A5035359228- Acute Ischemic Stroke Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracerebral and Subarachnoid Hemorrhage Research
- Intracranial Aneurysms: Treatment and Complications
- Venous Thromboembolism Diagnosis and Management
- Cardiac Arrest and Resuscitation
- Multiple Sclerosis Research Studies
- Cerebrovascular and Carotid Artery Diseases
- Long-Term Effects of COVID-19
- Peripheral Neuropathies and Disorders
- S100 Proteins and Annexins
- Lipoproteins and Cardiovascular Health
- Atrial Fibrillation Management and Outcomes
- COVID-19 Clinical Research Studies
- Stroke Rehabilitation and Recovery
- Antiplatelet Therapy and Cardiovascular Diseases
- SARS-CoV-2 and COVID-19 Research
- Animal Virus Infections Studies
- Cancer, Lipids, and Metabolism
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Platelet Disorders and Treatments
- Trauma Management and Diagnosis
- Alzheimer's disease research and treatments
- Cardiac Ischemia and Reperfusion
- Cardiac Fibrosis and Remodeling
University of Pecs
2016-2025
Uzsoki Hospital
2021
Background Antibodies against gastrointestinal antigens may indicate altered microbiota and immune responses in the gut. Recent experimental data suggest a connection between CNS autoimmunity. Methods gliadin, tissue transglutaminase (t TG ), intrinsic factor ( IF parietal cells PC ) S accharomyces cerevisiae ASCA were screened sera of 45 patients with AQP 4‐seropositive neuromyelitis optica NMO spectrum diseases / ‐ SD 17 4‐seronegative , 85 clinically definite multiple sclerosis MS 48...
Aneurysmal subarachnoid hemorrhage (aSAH) is a serious condition complicated by delayed cerebral ischemia (DCI), where inflammation plays key role. Although altered gut permeability noted in other conditions, its significance aSAH remains unclear. Fatty acid-binding protein (FABP-I), lipopolysaccharide-binding (LBP), and soluble CD-14 (sCD-14) are established markers of barrier dysfunction. This study investigates marker changes early late phases. The included 177 patients 100 controls....
Background: Subarachnoid hemorrhage is a serious condition caused by ruptured intracranial aneurysms, resulting in severe disability mainly young adults. Cerebral vasospasm one of the most common complication subarachnoid hemorrhage; thus, active prevention key to improve prognosis. The glycosylation proteins critical quality attribute which reportedly altered patients diagnosed with acute ischemic stroke. In this study, we examined N-glycosylation profile serum glycoproteins without...
Background: Aneurysmal subarachnoid hemorrhage (aSAH) is a disease associated with high mortality, caused by the rupture of cerebral aneurysm. Decision-support scoring systems used for managing unruptured aneurysms (UIAs) include only radiological parameters related to size and configuration aneurysm, without incorporating blood-based markers. Our aim identify serum marker that shows correlation aneurysm in patients ruptured aneurysms. Methods: Arterial blood samples were collected from who...
Carotid artery stenting with single-layer stents carries a risk of periprocedural cerebral embolization compared to carotid endarterectomy. Dual-layer micromesh were designed for improved plaque coverage and sustained embolic protection. This analysis aimed confirm the Roadsaver dual-layer stent safety in real-world cohort. ROADSAVER was prospective, single-arm, multicenter, observational study. Patients stenosis, eligible elective stenting, enrolled at 52 sites across 13 European countries....
Background: Post-COVID manifestation is defined as persistent symptoms or long-term complications beyond 4 weeks from disease onset. Fatigue and memory impairment are common post-COVID symptoms. We aimed to explore associations between the timeline severity of fatigue anti-SARS-CoV-2 antibodies. Methods: were assessed in a total 101 subjects using Chalder scale (CFQ-11) visual analogue scale. Using bimodal scoring system generated CFQ-11, score ≥4 was severe fatigue. Serum spike (anti-S-Ig)...
The effect of post-vaccination adverse events on immunogenicity is unknown. We aimed to explore relationship between reactions and antibody levels during 6-month follow-up.Blood was serially drawn from healthcare workers after the second dose BNT162b2 mRNA vaccine (Day 12, 30, 60, 90, 120, 150, 180) anti-SARS-CoV-2 spike IgG (S-IgG) were measured. Following each dose, volunteers completed a questionnaire regarding (symptomatic vs. asymptomatic groups).A total 395 subjects received vaccine....
