A5102005297- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- CRISPR and Genetic Engineering
- Immune cells in cancer
- Reproductive System and Pregnancy
- Lung Cancer Research Studies
- Cancer Genomics and Diagnostics
- RNA Research and Splicing
- Ear and Head Tumors
- Calcium signaling and nucleotide metabolism
Central South University
2015-2024
Third Xiangya Hospital
2015-2024
Abstract Despite receiving first-line treatment, ovarian cancer patients continue to experience a high rate of recurrence; nearly all women with develop chemoresistance and succumb the disease. In this study, cancer-associated fibroblasts (CAFs) normal (NFs) were isolated from tumor-containing omenta, respectively, downregulation osteoglycin (OGN) in CAFs was observed. OGN overexpression significantly inhibited cell viability, DNA synthesis, invasion. also changed epithelial-mesenchymal...
Abstract Cisplatin (DDP)‐based chemotherapy is a standard strategy for ovarian cancer (OC), while chemoresistance remains major therapeutic challenge. Transcription factor SOX9 has been reported to be associated with tumor cell proliferation, metastasis, and chemoresistance. In the current study, we observed higher expression in OC lines; overexpression might aggravate of DDP, whereas its knockdown enhanced We screened candidate microRNAs (miRNAs) which target using online tools further...
Cancer stem cells (CSCs) are thought to be responsible for cancer progression and therapeutic resistance but identification of this subpopulation requires selective markers. Fortunately, side population (SP) analysis brings a novel method CSCs study. In study, we identified SP cells, which demonstrated rich in CSCs, four nasopharyngeal carcinoma (NPC) cell lines. We investigated from HK‐1 NPC line showed characteristics subpopulation. displayed greater proliferation invasion expressed high...
Recent studies have reported that T-cell differentiation protein 2 (MAL2) is an important regulator in cancers. Here, we downloaded data from multiple databases to analyze MAL2 expression and function pan-cancers, especially ovarian cancer (OC). Gene Expression Profiling Interactive Analysis (GEPIA) was used examine 13 types of cancer. Kaplan-Meier plotter database the overall survival rate pan-cancers. The Catalog Somatic Mutations Cancer (COSMIC), cBioPortal, UCSC were mutation human...
Background: Emerging proof suggests that microRNA (miRNA) malfunction is correlated to the generation and development of multiple malignancies. It has been proven miRNA (miR)-139 represses a variety However, understanding its impact on ovarian cancer (OC) insufficient. We aimed investigate expression function miR-139 in OC. Methods: The mir-139 was detected recorded, relationship remaining OC cells explored. At same time, we studied correlation between ATP7A by luciferase reporter test,...