A5007543466- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Genetics and Neurodevelopmental Disorders
- Mitochondrial Function and Pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Epigenetics and DNA Methylation
- Alzheimer's disease research and treatments
- Sleep and Wakefulness Research
- RNA Research and Splicing
- Genetics, Aging, and Longevity in Model Organisms
- Neurological disorders and treatments
- Bioinformatics and Genomic Networks
- Genetic Neurodegenerative Diseases
- Birth, Development, and Health
- Dementia and Cognitive Impairment Research
- Neurogenesis and neuroplasticity mechanisms
- Protein Structure and Dynamics
- Genomics and Rare Diseases
- Health, Environment, Cognitive Aging
- Cell Image Analysis Techniques
- Cognitive Abilities and Testing
- Neural and Behavioral Psychology Studies
- Cardiovascular Health and Risk Factors
- Genomics and Chromatin Dynamics
Loyola University Maryland
2024
National Institute on Aging
2019-2022
National Institutes of Health
2019-2022
University of Bergen
2012-2018
Haukeland University Hospital
2015-2017
The immediate early gene product Arc (activity-regulated cytoskeleton-associated protein) is posited as a master regulator of long-term synaptic plasticity and memory. However, the physicochemical structural properties have not been elucidated. In present study, we expressed purified recombinant human (hArc) performed first biochemical biophysical analysis hArc's structure stability. Limited proteolysis assays MS indicate that hArc has two major domains on either side central more disordered...
Activity-regulated cytoskeleton-associated protein, Arc, is a major regulator of long-term synaptic plasticity and memory formation. Here we reveal novel interaction partner resident endoplasmic reticulum transmembrane calnexin. We show an between recombinantly-expressed GST-tagged Arc endogenous calnexin in HEK293, SH-SY5Y neuroblastoma PC12 cells. The was dependent on the central linker region protein that also required for endocytosis AMPA-type glutamate receptors. High-resolution...
Cognitive functions are highly heritable and polygenic, though the source of this genetic influence is unclear. On neurobiological level, these rely on effective neuroplasticity, in which activity-regulated cytoskeleton associated protein (ARC) plays an essential role.To examine whether ARC gene complex may contribute to components intellectual function given crucial role brain plasticity memory formation.The was tested for association with intelligence (IQ) children from Avon Longitudinal...
Abstract Introduction Intelligence is a core construct of individual differences in cognitive abilities and strong predictor important life outcomes. Within recent years, rates cesarean section have substantially increased globally, though little known about its effect on neurodevelopmental trajectories. Thus, we aimed to investigate the influence delivery by genetics intelligence children. Methods Participants were recruited through Avon Longitudinal Study Parents Children (ALSPAC). was...
Introduction The Activity-Regulated Cytoskeleton-associated (ARC) gene encodes a protein that is critical for the consolidation of synaptic plasticity and long-term memory formation. Given ARC's key role in plasticity, we hypothesized genetic variations ARC may contribute to interindividual variability human cognitive abilities or attention-deficit hyperactivity disorder (ADHD) susceptibility, where impairment often accompanies disorder. Methods We tested whether variants are associated with...
ABSTRACT Changes in neuronal network activity and increased interindividual variability memory are among the most consistent features of growing older. Here, we examined relationship between these hallmarks aging. Young aged rats were trained on a water maze task where individuals reliably display an range spatial capacities relative to young. Two weeks later, was induced pharmacologically with low dose pilocarpine control animals received vehicle. Activity levels proxied by quantifying...
A ubiquitous observation among cognitive aging studies across species is the substantial increase in interindividual variability of capacities, most notably episodic memory and working memory, with age ([Rapp, 2009][1]; [Morrison Baxter, 2012][2]). Anecdotal accounts