Junyu He

ORCID: 0000-0001-6969-8580
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About
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Research Areas
  • Perovskite Materials and Applications
  • Calcium signaling and nucleotide metabolism
  • Cancer, Hypoxia, and Metabolism
  • Solid-state spectroscopy and crystallography
  • Wheat and Barley Genetics and Pathology
  • Ubiquitin and proteasome pathways
  • Genetic Mapping and Diversity in Plants and Animals
  • Endoplasmic Reticulum Stress and Disease
  • Adenosine and Purinergic Signaling
  • RNA Research and Splicing
  • Cancer-related gene regulation
  • Immune Cell Function and Interaction
  • 14-3-3 protein interactions
  • Natural product bioactivities and synthesis
  • Plant Disease Resistance and Genetics
  • Heat shock proteins research
  • RNA modifications and cancer
  • Genomics, phytochemicals, and oxidative stress
  • TGF-β signaling in diseases
  • Optical properties and cooling technologies in crystalline materials
  • Cancer Mechanisms and Therapy
  • Optical and Acousto-Optic Technologies
  • Carbohydrate Chemistry and Synthesis
  • Silkworms and Sericulture Research
  • Melanoma and MAPK Pathways

Hunan University
2013-2025

Kunming Institute of Botany
2025

Second People Hospital of Hunan
2016-2025

China Three Gorges University
2022-2024

Hunan Cancer Hospital
2015-2023

Central South University
2014-2023

Yunnan Agricultural University
2020-2023

Hunan Institute of Mental Health
2018

Institute of Molecular Biology, Academia Sinica
2018

Xiangya Hospital Central South University
2017

Analyses of the 5' regulatory sequences genes encoding barbiturate-inducible cytochromes P450BM-1 and P450BM-3 from Bacillus megaterium for P450b P450e rat revealed a string 17 base pairs in each that shared high degree sequence identity. Labeled oligonucleotide probes these four were tested gel retardation assays with protein obtained B. grown either presence or absence barbiturates nuclear extracts livers rats left untreated injected phenobarbital. Each 17-mers bound strongly to single...

10.1016/s0021-9258(20)89529-5 article EN cc-by Journal of Biological Chemistry 1991-04-01

Abstract Tin‐based halide perovskites (ASnX 3 ) have garnered substantial interest due to their unique photoelectric properties and environmentally friendly features. The A‐site ions tuning strategy has been proven promote material performance. However, there is a lack of systematic research on the optical properties, lattice structure variation, band evolution in tin‐based when tune from organic inorganic. Herein, MA 1−x Cs x SnBr SnI (0≤x≤1) flakes are synthesized through one‐pot reaction...

10.1002/smll.202409546 article EN Small 2025-01-19

Abstract Metal halide perovskites have attracted much attention due to their properties and wide applications in optoelectronic devices. B‐site ion substitution, especially heterovalency is proven be one of the practical approaches modulate lattice structure improve physicochemical properties. Here, bandgap modulation all‐inorganic CsPbX 3 are achieved by substituting Pb 2+ with Bi 3+ . A series CsPb 1‐ x Br (0 ≤ 1) microplates values precisely tuned prepared a chemical vapor deposition...

10.1002/adom.202403202 article EN Advanced Optical Materials 2025-02-17

Inhibin B (INHBB), a heterodimer of common α‐subunit and βB‐subunit, is glycoprotein belonging to the transforming growth factor‐β (TGF‐β) family. In this study, we observed INHBB expression was reduced in nasopharyngeal carcinoma (NPC) tissues compared non‐tumor epithelium tissues, associated with lymph node metastasis, stage disease, clinical progress. Positive NPC predicted better prognosis (overall survival, P = 0.038). However, molecular mechanisms have not been addressed NPC. We...

10.1111/cas.13780 article EN cc-by-nc-nd Cancer Science 2018-08-29

Cervical cancer is one of the most common malignant tumors in women all over world. The exact mechanism occurrence and development cervical has not been fully elucidated. CD38 a type II transmembrane glycoprotein, which was found to mediate diverse activities, including signal transduction, cell adhesion, cyclic ADP-ribose synthesis. Here, we reported that promoted proliferation inhibited apoptosis cells by affecting mitochondria functions. We established stable lines with over-expressed....

10.1002/mc.22677 article EN Molecular Carcinogenesis 2017-05-24

Fos-related antigen 1 (Fra-1) is a nuclear transcription factor that regulates cell growth, differentiation, and apoptosis. It involved in the proliferation, invasion, apoptosis epithelial mesenchymal transformation of malignant tumor cells. Fra-1 highly expressed gastric cancer (GC), affects cycle distribution GC cells, participates occurrence development. However, detailed mechanism unclear, such as identification Fra-1-interacting proteins their role pathogenesis. In this study, we...

10.32604/or.2023.029698 article EN cc-by Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics 2023-01-01

There are different views of how the immune system participates in reaction to cancer. Here, we evaluated expression DAMP proteins HSP70 and cancer-testis antigen SPAG9 patients with hepatocellular carcinoma (HCC) lung cancer explore tumor immunity. Our analysis showed that levels antibody were significantly higher serum HCC than healthy subjects (P < 0.001), but there no differences controls. Levels newly diagnosed treated 0.05), or antibody. antibody, not also hepatitis/cirrhosis = 0.005,...

