A5067660988- Functional Brain Connectivity Studies
- Transcranial Magnetic Stimulation Studies
- Epilepsy research and treatment
- EEG and Brain-Computer Interfaces
- Advanced MRI Techniques and Applications
- Neurological disorders and treatments
- Neurobiology of Language and Bilingualism
- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Pharmacological Effects and Toxicity Studies
- Prion Diseases and Protein Misfolding
- Neural and Behavioral Psychology Studies
- Neuroscience and Neural Engineering
- Pain Management and Treatment
- Muscle activation and electromyography studies
- Intraoperative Neuromonitoring and Anesthetic Effects
- Genetic Neurodegenerative Diseases
- Complex Systems and Time Series Analysis
- Video Analysis and Summarization
- Advanced Neuroimaging Techniques and Applications
- Meningioma and schwannoma management
- Diet and metabolism studies
- Children's Physical and Motor Development
- Autoimmune Neurological Disorders and Treatments
- Neonatal and fetal brain pathology
Helsinki University Hospital
2010-2024
University of Helsinki
2016-2024
Aalto University
2023
Hospital District of Helsinki and Uusimaa
2011-2013
Imaging Center
2013
Summary Purpose: Ictal video–electroencephalography (EEG) is commonly used to establish ictal onset‐zone location. Recently software development has enabled systematic studies of magnetoencephalography (MEG). In this article, we evaluate the ability MEG signals localize seizure‐onset zone. Methods: Twenty‐six patients underwent and epilepsy surgery. Prediction zone by interictal was retrospectively compared with ictal‐onset area found intracranial EEG in 12 patients. The specificity...
Summary Objective Navigated transcranial magnetic stimulation ( nTMS ) is becoming increasingly popular in noninvasive preoperative language mapping, as its results correlate well enough with those obtained by direct cortical DCS during awake surgery adult patients tumor. Reports the context of epilepsy or extraoperative adults are, however, sparse, and validation children lacking. Furthermore, little known about risk inducing epileptic seizures pediatric patients. We provide largest study...
To examine the usability of long-range temporal correlations (LRTCs) in non-invasive localization epileptogenic zone (EZ) refractory parietal lobe epilepsy (RPLE) patients. We analyzed 10 RPLE patients who had presurgical MEG and underwent surgery. quantified LRTCs with detrended fluctuation analysis (DFA) at four frequency bands for 200 cortical regions estimated using individual source models. correlated individually DFA maps to distance from resection area locations interictal...
This study was undertaken to investigate the potential of interictal electroencephalographic (EEG) findings and electrically stimulated seizures during stereo-EEG (SEEG) as surrogate markers for spontaneous seizure onset zone (spSOZ). We hypothesized that combining localizing information these would allow clinically meaningful estimation spSOZ.
To evaluate a novel analysis method (SAMepi) in the localization of interictal epileptiform magnetoencephalographic (MEG) activity parietal lobe epilepsy (PLE) patients comparison with equivalent current dipole (ECD) analysis.We analyzed preoperative MEG 17 operated PLE utilizing visual and: (1) ECD spherical conductor model; (2) boundary element (BEM) and (3) SAMepi - kurtosis beamformer method. Localization results were compared between three methods, to location resection clinical...
The cortical areas involved in human speech should be characterized reliably prior to surgery for brain tumors or drug-resistant epilepsy. functional mapping of language surgical decision-making is usually done invasively by electrical direct stimulation (DCS), which used identify the organization crucial and subcortical structures within each patient. Accurate preoperative non-invasive aids planning, reduces time, costs, risks operating room, provides an alternative patients not suitable...
The intracarotid amobarbital procedure (IAP) is the current "gold standard" in preoperative assessment of language lateralization epilepsy surgery candidates. It is, however, invasive and has several limitations. Here we tested a simple noninvasive test performed with magnetoencephalography (MEG).We recorded auditory MEG responses to pairs vowels pure tones 16 candidates who had undergone IAP. For each individual, selected pair planar gradiometer sensors strongest N100m response hemisphere...
Article The functional connectivity of the prefrontal cortex studied by combined TMS with EEG was published on January 1, 2001 in journal Biomedical Engineering / Biomedizinische Technik (volume 46, issue s2).
Creutzfeldt-Jakob disease (CJD) is a rare neurodegenerative with no effective therapy available. We recorded spontaneous magnetoencephalography and auditory evoked fields (AEFs) from male patient rapidly progressive memory disorder, ataxia myoclonus. Post-mortem examination confirmed sporadic CJD. Sources of the abnormal slow wave activity were localized beamformer software. sharp transients AEFs modeled equivalent current dipoles. The estimated sources abnormalities more dominant in left...
The cortical areas involved in human speech should be characterized reliably prior to surgery for brain tumors or drug-resistant epilepsy. functional mapping of language surgical decision-making is usually done invasively by electrical direct stimulation (DCS), which used identify the organization crucial and subcortical structures within each patient. Accurate preoperative non-invasive aids planning, reduces time, costs, risks operating room, provides an alternative patients not suitable...