A5007355610- Neurological Disease Mechanisms and Treatments
- Pomegranate: compositions and health benefits
- Laser Applications in Dentistry and Medicine
- Diet, Metabolism, and Disease
- Liver Disease Diagnosis and Treatment
- Dermatologic Treatments and Research
- Medical and Biological Ozone Research
- Neuroscience and Neuropharmacology Research
- Antioxidant Activity and Oxidative Stress
- Gut microbiota and health
- Phytochemicals and Antioxidant Activities
- Alcohol Consumption and Health Effects
- Metabolism and Genetic Disorders
- Neurological Disorders and Treatments
- Photodynamic Therapy Research Studies
- Bee Products Chemical Analysis
- Ferrocene Chemistry and Applications
- Clostridium difficile and Clostridium perfringens research
- Cholinesterase and Neurodegenerative Diseases
- Phytase and its Applications
- Lysosomal Storage Disorders Research
- Biomedical Research and Pathophysiology
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- MicroRNA in disease regulation
- Calcium signaling and nucleotide metabolism
Royal North Shore Hospital
2021-2025
The University of Sydney
2021-2025
First People's Hospital of Kunshan
2013
Jiangsu University
2013
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) is highly prevalent and has emerged as a pressing issue for human health. A palmitoylated cluster of differentiation 36 (CD36) promotes free fatty acid (FFA) uptake, which contributes to the development MASLD. Protocatechuic (PCA), main metabolite anthocyanins, was reported inhibit MASLD by regulating expression CD36. However, impact PCA on CD36 palmitoylation not been extensively studied. In present study, we found...
This study aims to investigate the effect of Urolithin A (UA) on diabetes-associated cognitive impairment in type 2 diabetes mellitus (T2DM) mouse model induced by high-fat diet (HFD) and streptozotocin (STZ).The UA-treated T2DM mice display an attenuated as well reduced levels metabolic endotoxemia proinflammatory cytokines serum. systemic restraint gut/brain inflammation is also observed downregulation TLR4 Myd88 colon along with inhibition GFAP, Iba-1, NLRP3, inflammation-related genes...
Abstract Combating the accumulated senescent cells and healing of osteoporotic bone fractures in older remains a significant challenge. Nicotinamide mononucleotide (NMN), precursor NAD+, is an excellent candidate for mitigating aging-related disorders. However, it unknown if NMN can alleviate cell induction enhance fracture healing. Here we show that treatment partially reverses effects tumor necrosis factor-alpha (TNF-α) on human primary osteoblasts (HOBs): induction, diminished osteogenic...
This study aims to investigate the effect and mechanism of Urolithin A (UA) on neuronal stress damage cognitive impairment in type 2 diabetes mellitus (T2DM) mouse model induced by high-fat diet (HFD) streptozotocin (STZ).T2DM mice fed with UA display an attenuated along suppressed endoplasmic reticulum (ER) Tau hyperphosphorylation brain. Similar restraint ER is also observed high glucose-treated primary hippocampal neurons. Moreover, ameliorates oxidative stress, aberrant energy...
EA enhanced the abundance of beneficial bacteria as well their derived metabolites, thereby inhibiting chronic alcohol-induced neuroinflammation via regulation gut microbiota-mediated CCL21-CCR7 axis, ultimately ameliorating AICSD.
Alcohol-related liver disease (ALD) encompasses a spectrum of hepatic disorders resulting from alcohol abuse, which constitutes the predominant etiology morbidity and mortality associated with pathologies globally. Excessive consumption disrupts integrity intestinal barrier perturbs balance gut microbiota, thereby facilitating progression ALD. Ellagic acid (EA) has been extensively reported to be an effective intervention for alleviating symptoms. However, target molecules EA in improving...
Chronic kidney disease (CKD) is a worldwide public health problem, resulting in significant burden on the system. PBM effective mitigating inflammation, mitochondrial dysfunction, and oxidative stress, all of which are factors inherent CKD. The aim this study was to identify direct effects an in-vitro model In vitro human proximal tubular cells (HK2 cells) were pre-treated with low (1.38 J/cm<sup>2</sup>) or high dosage (2.75J/cm<sup>2</sup>) PBM. Cells then incubated TGF-β1 (2 ng/ml)...