A5013719566- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- EEG and Brain-Computer Interfaces
- Neuroscience and Neuropharmacology Research
- Functional Brain Connectivity Studies
- Metabolism and Genetic Disorders
- Pharmaceutical studies and practices
- Neuroscience and Neural Engineering
- Psychosomatic Disorders and Their Treatments
- Glycogen Storage Diseases and Myoclonus
- Diet and metabolism studies
- Neural dynamics and brain function
- Neonatal and fetal brain pathology
- Drug Transport and Resistance Mechanisms
- Ethnobotanical and Medicinal Plants Studies
- Transcranial Magnetic Stimulation Studies
- Trace Elements in Health
- Complementary and Alternative Medicine Studies
- Multiple Sclerosis Research Studies
- Health Systems, Economic Evaluations, Quality of Life
- Mental Health and Psychiatry
- Olfactory and Sensory Function Studies
- Obsessive-Compulsive Spectrum Disorders
- Fractal and DNA sequence analysis
- Pneumocystis jirovecii pneumonia detection and treatment
Hadassah Medical Center
2016-2025
Hebrew University of Jerusalem
2014-2025
University of California, Los Angeles
2022
Carlo Forlanini Hospital
2022
Schneider Children's Medical Center
2008-2016
Sheba Medical Center
2016
Tel Aviv University
2016
Austin Health
2016
Tel Aviv Sourasky Medical Center
2016
Beth Israel Deaconess Medical Center
2009-2010
Paroxysmal exercise-induced dyskinesia (PED) can occur in isolation or association with epilepsy, but the genetic causes and pathophysiological mechanisms are still poorly understood. We performed a clinical evaluation analysis five-generation family co-occurrence of PED epilepsy (n = 39), suggesting that this combination represents entity. Based on whole genome linkage we screened SLC2A1, encoding glucose transporter blood-brain-barrier, GLUT1 identified heterozygous missense frameshift...
Epilepsy surgery is the treatment of choice for patients with drug-resistant seizures. A timely evaluation surgical candidacy can be life-saving who are identified as appropriate candidates, and may also enhance care nonsurgical candidates through improvement in diagnosis, optimization therapy, comorbidities. Yet, referral evaluations often delayed while palliative options pursued, significant adverse consequences due to increased morbidity mortality associated intractable epilepsy. The...
Summary Purpose: Ictal video–electroencephalography (EEG) is commonly used to establish ictal onset‐zone location. Recently software development has enabled systematic studies of magnetoencephalography (MEG). In this article, we evaluate the ability MEG signals localize seizure‐onset zone. Methods: Twenty‐six patients underwent and epilepsy surgery. Prediction zone by interictal was retrospectively compared with ictal‐onset area found intracranial EEG in 12 patients. The specificity...
Cathodal transcranial direct current stimulation (tDCS) is a focal neuromodulation technique that suppresses cortical excitability by low-amplitude constant electrical current, and may have an antiepileptic effect. Yet, tDCS has not been tested in status epilepticus (SE). Furthermore, combined pharmacotherapy antiseizure approach unexplored. We therefore examined the rat pentylenetetrazol (PTZ) SE model whether cathodal (1) seizures, (2) augments lorazepam (LZP) efficacy, (3) enhances...
Abstract Temporal lobe epilepsy (TLE) is the most common focal seizure disorder in adults. In many patients, transient brain insults, including status epilepticus (SE), are followed by a latent period of epileptogenesis, preceding emergence clinical seizures. experimental animals, transcriptional upregulation Ca V 3.2 T-type 2+ -channels, resulting an increased propensity for burst discharges hippocampal neurons, important trigger epileptogenesis. Here we provide evidence that...
Cortical traveling waves, defined by their spatial, temporal, and frequency characteristics, provide key insights into active brain regions, timing, frequency, the direction of activity propagation. Emerging evidence suggests that directionality spatiotemporal extent these waves encode cognitive processes. However, relationship between this encoding mechanism remains unclear. We investigate hypothesis coherence determines wave propagation velocity. By employing both bivariate linear...
Alterations in the default mode network (DMN) are associated with aging. We assessed age-dependent changes of DMN interactions and correlations a battery neuropsychological tests, to understand differences directed connectivity between young older subjects. Using novel multivariate analysis method on resting-state functional MRI data from fifty thirty-one healthy subjects, we calculated intra- inter-DMN 4-nodes pathways. For old subject group, partial pathways with: psychomotor speed working...
To analyze the clinical syndromes and inheritance patterns of multiplex families with epilepsy toward ultimate aim uncovering underlying molecular genetic basis.Following referral 2 or more relatives epilepsy, individuals were classified into syndromes. Families where at least family members had a specific diagnosis. Pedigrees analyzed studies performed as appropriate.A total 211 ascertained over an 11-year period in Israel. A 169 broad familial syndrome groups: 61 generalized, 22 focal, 24...
Our goal was to test the feasibility of a new theranostic strategy in chronic epilepsy by targeting cathepsin function using novel activity-based probes (ABPs). We assessed biodistribution fluorescent ABPs vivo, vitro, and ex rodents with pilocarpine-induced naïve controls, human epileptic tissue, myeloid cell lines RAW 264.7 (monocytes) BV2 (microglia). Distribution localization were studied fluorescence scanning, immunoblotting, microscopy, cross-section staining anesthetized animals,...
Summary Paroxysmal exercise‐induced dyskinesia (PED) and epilepsy without intellectual disability have recently been recognized as manifestations of deficiency the glucose transporter GLUT1, due to mutations in gene SLC2A1 . We describe a family with six definitely affected members two generations. Two had PED, three epilepsy, one both. A missense mutation (c.950A>C; p.N317T) was detected five living members, but absent nonaffected first‐degree subject believed be phenocopy. The clinical...
Inflammation is a hallmark of epileptogenic brain tissue. Previously, we have shown that inflammation in epilepsy can be delineated using systemically-injected fluorescent and magnetite- laden nanoparticles. Suggested mechanisms included distribution free nanoparticles across compromised blood-brain barrier or their transfer by monocytes infiltrate the epileptic brain.In current study, evaluated as vehicles deliver into brain. We also assessed effect on systemic nanoparticleloaded...
Our goal was to measure the absolute differential abundance of key drug transporters in human epileptogenic brain tissue and compare them between patients at various distances from zone within same patient. Transporter protein quantified homogenates who underwent epilepsy surgery, using targeted proteomics, correlations with clinical characteristics were assessed. Fourteen samples (including four hippocampal samples) collected nine patients. Among quantifiable transporters, (median, range)...