A5101431510- Advanced Multi-Objective Optimization Algorithms
- Low-power high-performance VLSI design
- Cardiac Imaging and Diagnostics
- Metaheuristic Optimization Algorithms Research
- Machine Learning and Data Classification
- Advanced Bandit Algorithms Research
- Advancements in Semiconductor Devices and Circuit Design
- Advanced MRI Techniques and Applications
- Cardiovascular Disease and Adiposity
- Cardiovascular Function and Risk Factors
- Analog and Mixed-Signal Circuit Design
- Semiconductor materials and devices
- Heart Rate Variability and Autonomic Control
- Blind Source Separation Techniques
- Evolutionary Algorithms and Applications
- Insect and Pesticide Research
- Cryptography and Data Security
- HIV/AIDS drug development and treatment
- VLSI and FPGA Design Techniques
- Insect-Plant Interactions and Control
- Numerical Methods and Algorithms
- Cardiac electrophysiology and arrhythmias
- Advanced Memory and Neural Computing
- Atomic and Subatomic Physics Research
- Interconnection Networks and Systems
Mitsui Chemicals (Germany)
2023-2024
CyberAgent (Japan)
2021-2024
Shibuya (Japan)
2022-2024
Yokohama National University
2024
Tokyo Institute of Technology
2021-2024
University of Toyama
2024
National Center for Global Health and Medicine
2021
Chiba Keizai University
2018
Semiconductor Energy Laboratory (Japan)
2010-2012
Renesas Electronics (Japan)
2011-2012
Practitioners often encounter challenging real-world problems that involve a simultaneous optimization of multiple objectives in complex search space. To address these problems, we propose practical multiobjective Bayesian algorithm. It is an extension the widely used Tree-structured Parzen Estimator (TPE) algorithm, called Multiobjective (MOTPE). We demonstrate MOTPE approximates Pareto fronts variety benchmark and convolutional neural network design problem better than existing methods...
To help overcome limits to the speed of conventional SRAMs, we have developed a read-static-noise-margin-free SRAM cell. It consists seven transistors, several which are low-Vth nMOS transistors used achieve both low-VDD and high-speed operations. For same speed, area our proposed is 23% smaller than that SRAM. Further, fabricated 64-kb macro using 90-nm CMOS technology obtained with it minimum VDD 440 mV 20-ns access time 0.5-V supply.
The covariance matrix adaptation evolution strategy (CMA-ES) has been highly effective in black-box continuous optimization, as demonstrated by its success both benchmark problems and various real-world applications. To address the need for an accessible yet potent tool this domain, we developed cmaes, a simple practical Python library CMA-ES. cmaes is characterized simplicity, offering intuitive use high code readability. This makes it suitable quickly using CMA-ES, well educational...
This study targets the mixed-integer black-box optimization (MI-BBO) problem where continuous and integer variables should be optimized simultaneously. The CMA-ES, our focus in this study, is a population-based stochastic search method that samples solution candidates from multivariate Gaussian distribution (MGD), which shows excellent performance BBO. parameters of MGD, mean (co)variance, are updated based on evaluation value candidate solutions CMA-ES. If CMA-ES applied to MI-BBO with...
The 3-GeV rapid cycling synchrotron (RCS) of the Japan Proton Accelerator Research Complex (J-PARC) was commissioned in October 2007, and successfully accomplished 3 GeV acceleration on 31. Six run cycles through February 2008 were dedicated to commissioning RCS, for which initial machine parameter tuning various underlying beam studies completed. Then since May RCS has been delivered downstream facilities their commissioning. In this paper we describe study results following our scenario a...
ABSTRACT To examine interspecific variation in the intensity of ant defense among three sympatric species obligate myrme‐cophytes Macaranga (Euphorbiaceae), we measured ratio biomass to plant biomass, aggressiveness artificial damage on host plants, and increase herbivore plants when symbiont ants were removed. Increase from two‐ four‐week exclusion varied significantly species. The decreasing order vulnerability herbivory was M. winkleri, trachyphylla , beccariana. antip/ant (= rate dry...
Hyperparameter optimization (HPO), formulated as black-box (BBO), is recognized essential for automation and high performance of machine learning approaches. The CMA-ES a promising BBO approach with degree parallelism, has been applied to HPO tasks, often under parallel implementation, shown superior other approaches including Bayesian (BO). However, if the budget hyperparameter evaluations severely limited, which case end users who do not deserve computing, exhausts without improving due...
The synthesis and in vitro anti-HIV activity of two new racemic nucleoside analogues are described; namely, 9-[c-4,t-5-bis(hydroxymethyl)cyclopent-2-en-r-1-yl]-9H-adenine (12) its guanine analogue 18. While the latter (18) showed no activity, therapeutic index former was 200 comparable to that (400) carbovir. One enantiomer 12 may be viewed as an carbocyclic oxetanocin other Hence, these results indicate one or both individual enantiomers could serve candidates lead compounds for development...
Flometoquin, 2-ethyl-3,7-dimethyl-6-[4-(trifluoromethoxy)phenoxy]quinolin-4-yl methyl carbonate, is a novel insecticide with structurally unique phenoxy-quinoline. It was discovered in 2004 by the collaborative research of Nippon Kayaku and Meiji Seika Kaisha, Ltd. (currently, Mitsui Chemicals Crop & Life Solutions, Inc.). The compound demonstrates strong quick insecticidal action against variety thrips species at nymphal adult stages through contact feeding activity, which could minimize...