Long COVID is a condition characterized by long-term sequelae persisting after the typical convalescence period of COVID-19. Previous reports have suggested role an unsatisfactory immune response and impaired viral clearance in pathogenesis long syndrome. We focused on potential associations between post-vaccination changes antibody titers severity symptoms factors influencing state remission observed patients with vaccination.The serum anti-SARS-CoV-2 spike (S-Ig) nucleocapsid (NC-Ig)...
Growth differentiation factor 15 (GDF-15), neutrophil gelatinase-associated lipocalin (NGAL), and ADAMTS13 have previously been implicated in the pathophysiological processes of SAH. In present study, we aim to examine their role early period SAH relationship primary secondary outcomes. Serum samples were collected at five time periods after (at 24 h (D1), 72 (D3), 120 (D5), 168 (D7) 216 (D9), post-admission) and) measured by using MILLIPLEX Map Human Cardiovascular Disease (CVD) Magnetic...
The prognosis for patients with aneurysmal subarachnoid hemorrhage (aSAH) is heavily influenced by the development of delayed cerebral ischemia (DCI), but adequate and effective therapy DCI to this day has not been resolved. Multiplex serum biomarker studies may help understand pathophysiological processes underlying DCI. Samples were collected from aSAH at two time points: (1) 24 h (Day 1) (2) 5−7 days after ictus. Serum concentrations eotaxin, FGF-2, FLT-3L, CX3CL1, Il-1b, IL-4, IP-10,...
Long-COVID syndrome is associated with high healthcare costs, but its pathophysiology not yet fully understood. Inflammation, renal impairment or disturbance of the NO system emerge as potential pathogenetic factors. We aimed to investigate relationship between symptoms long-COVID and serum levels cystatin-c (CYSC), orosomucoid (ORM), l-arginine, symmetric dimethylarginine (SDMA) asymmetric (ADMA). A total 114 patients suffering from were included in this observational cohort study. found...
We aimed to investigate the characteristics of serum metabolomics in aneurysmal subarachnoid hemorrhage patients (aSAH) with different 3-month outcomes (good = modified Rankin score: 0-3 vs. poor mRS 4-6). collected samples from 46 aSAH at 24 (D1) and 168 (D7) hours after injury for analysis by liquid chromatography-mass spectrometry. Ninety-six metabolites were identified. Groups compared using multivariate (orthogonal partial least squares discriminant analysis), univariate, receiving...
BackgroundIntracranial hemorrhages (ICH) are classified as symptomatic or asymptomatic according to the presence of clinical deterioration. Here, we aimed find predictive factors intracranial bleeding in a registry-based stroke research.MethodsData consecutive patients with acute ischemic (AIS) were extracted from prospective STAY ALIVE registry. Analysis total population and treatment sugroups such endovascular thrombectomy (EVT), intravenous thrombolysis (IVT), their combination (IVT+EVT)...
Background - Atrial fibrillation (AF) is the most common arrhythmia diagnosed in clinical practice. We aimed to measure L-arginine pathway metabolites as well their ratios patients with different types of AF or sinus rhythm and explore relationship among markers variables subacute phase acute ischemic stroke (AIS). Methods A total 46 AIS were prospectively enrolled. The divided into three groups based on diagnosis either rhythm, paroxysmal permanent AF. Plasma concentration analyzed at...
Objectives Multiple cytokines have been implicated in aneurysmal subarachnoid hemorrhage (aSAH), but tumor necrosis factor superfamily 14 (LIGHT/TNFSF14) and oncostatin-M (OSM) not previously explored. Aims of the Study The primary objective this study was to examine relationship between TNFSF14 OSM levels survival. Our secondary goal investigate a potential association these markers incidence delayed cerebral ischemia (DCI). Materials & Methods We consecutively recruited 60 patients with...
Background: Several factors affect the efficacy of endovascular thrombectomy (EVT); however, anesthesia-related have not been fully explored. We aimed to identify independent predictors outcome by analyzing procedural based on a multicentric stroke registry. Methods: Data consecutive patients with acute ischemic (AIS) were extracted from prospective STAY ALIVE Demographic, clinical, and periprocedural including hemodynamic values analyzed in undergoing either general anesthesia (GA) or...
It is known that adverse reactions following SARS-CoV-2 vaccinations show a positive correlation with the subsequent antibody titer. However, it not clear how booster vaccination are related to levels can be measured after 3rd dose. The primary goal of this study was investigate whether levels.Adverse occurring within 7 days were recorded and anti-SARS-CoV-2 spike protein immunoglobulin (Ig) level in venous blood on post-vaccination 14th, 60th 120th days.A total 218 volunteers included...