Invader PLUS assay. The bacterial...

Recent studies have shown the contribution of genetic determinants to athletes' physical ability. However, despite fact that cognitive abilities like self-control and stress-tolerance influence competitive performance, few date investigated association between polymorphism, which is linked ability athletic performance. The present study link single-nucleotide polymorphisms (SNPs), are known exert influences on dopaminergic neural function performance swimmers. results revealed superior in...

Abstract The stereochemistry in the conversion of (E)-α,β-unsaturated esters to corresponding β,γ-unsaturated by treatment with lithium hexamethyldisilazide presence HMPA was investigated. Z/E ratios resulting varied according γ-substituents esters. This phenomenon rationalized “syn-effect” which may be attributed primarily σ→π* interaction and/or 6π-electron homoaromaticity.

Recently, we demonstrated that some A-ring-modified vitamin D₃ analogs had unique biological activity. Of these analogs, 2α-propoxy-1α,25(OH)₂D₃ (C3O1) and 2α-(3-hydroxypropoxy)-1α,25(OH)₂D₃ (O2C3) were examined for metabolism by CYP27A1 CYP24A1. Surprisingly, catalyzed the conversion from C3O1 to O2C3, which has 3 times more affinity D receptor than C3O1. Thus, O2C3 is considered be a metabolic activation process. Five metabolites...

Abstract Toward the elucidation of origin “syn-effect,” stereochemistry isomerization (E)-α-fluorovinylic sulfones to corresponding allylic under mild basic conditions was investigated. The ratio (Z)-isomers resulting decreased in following order for γ-substituents starting vinylic sulfones: F- > EtO- CH3- BnS- CH3CH2- (CH3)2CH- (CH3)3C-, C6H5-. fluorine atom showed highest which is herein defined as an effect that stabilizes syn-conformation transition state against a steric or...

Background: The aims of the present study were: [1] to evaluate whether Erbium-Doped: Yttrium, Aluminum and Garnet (Er: YAG) laser could be a prophylactic methods against transient bacteremia during scaling root planing (SRP) [2] confirm efficacies SRP with Er: YAG by clinical microbiologic evaluations. Methods: Twenty chronic periodontitis subjects were randomly treated for quadrant either conventional hand instrument (n=10) or monotherapy. Peripheral blood samples drawn at baseline 6...

Bernard–Soulier syndrome (BSS) is a rare bleeding disorder of autosomal recessive inheritance characterized by macrothrombocytopenia. We report the case 14-year-old girl diagnosed with BSS who fourth-generation Brazilian Japanese descent and has compound heterozygote mutation as responsible gene. The heterozygosity would have occurred from global long-term racial migration that brought about an accidental encounter two mutant alleles different origins.

Severe cases of genu varum represent a major challenge in obtaining normal configuration the proximal tibia and overall limb alignment.We performed inverted V-shaped high tibial osteotomy (HTO) by using locking plate for recurrent severe bilateral vara 15-year-old female patient with Turner syndrome. Preoperative medial angle (MPTA) standing femorotibial (FTA) right/left legs were 67°/69° 197°/203°, respectively. In order to obtain neutral alignment, correction knees was required be 23°/32°....