A5035018718- Pharmacological Effects and Toxicity Studies
- Drug Transport and Resistance Mechanisms
- Neuropeptides and Animal Physiology
- 3D Printing in Biomedical Research
- Genetic Mapping and Diversity in Plants and Animals
- Cancer, Stress, Anesthesia, and Immune Response
- Neuroscience and Neuropharmacology Research
- Analytical Methods in Pharmaceuticals
- Spaceflight effects on biology
- Adipose Tissue and Metabolism
- Antibiotics Pharmacokinetics and Efficacy
- Fibroblast Growth Factor Research
- Bioinformatics and Genomic Networks
- Computational Drug Discovery Methods
- Hippo pathway signaling and YAP/TAZ
- Epilepsy research and treatment
- Anesthesia and Sedative Agents
- Pregnancy and preeclampsia studies
- Pharmacology and Obesity Treatment
- Wnt/β-catenin signaling in development and cancer
- Epigenetics and DNA Methylation
- Pregnancy and Medication Impact
- Histone Deacetylase Inhibitors Research
- Radiation Therapy and Dosimetry
Hebrew University of Jerusalem
2021-2024
University of Guelph
2018
Tel Aviv University
2016
Our goal was to test the feasibility of a new theranostic strategy in chronic epilepsy by targeting cathepsin function using novel activity-based probes (ABPs). We assessed biodistribution fluorescent ABPs vivo, vitro, and ex rodents with pilocarpine-induced naïve controls, human epileptic tissue, myeloid cell lines RAW 264.7 (monocytes) BV2 (microglia). Distribution localization were studied fluorescence scanning, immunoblotting, microscopy, cross-section staining anesthetized animals,...
A recent review by Odi et al. provided important information on the physicochemical and biopharmaceutical properties of antiseizure medications (ASMs).1 The authors included marketed ASMs, ASMs in development, those that reached clinical trials but did not make it to market. Based analysis, a set was suggested as screening tool be used early developmental stages small molecule intended for oral dosing. These influence permeability drugs across membranes, which is critical their absorption,...
Osteosarcoma (OSA) is the most common bone cancer in canines. Both transforming growth factor beta (TGFβ) and Hippo pathway mediators have important roles development, stemness, progression. The role of signalling effectors TAZ YAP has never been addressed canine OSA. Further, cooperative TGFβ yet to be explored osteosarcoma. To address these gaps, this study investigated prognostic value alone combination with pSmad2 (a marker active signalling), as well involvement a TGFβ-Hippo crosstalk...
To investigate the comparative antiseizure activity of individual enantiomers fenfluramine and its major active primary metabolite norfenfluramine in rodent seizure models, relationship with pharmacokinetics these compounds plasma brain.The potency d,l-fenfluramine (racemic fenfluramine) was compared respective potencies using maximal electroshock (MES) test rats mice, 6-Hz 44 mA mice. Minimal motor impairment assessed simultaneously. The time course protection concentration profiles...
We recently demonstrated that the histone deacetylase inhibitor valproic acid (VPA) reprograms cisplatin-induced metabolome of triple-negative breast cancer (TNBC) cells, including a shift in hexose levels. Accordingly, here, we tested hypothesis VPA alters glucose metabolism correlation with cisplatin sensitivity. Two TNBC cell lines, MDA-MB-231 (a cisplatin-resistant line) and MDA-MB-436 cisplatin-sensitive line), were analyzed. The glycolysis oxidative measured using Glycolysis Stress...
A central challenge in pharmaceutical research is to investigate genetic variation response drugs. The Collaborative Cross (CC) mouse reference population a promising model for pharmacogenomic studies because of its large amount variation, reproducibility, and dense recombination sites. While the CC lines are phenotypically diverse, their diversity drug disposition processes, such as detoxification reactions, still largely uncharacterized. Here we systematically measured RNA-sequencing...
Abstract The effect of fenfluramine and norfenfluramine enantiomers in rodent seizure models their correlation with the pharmacokinetics d ‐ l ‐fenfluramine rats have been reported recently. To complement these findings, we investigated rat plasma brain. Sprague‐Dawley were injected intraperitoneally 20 mg/kg 1 norfenfluramine. A dose ‐norfenfluramine was used because higher doses caused severe toxicity. concentration each enantiomer brain determined at different time points by liquid...
The space environment can affect the function of all physiological systems, including properties cell membranes. Our goal in this study was to explore effect simulated microgravity (SMG) on cellular uptake small molecules based reported microgravity-induced changes membrane properties. SMG applied cultured cells using a random-positioning machine for up three hours. We assessed accumulation compounds representing substrates and efflux transporters, not shown be transported by carriers....