A new hierarchical cell SRAM architecture, combined with a multi-step word-line control technology, has been developed to overcome rapid increase in random variability no area-penalty. 40nm-node 0.248 μm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> -cell using single power supply successfully fabricated, pushing up bit-density 2.98Mb/mm .
AVS technique for extremely scaled SoCs has been developed. To reduce design cost, we have developed a supply voltage control scheme employing universal delay line (UDL), rather than replica line, monitoring the critical path (T <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">CRIT</sub> ). The UDL can be used in any product without need customizing. In addition, averaging results of distributed 4 monitors with pitch 3 mm chip errors due to...
In this paper, a closed-form expression for estimating minimum operating voltage (VDDmin) of CMOS logic gates is proposed. VDDmin defined as the supply at which circuits can operate correctly. combinational be written linear function square-root logarithm number and its slope proportional to standard deviation within-die variation in threshold difference between PMOS NMOS transistors. The proposed verified with Monte Carlo simulations using various gate chains. verification reveals that...
Many of us in the field ultra-low-V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">dd</sub> processors experience difficulty assessing sub/near threshold circuit techniques proposed by earlier papers. This paper investigates five major pitfalls which are often not appreciated researchers when claiming that their circuits outperform others working at a lower V with higher energy-efficiency. These include: i) overlook impacts different...
A multi-step word-line control technology (MWC), combined with a new hierarchical cell SRAM architecture (HCA), has been developed to overcome rapid increase in random variability no area penalty. 40-nm-node 0.248- <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$\mu$</tex></formula> m xmlns:xlink="http://www.w3.org/1999/xlink"> <tex Notation="TeX">$^{2}$</tex></formula> -cell using single power...
The magnetocardiogram (MCG) is a newly developed method that helps localize cardiac current source. To test the clinical accuracy of 7-channel biomagnetic system in localization early ventricular depolarization sites, MCGs 14 patients with Wolff-Parkinson-White (WPW) syndrome were recorded radiofrequency-shielded room. locations sites classified by standard 12-lead electrocardiograms (ECGs) and body surface isopotential mapping. accessory pathways 3 WPW located right free wall 11 left wall....
Studying how objects are positioned is vital for improving technologies like robots, cameras, and virtual reality. In our earlier papers, we introduced a bio-inspired artificial visual system orientation detection, demonstrating its superiority over traditional systems with higher recognition rates, greater biological resemblance, increased resistance to noise. this paper, propose hardware-based detection (ODS). The ODS implemented by multiple dendritic neuron model (DNM), neuronal pruning...
An unusual pheochromocytoma was incidentally discovered in a 48-year-old woman. The patient had 3-year history of myasthenia gravis. At the time examination our hospital, right adrenal tumor by ultrasonography abdomen. She no headache, perspiration, palpitation or hypertension. Although blood catecholamine levels were within normal limits, urinary secretion elevated. Histologically, diagnosed to be mixed ganglioneuroma/pheochromocytoma and histochemically confirmed produce vasoactive...
Determinant factors of the minimum operating voltage (V DDmin ) CMOS logic gates are investigated by measurements logic-gate chains in 65nm CMOS. V consists a systematic component DDmin(SYS) and random variation DDmin(RAND) ). is minimized, when threshold equals to half supply DD The tuning each gate achieved sizing width nMOS/pMOS. minimized reducing increasing or forward body biasing. In addition, temperature dependence measured for first time. worst corner analysis should be changed...
Contention-less flip-flops (CLFF's) and separated power supply voltages (V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DD</sub> ) between (FF's) combinational logics are proposed to achieve a maximum energy efficiency operation. The technologies were applied 16-bit integer unit (IU) for media processing in 65-nm CMOS process. Measurement results of fabricated chips show that the CLFF reduces minimum operating voltage IU's by 64mV on average....
Determinant factors of the minimum operating voltage (V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DDmin</sub> ) CMOS logic gates are investigated by measurements logic-gate chains in 65nm CMOS. V consists a systematic component xmlns:xlink="http://www.w3.org/1999/xlink">DDmin(SYS)</sub> and random variation xmlns:xlink="http://www.w3.org/1999/xlink">DDmin(RAND)</sub> ). is minimized, when threshold equals to half supply...
This paper presents a natural evolution strategy for implicitly constrained black-box function optimization. The optimization is challenging because explicit representations of objective functions are not given, and only evaluation values solutions can be used. In problems, constraints explicitly the feasibility solution obtained when evaluated. other words, amount constraint violation cannot obtained, which makes difficult. Natural Evolution Strategies (NES) one promising frameworks DX-NES...
Abstract Background Methotrexate (MTX) is a frequently used drug in the treatment of rheumatoid arthritis (RA), but occurrences lymphoproliferative disorders (LPD) have been reported patients undergoing an MTX regimen. Almost half with methotrexate-associated (MTX-LPD) extranodal lesions; moreover, although extremely rare, digestive tract perforations resulting from lesions MTX-LPD also reported. Case presentation We describe case 81-year-old woman RA who had prescribed at 6 mg per week for...