A5012286874- Acute Ischemic Stroke Management
- Lignin and Wood Chemistry
- Coal Combustion and Slurry Processing
- Traumatic Brain Injury and Neurovascular Disturbances
- Stroke Rehabilitation and Recovery
- Enhanced Oil Recovery Techniques
- Blood Coagulation and Thrombosis Mechanisms
- Neurological Disease Mechanisms and Treatments
- Protease and Inhibitor Mechanisms
- Cerebrovascular and Carotid Artery Diseases
- Petroleum Processing and Analysis
- Thermochemical Biomass Conversion Processes
AZ Groeninge
2024-2025
Université de Technologie de Compiègne
1995
Resistance to r-tPA (recombinant tissue-type plasminogen activator) is a well-known but poorly understood phenomenon that hampers successful recanalization in patients with acute ischemic stroke. Using clinically relevant thrombi from stroke, we investigated if and how thrombus composition impacts r-tPA-mediated lysis. In addition, explored strategies overcome resistance.
Carotid artery stenting with single-layer stents carries a risk of periprocedural cerebral embolization compared to carotid endarterectomy. Dual-layer micromesh were designed for improved plaque coverage and sustained embolic protection. This analysis aimed confirm the Roadsaver dual-layer stent safety in real-world cohort. ROADSAVER was prospective, single-arm, multicenter, observational study. Patients stenosis, eligible elective stenting, enrolled at 52 sites across 13 European countries....
Background: The optimal acute management of patients with ischemic stroke and a tandem lesion, defined as intracranial large vessel occlusion (LVO) concomitant carotid artery stenosis or occlusion, remains unclear. Our aim is to assess the efficacy safety immediate stenting (CAS) compared delayed in undergoing endovascular treatment (EVT) for due lesions. Study design: CASES phase 3 multicenter prospective randomized open-label blinded endpoint (PROBE) non-inferiority clinical trial....
BACKGROUND: In ischemic stroke due to large vessel occlusion, cerebral blood flow is impaired by thromboemboli, which can originate from various sources in the body. A better understanding of thromboembolus composition improve our underlying pathophysiology and potentially guide improvement prevention strategies. The aim this study therefore was perform a large-sample multi-parameter quantitative histological analysis retrieved thromboemboli patients. METHODS: Thromboemboli (n=501) were...
Achieving first-pass recanalization (FPR) has become the primary procedural objective during thrombectomy in acute ischemic stroke patients as it correlates with best clinical outcome. Understanding factors contributing to FPR failures is essential enhance success rates. As central target of thrombectomy, thrombus itself may be a significant factor influencing FPR.