A5019303615- Genetic diversity and population structure
- Genetic and phenotypic traits in livestock
- Wildlife Ecology and Conservation
- SARS-CoV-2 and COVID-19 Research
- Neuroscience and Neuropharmacology Research
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Malaria Research and Control
- Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Plant Parasitism and Resistance
- Galectins and Cancer Biology
- Advanced MRI Techniques and Applications
- Bacillus and Francisella bacterial research
- Heavy Metal Exposure and Toxicity
- Viral-associated cancers and disorders
- Bacteriophages and microbial interactions
- Evolution and Genetic Dynamics
- Viral gastroenteritis research and epidemiology
- Animal Behavior and Reproduction
- vaccines and immunoinformatics approaches
- Mosquito-borne diseases and control
- COVID-19 epidemiological studies
- Plant Pathogenic Bacteria Studies
- Plant-Microbe Interactions and Immunity
Centre for Cellular and Molecular Biology
2013-2022
SciGenom Labs (India)
2019-2022
Narayana Nethralaya
2021
Narayana Health
2019-2021
Tata Medical Center
2021
Abstract Species conservation can be improved by knowledge of evolutionary and genetic history. Tigers are among the most charismatic endangered species garner significant attention. However, their history genomic variation remain poorly known, especially for Indian tigers. With 70% world’s wild tigers living in India, such is critical. We re-sequenced 65 individual tiger genomes representing extant subspecies with a specific focus on from India. As suggested earlier studies, we found strong...
Abstract Knowledge of relationships in wild populations is critical for better understanding mating systems and inbreeding scenarios to inform conservation strategies endangered species. To delineate pedigrees populations, study genetic connectivity, genotype‐phenotype associations, trace individuals, or track wildlife trade, many identified individuals need be genotyped at thousands loci, mostly from noninvasive samples. This requires us (a) identify the most common sample available (b)...
In this study, we have evaluated cerebral atrophy, neurometabolite homeostasis, and neural energetics in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridin (MPTP) model of Parkinson's disease. addition, the efficacy acute l-DOPA treatment for reversal altered metabolic functions was also evaluated. Cerebral atrophy neurochemical profile were monitored vivo using MRI (1) H MR Spectroscopy. studied by H-[(13) C]-NMR spectroscopy conjunction with infusion (13) C labeled [1,6(-13) C2 ]glucose or...
First Zika virus (ZIKV) positive case from North India was detected on routine surveillance of Dengue-Like Illness in an 85-year old female. Objective the study to conduct investigation for epidemiological, clinical and genomic analysis first ZIKV outbreak Rajasthan, enhance surveillance. Outbreak performed 3 Km radius index among patient contacts, febrile cases, pregnant women. Routine enhanced include samples various districts Rajasthan. Presence serum urine by real time PCR test CDC...
Abstract Formulating strategies for species conservation requires knowledge of evolutionary and genetic history. Tigers are among the most charismatic endangered garner significant attention. However, history genomic variation tigers remain poorly known. With 70% worlds wild living in India, such is critical tiger conservation. We re-sequenced 65 individual genomes across their extant geographic range, representing subspecies with a specific focus on from India. As suggested by earlier...
Pseudomonas syringae-secreted HopA1 effectors are important determinants in host range expansion and increased pathogenicity. Their recent acquisitions via horizontal gene transfer several non-pathogenic strains worldwide have caused alarming increase their virulence capabilities. In Arabidopsis thaliana, RESISTANCE TO PSEUDOMONAS SYRINGAE 6 (RPS6) confers effector-triggered immunity (ETI) against HopA1pss derived from P. syringae pv. strain 61. Surprisingly, a closely related HopA1pst the...
Abstract Importance Novel SARS-CoV-2 virus has infected nearly half a billion people across the world and is highly contagious. There need for novel mechanism to block viral entry stop its replication. Background Spike protein N terminal domain (NTD) of essential replication in human cell. Thus S1 NTD coronavirus family, which similar galectin binding site - galactose lectins, potential target early treatment COVID-19. Objectives To study feasibility performing definitive trial using...
Abstract Wild pedigrees are critical for better understanding mating systems and inbreeding scenarios to inform conservation strategies endangered species. To delineate in wild populations, many identified individuals will have be genotyped at thousands of loci, mostly from non-invasive samples. This requires us quantify (a) the most common sample available (b) ability acquire genome-wide data such samples, (c) quality data, its reconstruct relationships between animals within a population....
Despite COVID vaccination with ChAdOx1 ncov-19 (COVISHIELD®) (ChAdOx1 ncov-19) a large number of healthcare workers (HCWs) were getting infected in wave-2 the pandemic cancer hospital India. It was important therefore to determine genotypes responsible for vaccine breakthrough infections.Retrospective observational study HCWs. Whole genome sequencing SARS CoV-2 using Illumina NovaSeq done. Mutations from both waves compared identify genomic correlates transmissibility and infections.Vaccine...
Importance: Novel SARS-CoV-2 virus has infected nearly 100 million people across the world and is highly contagious. There a need for novel mechanism to block viral entry stop its replication. Background: Spike protein N Terminal Domain (NTD) of essential and replication in human cell. Thus S1 NTD coronavirus family, which similar galectin binding site-human galactose binding lectins, potential target early treatment COVID-19. Objectives: To study feasibility performing definitive...
Background: Despite COVID vaccination with COVISHIELD vaccine (ChAdOx1 ncov-19) large number of healthcare workers (HCWs) was getting infected in wave-2 the pandemic a cancer hospital eastern part India.Methods: Retrospective observational study HCWs. Whole genome sequencing SARS CoV-2 using Illumina NovaSeq done. Mutations from both waves were compared to identify genomic correlates transmissibility and breakthrough infections.Findings: Vaccine infections seen 127 HCWs out 1,806 fully...