10.1007/s12192-016-0758-5 article EN cc-by-nc-nd Cell Stress and Chaperones 2016-12-27

Increasing evidence has suggested that certain types of cancer possess their own stem-like cells, and one subset these termed the side population (SP), may have an important role in tumorigenesis therapy. However, molecular mechanisms underlying modulation SP cells nasopharyngeal carcinoma (NPC) remained elusive. In present study, it was hypothesized dysregulation phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/Akt signaling pathway influence non-SP (NSP) phenotype. from HK-1 NPC cell...

10.3892/ol.2015.3218 article EN Oncology Letters 2015-05-18

Danger-associated molecular patterns (DAMPs) are activated by endogenous signals that originate from stressed, injured, or necrotic cells, signifying "danger" to the host. In this study, we evaluated expression of DAMP heat shock protein 70 (HSP70) in trauma patients with and without secondary infections. Levels glucose (GLU), procalcitonin (PCT), total cholesterol (T-Chol), white blood cell (WBC) counts were also at three time stages after trauma. Our analysis showed levels serum HSP70...

10.1007/s12192-016-0694-4 article EN cc-by-nc-nd Cell Stress and Chaperones 2016-05-02

In contrast to normal cells, cancer cells typically undergo metabolic reprogramming. Studies have shown that oncogenes play an important role in this CD38 is a multifunctional transmembrane protein expressed abnormally variety of tumor types. To investigate the effect and possible mechanism cervical provide new therapeutic target for treatment cancer, present study identified involved regulating cell metabolism cells. Liquid chromatography‑tandem mass spectrometry bioinformatic analyses...

10.3892/ijo.2020.5040 article EN International Journal of Oncology 2020-04-08

Cervical cancer is one of the most common malignant tumors in women all over world. However, exact etiology cervical remains unclear. The receptor for activated protein kinase C (RACK1) reported to be involved tumorigenesis and tumor progression. Besides, prognostic value RACK1 several kinds has been identified. there are limited studies on functional role cancer. In this study, we tested expression level by immunohistochemistry western blot technologies find that it upregulated Colony...

10.3892/ijo.2017.4137 article EN cc-by-nc-nd International Journal of Oncology 2017-09-27

Cancer stem cells (CSCs) are thought to be responsible for cancer progression and therapeutic resistance but identification of this subpopulation requires selective markers. Fortunately, side population (SP) analysis brings a novel method CSCs study. In study, we identified SP cells, which demonstrated rich in CSCs, four nasopharyngeal carcinoma (NPC) cell lines. We investigated from HK‐1 NPC line showed characteristics subpopulation. displayed greater proliferation invasion expressed high...

10.1002/mc.22279 article EN Molecular Carcinogenesis 2015-01-28

CD90, also known as Thy‑1 cell surface antigen, is located on human chromosome 11q23.3, and encodes a glycosylphosphatidylinositol‑linked glycoprotein. CD90 serves key role in malignancy by regulating proliferation, metastasis angiogenesis. Gastric cancer one of the most common types malignancy. Patients with advanced gastric have poor prognosis. plays occurrence progression cancer. However, molecular mechanism currently unclear. In order to identify which affects biological behavior energy...

10.3892/ol.2021.12451 article EN Oncology Letters 2021-01-07

<title>Abstract</title> The dangling bonds and surface defects at the grain boundaries of three-dimensional (3D) perovskite provide convenient conditions for non-radiative recombination ion migration, which degrades stability materials. Herein, we prepared single-component lateral epitaxial heterostructure perovskites using a one-step solution method by rare earth Er<sup>3+</sup> doping. Through photoluminescence (PL) time-resolved PL spectroscopy, erbium-doped...

10.21203/rs.3.rs-4634105/v1 preprint EN Research Square (Research Square) 2024-06-28

Abstract The realization of stable single‐component white light emission in metal halide perovskites is still challenging due to the fast ion migration and narrow luminescence bands. In this work, all‐inorganic single CsPbCl x Br 3−x perovskite microplates with red‐blue‐green triple color are prepared by introducing europium ions Eu 3+ as dopants. doping effectively suppresses enables two spatially separated phases dual‐wavelength emissions. Furthermore, incorporation compensates for absence...

10.1002/adfm.202416112 article EN Advanced Functional Materials 2024-11-03

A Yunnan branched-spike (Ynbs) barley mutant is useful for study of the genetic mechanisms underlying variation in spike architecture. In current study, a (Ynbs-1), recombinant inbred line (RIL-1), and cultivar (BDM-8) were used as parents to develop populations. Ynbs-1 exhibits typical branched spike, whereas others exhibit six-row spike. Genetic analysis on their F1, F2 F3 populations showed that one recessive gene responsible trait. SLAF marker generated from specific locus amplified...

10.1371/journal.pone.0227617 article EN cc-by PLoS ONE 2020-01-08
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