A5018761422- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Bone Tissue Engineering Materials
- Urological Disorders and Treatments
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- Mechanical Circulatory Support Devices
- Antimicrobial Peptides and Activities
- Protein Hydrolysis and Bioactive Peptides
- Central Venous Catheters and Hemodialysis
- Peptidase Inhibition and Analysis
- Congenital Heart Disease Studies
- Polymer Surface Interaction Studies
- Orthopaedic implants and arthroplasty
- Cardiovascular Function and Risk Factors
- Bladder and Urothelial Cancer Treatments
- Dialysis and Renal Disease Management
- Pelvic floor disorders treatments
- biodegradable polymer synthesis and properties
- Additive Manufacturing and 3D Printing Technologies
- Elasticity and Material Modeling
- Esophageal and GI Pathology
- Anorectal Disease Treatments and Outcomes
- Urinary Tract Infections Management
- Dental Implant Techniques and Outcomes
University of Padua
2020-2025
Consorzio per la Ricerca Sanitaria
2020-2024
International Renal Research Institute of Vicenza
2018
The history of biomaterials dates back to the mists time: human beings had always used exogenous materials facilitate wound healing and try restore damaged tissues organs. Nowadays, a wide variety are commercially available many others under investigation both maintain bodily functions. Emerging clinical needs forced development new biomaterials, lately discovered allowed for performing applications. definition as specifically conceived biomedical uses was raised when it acknowledged that...
Bladder cancer (BC) is among the most common malignancies in world and a relevant cause of mortality. BC one frequent causes for bladder removal through radical cystectomy, gold-standard treatment localized muscle-invasive some cases high-risk, non-muscle-invasive cancer. In order to restore urinary functionality, an autologous intestinal segment has be used create diversion. However, several complications are associated with bowel-tract removal, affecting patients’ quality life. The present...
Hybrid biomaterials allow for the improvement of biological properties materials and have been successfully used implantology in medical applications. The covalent selective functionalization with bioactive peptides provides favorable results tissue engineering by supporting cell attachment to biomaterial through biochemical cues interaction membrane receptors. Since may alter chemical physical biomaterials, this study we characterized responses differently functionalized chitosan analogs....
Background: Nowadays, a challenging task concerns the biomechanical study of human lower urinary tract (LUT) due to variety its tissues and low availability samples. Methods: This work attempted further extend knowledge through comprehensive mechanical characterization male LUT by considering numerous harvested from same cadaver, including some never studied before. Samples bladder, urethra, prostate, Buck’s fascia tunica albuginea related corpora cavernosa were considered distinguished...
Background: Microtia is a congenital outer ear deformity that causes the auricle to be absent or underdeveloped. It frequently associated with external auditory canal atresia and hearing psychosocial problems. Objectives: We thoroughly investigate aspects of microtia explore both current innovative therapies. Methods: A systematic literature review was conducted following PRISMA guidelines, focusing on reconstruction methodologies. This utilized three databases: PubMed, Scopus, Web Science....
<b><i>Background:</i></b> Inadequate removal of molecules between 5 and 50 KDa may cause long-term complication in chronic hemodialysis. Medium cut-off (MCO) is a new class membranes with enhanced sieving properties negligible albumin loss. MCO membrane makes it possible to perform expanded hemodialysis (HDx), technique based on high internal filtration (IF).The present study designed quantify IF 2 dialyzers (Theranova 400 500, Baxter, Deerfield, USA) using nuclear...
Abstract Background Due to the shortage of organs’ donors that limits biological heart transplantations, mechanical circulatory supports can be implanted in case refractory end-stage failure replace partially (Ventricular Assist Device, VAD) or completely (Total Artificial Heart, TAH) cardiac function. The hemocompatibility is a fundamental issue has not yet been fully matched; it mostly depends on nature blood-contacting surfaces. Methods In order obtain hemocompatible materials, pool...
Esophageal reconstruction through bio-engineered allografts that highly resemble the peculiar properties of tissue extracellular matrix (ECM) is a prospective strategy to overcome limitations current surgical approaches. In this work, human esophagus was decellularized for first time in literature by comparing three detergent-enzymatic protocols. After decellularization, residual DNA quantification and histological analyses showed all protocols efficiently removed cells, (<50 ng/mg...
Structural cardiac lesions are often surgically repaired using prosthetic patches, which can be biological or synthetic. In the current clinical scenario, patches derived from decellularization of a xenogeneic scaffold gaining more interest as they maintain natural architecture extracellular matrix (ECM) after removal native cells and remnants. Once implanted in host, these induce tissue regeneration repair, encouraging angiogenesis, migration, proliferation, host cell differentiation....
Human and animal pericardia are among the most widely exploited materials suitable to repair damaged tissues in cardiovascular surgery context. Autologous, xenogeneic (chemically treated) homologous largely utilized, but they do exhibit some crucial drawbacks. Any tissue treated with glutaraldehyde is known be prone calcification vivo, lacks regeneration potential, has limited durability, can result cytotoxicity. Moreover, autologous have availability. Decellularized biological represent a...
