A5021723671- Microbial Metabolic Engineering and Bioproduction
- Gene Regulatory Network Analysis
- Photosynthetic Processes and Mechanisms
- Algal biology and biofuel production
- Biofuel production and bioconversion
- Enzyme Catalysis and Immobilization
- Airway Management and Intubation Techniques
- Bioinformatics and Genomic Networks
- Gut microbiota and health
- Probiotics and Fermented Foods
- Plant biochemistry and biosynthesis
- Advanced Biosensing Techniques and Applications
- Microbial Community Ecology and Physiology
- Microfluidic and Capillary Electrophoresis Applications
- Aquatic Ecosystems and Phytoplankton Dynamics
- Global Health and Epidemiology
- Global Maternal and Child Health
- Infant Nutrition and Health
- Plant nutrient uptake and metabolism
- Plant and Biological Electrophysiology Studies
- Respiratory Support and Mechanisms
- Plant Pathogens and Resistance
- Ammonia Synthesis and Nitrogen Reduction
- Lipid metabolism and biosynthesis
- Genetic Mapping and Diversity in Plants and Animals
International Flavors & Fragrances (United States)
2025
Pennsylvania State University
2018-2024
University of Canterbury
2021-2022
Anandalok Hospital
2022
ABSTRACT Cyanobacteria are photosynthetic organisms that have garnered significant recognition as potential hosts for sustainable bioproduction. However, their complex regulatory networks pose challenges to major metabolic engineering efforts, thereby limiting feasibility production hosts. Genome streamlining has been demonstrated be a successful approach improving productivity and fitness in heterotrophs but is yet explored its full phototrophs. Here, we present the systematic reduction of...
Understanding how photosynthetic organisms including plants and microbes respond to their environment is crucial for optimizing agricultural practices ensuring food energy security, particularly in the context of climactic change sustainability. This perspective embeds back-of-the-envelope calculations across a organism design scale up workflow. Starting from whole system level, we provide recipe pinpoint key genetic targets, examine logistics detailed computational modeling, explore...
Phototrophic organisms such as cyanobacteria utilize the sun's energy to convert atmospheric carbon dioxide into organic carbon, resulting in diurnal variations cell's metabolism. Flux balance analysis is a widely accepted constraint-based optimization tool for analyzing growth and metabolism, but it generally used time-invariant manner with no provisions sequestering different biomass components at time periods. Here we present CycleSyn, periodic model of Synechocystis sp. PCC 6803...
The growth and development of maize (Zea mays L.) largely depends on its nutrient uptake through the root. Hence, studying growth, response, associated metabolic reprogramming to stress conditions is becoming an important research direction. A genome-scale model (GSM) for root was developed study under nitrogen conditions. reconstructed based available information from KEGG, UniProt, MaizeCyc. Transcriptomics data derived roots hydroponically grown plants were used incorporate regulatory...
Summary Genetic sources of phenotypic variation have been a focus plant studies aimed at improving agricultural yield and understanding adaptive processes. Genome‐wide association identify the genetic background behind trait by examining associations between phenotypes single‐nucleotide polymorphisms (SNPs). Although such are common, biological interpretation results remains challenge; especially due to confounding nature population structure systematic biases thus introduced. Here, we...
Flux balance analysis (FBA) and associated techniques operating on stoichiometric genome-scale metabolic models play a central role in quantifying flows constraining feasible phenotypes. At the heart of these methods lie two important assumptions: (i) biomass precursors energy requirements neither change response to growth conditions nor environmental/genetic perturbations, (ii) metabolite production consumption rates are equal at all times (i.e., steady-state). Despite stringency...
Marine nitrogen-fixing microorganisms are an important source of fixed nitrogen in oceanic ecosystems. The colonial cyanobacterium Trichodesmium and diatom symbionts were thought to be the primary contributors N2 fixation until discovery unusual uncultivated symbiotic UCYN-A (Candidatus Atelocyanobacterium thalassa). has atypical metabolic characteristics lacking oxygen-evolving photosystem II, tricarboxylic acid cycle, carbon-fixation enzyme RuBisCo de novo biosynthetic pathways for a...
This paper reports the fabrication and application of a microfluidic Lab-on-a-Chip platform to study electrotactic movements pathogenic microorganisms. The movement pathogens in response electric fields are one way which they thought locate their hosts. Design platform, associated micro-electronics described. contains arrays micro-electrodes that generate an field defined strength micro-chamber into feed inlet outlet channels for entry exit media To demonstrate applicability motile zoospores...
Nitrogen fixing-cyanobacteria can significantly improve the economic feasibility of cyanobacterial production processes by eliminating requirement for reduced nitrogen. Anabaena sp. ATCC 33047 is a marine, heterocyst forming, nitrogen fixing cyanobacteria with very short doubling time 3.8 h. We developed comprehensive genome-scale metabolic (GSM) model, iAnC892, this organism using annotations and content obtained from multiple databases. iAnC892 describes both vegetative cell types found in...
Abstract Living organisms in analogy with chemical factories use simple molecules such as sugars to produce a variety of compounds which are necessary for sustaining life and some also commercially valuable. The metabolisms (such bacteria) higher plants) alike can be exploited convert low value inputs into high outputs. Unlike conventional factories, microbial production chassis not necessarily tuned single product overproduction. Despite the same end goal, metabolic industrial engineers...
Cyanobacteria are photosynthetic organisms that have garnered significant recognition as potential hosts for sustainable bioproduction. However, their complex regulatory networks pose challenges to major metabolic engineering efforts, thereby limiting feasibility production hosts. Genome streamlining has been demonstrated be a successful approach improving productivity and fitness in heterotrophs but is yet explored its full phototrophs. Here we present the systematic reduction of genome...
Background: Newborn mortality is one of the most neglected health problems in developing world, there are estimated 4 million neonatal deaths worldwide each year. Moreover, it to account for 40% under five and two-third infant deaths.Methods: A descriptive cross-sectional study included 120 primipara mothers newborn from 2 28Day life admitted postnatal ward Siliguri District hospital during year 2022 month June. Data was collected using face interview method.Results: The showed majority were...
The growth and development of maize (Zea mays L.) largely depends on its nutrient uptake through root. Hence, studying growth, response, associated metabolic reprogramming to stress conditions is becoming an important research direction. A genome-scale model (GSM) for the root was developed study under nitrogen-stress condition. reconstructed based available information from KEGG, UniProt, MaizeCyc. Transcriptomics data derived roots hydroponically grown plants used incorporate regulatory...
Abstract Flux balance analysis (FBA) and associated techniques operating on stoichiometric genome-scale metabolic models play a central role in quantifying flows constraining feasible phenotypes. At the heart of these methods lie two important assumptions: (i) biomass precursors energy requirements neither change response to growth conditions nor environmental/genetic perturbations, (ii) metabolite production consumption rates are equal at all times (i.e., steady-state). Despite stringency...