A5101855368- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer, Lipids, and Metabolism
- Liver Disease Diagnosis and Treatment
- Gallbladder and Bile Duct Disorders
- Bone health and treatments
- Bone Metabolism and Diseases
- Pediatric Hepatobiliary Diseases and Treatments
- Peptidase Inhibition and Analysis
- Diet and metabolism studies
- Estrogen and related hormone effects
- Cancer, Hypoxia, and Metabolism
- Diabetes Treatment and Management
- Neuroendocrine Tumor Research Advances
- Liver Disease and Transplantation
- Liver physiology and pathology
- Bariatric Surgery and Outcomes
- Hepatitis B Virus Studies
- Biliary and Gastrointestinal Fistulas
- Ferroptosis and cancer prognosis
- Drug Transport and Resistance Mechanisms
- Anesthesia and Pain Management
- Nutrition and Health in Aging
- Lung Cancer Research Studies
- IgG4-Related and Inflammatory Diseases
Agriculture and Forestry University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2023
Peking Union Medical College Hospital
2014-2023
Weatherford College
2021
Creative Commons
2021
Creative Research Enterprises (United States)
2015
Institute for Reproductive Health
2010
Peking University
2004-2010
Qujiang People's Hospital
2009
Sun Yat-sen University
2009
Background/Aims: The risk factors for cholangiocarcinoma are incompletely defined in China, especially intrahepatic (ICC). We evaluated the both ICC and extrahepatic (ECC). Methods: A case–control study which cases were patients referred to Peking Union Medical College Hospital (PUMCH) between 1998 2008 controls healthy individuals. Controls randomly selected from an existing database of individuals at Health Screening Center PUMCH. Data on liver disease, family history, diabetes, smoking...
FC1271a is a novel triphenylethylene compound with tissue-selective profile of estrogen agonistic and weak antagonistic effects. It specifically binds to the receptor α β affinity closely similar that toremifene tamoxifen. To study in vivo effects compound, 4-month-old rats were sham operated (sham) or ovariectomized (OVX) treated daily for 4 weeks various doses vehicle (orally). was able oppose OVX-induced bone loss by maintaining trabecular volume distal femur. Accordingly, strength...
Several members of the fibroblast growth factor (FGF) family have an important role in development skeletal tissues. FGF-8 is widely expressed developing skeleton, but its function there has remained unknown. We asked this study whether could a differentiation mesenchymal stem cells to osteoblastic lineage. Addition mouse bone marrow cultures effectively increased initial cell proliferation as well subsequent osteoblast-specific alkaline phosphatase production, nodule formation, and calcium...
Serum tumor markers such as alpha-fetoprotein (AFP), carcinoembryonic antigen, carbohydrate antigen (CA) 19-9, CA242, and CA50 were analyzed to evaluate their diagnostic values in single combined tests for distinguishing intrahepatic cholangiocarcinoma (ICC) from hepatocellular carcinoma (HCC). Preoperative serum levels of AFP, CA19-9, measured 45 ICC 76 HCC patients. The the positive rate CA242 significantly different between patients Although AFP (-) was most sensitive assay (91.1%), its...
Choledochal cysts are most common in Asian populations. In addition, the incidence of biliary tract malignancies from choledochal is increasing, but risk carcinogenesis still unclear.Clinical data 214 congenital cyst cases 1968 to 2013 were retrospectively analyzed.Todani type I was more (139, 65.0%) than IVa (53, 24.8%) or V (17, 7.9%) these patients. Biliary malignant tumors occurred gallbladder (2, 13.3%), bile duct (10, 66.7%), and intrahepatic (3, 20%) 15 patients (7.0%), including one...
<b>Background:</b> Kidney damage related to consumption of melamine-contaminated dairy products by young children in China has been described. However, no studies have reported on the population-based prevalence kidney among exposed or condition affected after follow-up. <b>Methods:</b> We conducted an ultrasound-based screening September 2008 7933 younger than 36 months age who lived a rural area where most highly contaminated with melamine were sold. monitored had evidence nephrolithiasis...
Background: Obstructive jaundice is one of the most common symptoms which can be caused by both malignant and benign hepato-biliary-pancreatic diseases.The differences differential diagnostic roles serum CA19-9, total bilirubin (TBIL) especially, ratio CA19-9 to TBIL in these patients have not been well elucidated.This study compared increase-folds 508 cases (MOJ) (BOJ) obstructive patients.Methods: Totally, with pathological results were retrospectively enrolled.342 MOJ, including...
Estrogens as well some antiestrogens have been shown to prevent bone loss in postmenopausal women. These compounds seem inhibit resorption, but their anabolic effects less explored. In this study, marrow cultures were used compare the effect of 17beta-estradiol (E2), and two triphenylethylene derivatives, tamoxifen (TAM), FC1271a, a benzothiophene derivative raloxifene (RAL) on differentiation osteoblasts. All enhanced osteoblastic 21-day indicated by increased mineralization nodule...
Curative hepatic resection (CHR) was a modality that provides possibility of long-term survival for hepatocellular carcinoma (HCC). So far, prognostic factors male patients with HCC after CHR remain unclear. Purposes the present study were to identify these and compare them those females.Consecutive 151 23 female undergoing enrolled in this retrospective study. Their identified by uni- multi-variate statistical analysis.One-, three- five-year overall disease-free 82.4, 51.5, 43.6%, 65.8,...
Patients with hepatocellular carcinoma (HCC) may develop paraneoplastic syndromes in the clinical course. These include hypercholesterolemia, hypoglycemia, hypercalcemia, and erythrocytosis, among others. This study was designed to assess role of prognostic influence patients HCC. In a cohort 175 HCC patients, we compared features or without syndromes. addition, survival rates individual those were also evaluated. Moreover, factors independently predicting prognosis analyzed. Among HCC, 54...
AIM:To investigate the impact of surgical procedures on prognosis gallbladder cancer patients classified with latest tumor-node-metastasis (TNM) staging system. METHODS:A retrospective study was performed by reviewing 152 primary carcinoma treated at Peking Union Medical College Hospital from January 2003 to June 2013.Postsurgical follow-up telephone and outpatient visits.Clinical records were reviewed grouped based new edition TNM system (AJCC, seventh edition, 2010).Prognoses analyzed...