A5038685198- Acute Myeloid Leukemia Research
- Hemoglobinopathies and Related Disorders
- Frailty in Older Adults
- Circular RNAs in diseases
- Occupational and environmental lung diseases
- Cancer Immunotherapy and Biomarkers
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Iron Metabolism and Disorders
- Nutrition and Health in Aging
- Hematopoietic Stem Cell Transplantation
- MicroRNA in disease regulation
- RNA modifications and cancer
- Eosinophilic Disorders and Syndromes
- Neurological Complications and Syndromes
- Lung Cancer Treatments and Mutations
- Extracellular vesicles in disease
- Viral-associated cancers and disorders
- Palliative Care and End-of-Life Issues
- Histone Deacetylase Inhibitors Research
- Economic and Financial Impacts of Cancer
- T-cell and Retrovirus Studies
- Colorectal Cancer Surgical Treatments
- Synthesis and Catalytic Reactions
- Hematological disorders and diagnostics
- Gout, Hyperuricemia, Uric Acid
Dr. Georges-L.-Dumont University Hospital Centre
2017-2024
Vitalité Health Network
2024
Saint John Regional Hospital
2018
Background: Nivolumab was the first immuno-oncology agent available for treatment of lung cancer in Canada. In present study, we evaluated real-world benefit nivolumab Canadian patients with cancer. Methods: Patients included cohort were identified from a registry treated through expanded access to before and after Health Canada approval. Demographics collected application forms. Outcome data duration survival retrospectively. Results: contrast randomized clinical trial populations, our...
Liquid biopsy is a minimally-invasive diagnostic method that may improve access to molecular profiling for non-small cell lung cancer (NSCLC) patients. Although cell-free DNA (cf-DNA) isolation from plasma the standard liquid detecting mutations in patients, sensitivity can be highly variable. Vn96 peptide with an affinity both extracellular vesicles (EVs) and circulating cf-DNA. In this study, we evaluated whether peptide-affinity (PA) precipitation of EVs cf-DNA NSCLC patient improves...
Many patients with lower-risk myelodysplastic syndromes (LR MDS) require long-term red blood cell (RBC) transfusions to manage anemia. The consequences of RBC in LR MDS ring sideroblasts MDS-RS) are not well known. We estimated the association between cumulative dose density and clinical patient-reported outcomes using data from MDS-CAN registry for enrolled January 2008 December 2018. Outcomes included overall survival, hospitalization, health-related quality life (HRQoL). A total 145 RS...
Iron overload (IO) reflected by elevated ferritin is associated with increased mortality in myelodysplastic syndromes (MDS), however, an imperfect metric. Elevated labile plasma iron correlates clinical outcomes and transferrin saturation (TSAT) >80%, but not readily measurable. The trajectory of TSAT, its association remain undefined. Canadian MDS registry patients were evaluated. Mean mean transfusion dose density (TDD) determined. Survival was evaluated TSAT (<50%, 50-80%, >80%),...
Patients with lower-risk (LR) myelodysplastic syndromes (MDS) ring sideroblasts (RS) have better prognosis than those without RS, but how they fare over time is not fully understood. This study's objective was to assess the natural history of LR MDS RS ≥5% using MDS-CAN registry individual data. Kaplan–Meier estimates and generalized linear mixed models were used describe time-to-event outcomes continuous outcomes, respectively. One hundred thirty-eight patients enrolled; median times from...
The incorporation of patient-reported outcomes with traditional disease risk classification was found to strengthen survival prediction in patients myelodysplastic syndromes (MDS). In the present Canadian MDS registry analysis, we validate a recently reported prognostic model, Fatigue-International Prognostic Scoring System among higher-risk [FA-IPSS(h)], which incorporates patients' fatigue, assessed by European Organization for Research and Treatment Cancer (EORTC) Quality Life-Core 30...
The annual Eastern Canadian Gastrointestinal Cancer Consensus Conference 2017 was held in St. John's, Newfoundland and Labrador, 28-30 September. Experts radiation oncology, medical surgical cancer genetics who are involved the management of patients with gastrointestinal malignancies participated presentations discussion sessions for purpose developing recommendations presented here. This consensus statement addresses multiple topics gastric, rectal, colon cancer, including ■ identification...
The Pax-5 gene encodes a transcription factor that is essential for B-cell commitment and maturation. However, deregulation associated with various cancer lesions, notably hematopoietic cancers. Mechanistically, studies have characterized genetic alterations within the locus result in either dominant oncogenic function or haploinsufficiency-inducing mutations leading to oncogenesis. Apart from these mutations, some examples of aberrant expression cannot be alterations. In present study, we...
Abstract Introduction: B-cell cancers represent some of the most prevalent hematological lesions in adult and children. are also notable for their malignancy resistance to drug therapies. Our group studies oncogenes recently discovered that prominent PAX5 oncogene, which usually encodes transcription factors, generates non-coding circular RNA transcripts. Circular RNAs (circRNAs) a new class gene products involved many biological processes cancer disease. Due innate ability bind modulate...
Myelodysplastic syndromes (MDSs) treatment focuses on improving quality of life (QOL), affected by anemia and transfusion dependence (TD). Using the MDS-CAN registry, we studied how changes in status - TD to independence (TI) (group A), or vice versa B), maintaining C) TI D) OS QOL 1120 MDS patients. Analysis showed superior for those remaining TI, poorer TD, intermediate with changes. Among 656 treated patients, group A (
Despite advances in the field, a clear treatment algorithm for most peripheral T-cell lymphoma (PTCL) subtypes remains to be defined. Generating reliable randomized data this type of pathology challenge because relative rarity disease and heterogeneity subtypes. Newer agents, such as class-I selective histone deacetylase inhibitor romidepsin, have demonstrated efficacy manageable toxicity relapsed refractory setting. Whether novel agents should used conjunction with more conventional...
Abstract Circular RNAs (circRNAs) represent a new class of which are highly expressed and conserved in mammalian cells. CircRNAs regulate many biological processes their aberrant expression is often associated with disease progression. We have identified characterized circRNAs generated from the Pax-5 gene, an essential transcription factor for B-cell lineage commitment also, potent oncogene. Given pivotal role gene products development function, we set out to profile circular RNA (circPax5)...