The main purpose of tissue engineering is to fabricate and exploit engineered constructs suitable for the effective replacement damaged tissues organs, able perfectly integrate with host’s organism without eliciting any adverse reaction. Ideally, autologous materials represent best option, but they are often limited due low availability compatible healthy tissues. So far, one therapeutic approach relies on exploitation synthetic materials: exhibit good features in terms impermeability,...
The main purpose of tissue engineering is to fabricate and exploit engineered constructs suitable for the effective replacement damaged tissues organs perfectly integrate with host’s organism without eliciting any adverse reaction. Ideally, autologous materials represent best option, but they are often limited due low availability compatible healthy tissues. So far, one therapeutic approach relies on exploitation synthetic as exhibit good features in terms impermeability, deformability,...
Introduction: Clinics increasingly require readily deployable tubular substitutes to restore the functionality of structures like ureters and blood vessels. Despite extensive exploration various materials, both synthetic biological, optimal solution remains elusive. Drawing on abundant literature experiences, there is a pressing demand for substitute that not only emulates native tissue by providing requisite signals growth factors but also exhibits appropriate mechanical resilience...
The most common aortic valve diseases in adults are stenosis due to calcification and regurgitation. In pediatric patients, pathologies less common. When a native is surgically replaced by prosthetic one, it necessary consider that the latter has limited durability. particular, current bioprosthetic valves have be after approximately 10 years; mechanical prostheses more durable but require administration of permanent anticoagulant therapy. With regard both biological their inability follow...
Among the urinary tract's malignancies, bladder cancer is most frequent one: it at tenth position of common cancers worldwide. Currently, gold standard therapy consists radical cystectomy, which results in need to create a diversion using bowel segment from patient. Nevertheless, due several complications associated with resection and anastomosis, significantly affect patient quality life, becoming extremely important find an alternative solution. In our recent work, we proposed...
The covalent functionalization of synthetic peptides allows the modification different biomaterials (metallic, polymeric, and ceramic), which are enriched with biologically active sequences to guide cell behavior. Recently, this strategy has also been applied decellularized biological matrices. In study, anchorage a peptide (REDV) pericardial matrix via Schiff base is realized starting from concentrated solutions (10-4 M 10-3 M). use labeled demonstrated that as concentration working...
Over the years, several devices have been created (and development of many others is currently in progress) to be permanent contact with blood: mechanical circulatory supports represent an example thereof. The hemocompatibility these largely depends on chemical composition blood-contacting components. In present work, innovative material (hybrid membrane) proposed fabricate inner surfaces a pulsatile ventricular chamber: it has obtained by coupling synthetic polymer (e.g., commercial...
The production of biomedical devices able to appropriately interact with the biological environment is still a great challenge. Synthetic materials are often employed, but they fail replicate and functional properties native tissues, leading variety adverse effects. Several commercial products based on chemically treated xenogeneic tissues: their principal drawback due weak mechanical stability low durability. Recently, decellularization has been proposed bypass drawbacks both synthetic...
Abstract Population aging, reduced economic capacity, and neglecting the treatments for oral pathologies, are main causal factors about 3 billion individuals who suffering from partial/total edentulism or alveolar bone resorption: thus, demand dental implants is increasingly growing. To achieve a good prognosis implant‐supported restorations, adequate peri‐implant volume mandatory. The Guided Bone Regeneration (GBR) technique one of most applied methods reconstruction treatment deficiencies....
Conduit substitutes are increasingly in demand for cardiovascular and urological applications. In cases of bladder cancer, radical cystectomy is the preferred technique: after removing bladder, a urinary diversion has to be created using autologous bowel, but several complications associated with intestinal resection. Thus, alternative required avoid use, preventing facilitating surgical procedures. present paper, we proposing exploitation decellularized porcine descending aorta as novel...
Right ventricle outflow tract obstruction (RVOTO) is a congenital pathological condition that contributes to about 15% of heart diseases. In most cases, the replacement right in pediatric age requires subsequent pulmonary valve adulthood. The aim this study was investigate extracellular matrix scaffold obtained by decellularization porcine using new detergent (Tergitol) instead Triton X-100. decellularized evaluated for integrity its (ECM) structure testing biochemical and mechanical...
Urinary incontinence is still an underestimated problem due to its anatomical complexity and social taboo. Most of the time, it believed affect predominantly elderly female population, literature lacks data on presence in younger male populations. Its relationship with other pelvic floor dysfunctions (PFDs) sport activity remains open topic. Thus, present study surveyed 342 subjects both genders, ranging from 18 39 y/o different levels, understand prevalence PFDs (such as haemorrhoids, anal...
Current surgical options for patients requiring esophageal replacement suffer from several limitations and do not assure a satisfactory quality of life. Tissue engineering techniques the creation customized "self-developing" substitutes, which are obtained by seeding autologous cells on artificial or natural scaffolds, allow simplifying procedures achieving good clinical outcomes. In this context, an appealing approach is based exploitation decellularized tissues as biological matrices to be...