A5100386235- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Synthesis and Catalytic Reactions
- Cytokine Signaling Pathways and Interactions
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Rice Cultivation and Yield Improvement
- Advanced Glycation End Products research
- Ammonia Synthesis and Nitrogen Reduction
- Renin-Angiotensin System Studies
- Hormonal Regulation and Hypertension
- Nuclear Receptors and Signaling
- Nanoplatforms for cancer theranostics
- Click Chemistry and Applications
- Bone Metabolism and Diseases
- Natural Compounds in Disease Treatment
- Advanced Photocatalysis Techniques
- Inflammatory mediators and NSAID effects
- Adenosine and Purinergic Signaling
- Trace Elements in Health
- Apelin-related biomedical research
- Crop Yield and Soil Fertility
- Hydrogen Storage and Materials
- Neuroinflammation and Neurodegeneration Mechanisms
- Heavy metals in environment
Jiangxi Agricultural University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2024
Binzhou University
2023
Binzhou Medical University
2023
Affiliated Hospital of Hebei University
2022
China Medical University
2021
Guangdong Medical College
2021
Affiliated Hospital of Guangdong Medical College Hospital
2021
Tianjin Chest Hospital
2015-2020
Southeast University
2020
We recently found that microRNA-34a (miR-34a) is downregulated in human glioma tumors as compared to normal brain, and miR-34a levels mutant-p53 gliomas were lower than wildtype-p53 tumors. showed expression medulloblastoma cells inhibits cell proliferation, G1/S cycle progression, survival, migration invasion, but astrocytes does not affect survival cycle. uncovered the oncogenes c-Met, Notch-1 Notch-2 direct targets of are inhibited by transfection. c-Met specimens inversely correlate with...
The aim of the present study was to explore toxic effects and underlying mechanisms nickel ions during therapeutic nickel‑based alloy‑treatment in congenital heart disease by investigating metal‑induced cytotoxicity human monocyte‑derived macrophage cell line THP‑1. THP‑1 cells were treated with NiCl2·6H2O (25, 50, 100, 200, 400 800 µM) for 24, 48 72 h, respectively. MTT applied detect proliferation following NiCl2 treatment. Apoptosis quantified using flow cytometry. Illumina sequencing...
Cervical cancer is considered as a gynecological malignancy accompanied with high rates of mortality across the world. Effective diagnostic, prognostic markers well therapeutic targets are necessary to be explored. The p27 and PTEN known modulate tumor cell growth proliferation. However, molecular mechanisms modulating these genes have not completely been elucidated. In our study, real-time (RT) quantitative PCR indicated that miR‑940 levels were upregulated in human cervical tissue samples...
Growing evidence suggests that microRNA plays an essential role in the development and metastasis of many tumors, including gastric cancer. Aberrant miR-224 expression has been indicated tumor growth, mechanism promoting proliferation metastatic ability for cancer remains unclear. Accumulating reports mTOR signal pathway important cellular process, such as apoptosis, cell growth proliferation. The goal present study was to identify whether could inhibit migration, invasion, through targeting...
Atherosclerosis (AS) is the main cause of myocardial infarction and stroke. Macrophage apoptosis in early stages can attenuate lesions, while late stage it associated with AS plaque rupture.To explore effects miR-124-3p regulation p38MAPK signaling pathway via MEKK3 gene on proliferation macrophages mice coronary AS.Fifty male apolipoprotein E (ApoE) -/- were equally assigned to a normal group group. In group, given high-fat diet establish model. The isolated for culture divided into 7...
MicroRNAs (miRNAs/miR) often contribute to the progression of oral squamous cell carcinoma (OSCC) via regulation mRNA. The present study aimed investigate role miR‑198 in OSCC pathogenesis and explore underlying mechanism. Reverse transcription‑quantitative (RT‑q)PCR was performed determine expression tissues lines, univariate multivariate analyses were applied evaluate survival patients with OSCC. effects on lines studied <em>in vitro</em> vivo</em>. A set epithelial‑mesenchymal transition...
The present study aimed to investigate the function of miR-3529-3p in lung adenocarcinoma and MnO2 -SiO2 -APTES (MSA) as a promising multifunctional delivery agent for therapy.Expression levels were evaluated carcinoma cells tissues by qRT-PCR. effects on apoptosis, proliferation, metastasis neovascularization assessed CCK-8, FACS, transwell wound healing assays, tube formation xenografts experiments. Luciferase reporter western blot, qRT-PCR mitochondrial complex assay used determine...
In the immune system, Major Histocompatibility Complex class I (MHC-I) molecules are located on surface of most nucleated cells in vertebrates where they mediate responses. Accumulating evidence indicates that MHC-I also expressed central nervous system (CNS) play important roles significantly different from their functions. Classical temporally and spatially developing adult CNS, participate synaptic formation, remodeling plasticity. Therefore, clarifying regulation expression is necessary...
The global target profiling of Sofalcone identified HMGB1 as the key covalent for anti-inflammation activity in intestinal epithelial cells.
Emerging evidence greatly implicates that microRNA-450a (miR-450a) plays an essential role in cancer pathobiology. While the pathological of miR-450a breast carcinogenesis remains enigmatic. Herein, we showed was lowly expressed cell lines compared with normal, and low expression associated poor survival patients cancer. We revealed mimic transfected cells (T47D BT474) exhibited attenuated capacities proliferation, migration, invasion vitro, suppressed T47D growth a xenograft tumor model....
Abstract Tumors utilize many different escape mechanisms to evade anti-tumor immune responses. Xios Therapeutics has screened X-Chem’s proprietary 200-billion molecule DNA-encoded library against several immuno-oncology (IO) targets addressing T-cell centric, myeloid immunity and onco-metabolite pathways. Adenosine, for example, is a potent immunosuppressive metabolite, the ecto-5-nucleotidase (a.k.a. CD73), which catalyzes conversion of AMP adenosine, rate limiting enzyme production...
Abstract Glioblastoma is the most common and deadly malignant brain tumor. One main reason of resistance glioblastoma to therapy ability tumor cells migrate invade surrounding brain, rendering total surgical removal practically impossible. MicroRNAs are recently discovered small noncoding regulatory RNA molecules with emerging critical roles in cancer. modulate protein expression by binding 3′-untranslated region mRNA promoting degradation or inhibiting transcription. By acting on oncogenes...
Abstract Ovarian cancer is the most lethal gynecological worldwide, but underlying mechanism of ovarian malignancy acquirement largely unknown. miRNA ubiquitously implicated in disease especially initiation and progression. In current study, we firstly detected expression level miR-93-5p patient samples conducted a survival analysis. Our data revealed favorable prognostic factor downregulated patients. Secondly, CCK8 assay wound healing flow cytometry-based cell cycle analysis apoptotic were...