A5053339079- Zebrafish Biomedical Research Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Stress Responses and Cortisol
- Adenosine and Purinergic Signaling
- Tryptophan and brain disorders
- Immune cells in cancer
- Neuroscience and Neuropharmacology Research
- Radiopharmaceutical Chemistry and Applications
- Immune Response and Inflammation
- Prenatal Substance Exposure Effects
- Cannabis and Cannabinoid Research
- Peptidase Inhibition and Analysis
- Sleep and Wakefulness Research
- Cancer Immunotherapy and Biomarkers
- Natural product bioactivities and synthesis
- Infective Endocarditis Diagnosis and Management
- Innovative Microfluidic and Catalytic Techniques Innovation
- Nuclear Receptors and Signaling
- Parkinson's Disease Mechanisms and Treatments
- Neuroendocrine Tumor Research Advances
- Antimicrobial Resistance in Staphylococcus
- Medicinal plant effects and applications
- Birth, Development, and Health
- Neurogenesis and neuroplasticity mechanisms
- Neonatal Respiratory Health Research
University of Groningen
2020-2024
University Medical Center Groningen
2020-2024
Imaging Center
2022
Pontifícia Universidade Católica do Rio Grande do Sul
2011-2022
Instituto Nacional de Ciência e Tecnologia Translacional em Medicina
2012
Bacterial infections are a major problem in medicine, and the rapid accurate detection of such is essential for optimal patient outcome. can be diagnosed by nuclear imaging, but most currently available modalities unable to discriminate infection from sterile inflammation. Bacteria-targeted positron emission tomography (PET) tracers have potential overcome this hurdle. In present study, we compared three
Although proton therapy is increasingly being used in the treatment of paediatric and adult brain tumours, there are still uncertainties surrounding biological effect protons on normal brain. Microglia, brain-resident macrophages, have been shown to play a role development radiation-induced neurotoxicity. However, their molecular hence functional response irradiation remains unknown. This study investigates microglia by comparing photons as well influence age different irradiated volumes.
The development of very fast, clean, and selective methods for indirect labeling in PET tracer synthesis is an ongoing challenge. Here we present the ultrafast photoclick method short-lived 18F-PET tracers based on photocycloaddition reaction 9,10-phenanthrenequinones with electron-rich alkenes. respective precursors are synthetically easily accessible can be functionalized various target groups. Using a flow photo-microreactor, performed 60 s, clinically relevant prostate cancer bacterial...
FAP-targeted radiopharmaceuticals represent a breakthrough in cancer imaging and viable option for therapeutic applications. OncoFAP is an ultra-high-affinity ligand of FAP with dissociation constant 680 pM. has been recently discovered clinically validated PET procedures patients solid malignancies. While more clinical validation becoming available, the need scalable robust preparation this new class continues to increase. In article, we present development automated radiolabeling...
Abstract Introduction Depression is characterized by behavioral, cognitive and physiological changes, imposing a major burden on the overall wellbeing of patient. Some evidence indicates that social stress, changes in growth factors (e.g., brain-derived neurotrophic factor (BDNF)), neuroinflammation are involved development progression disease. The monoamine oxidase A inhibitor drug harmine was suggested to have both antidepressant anti-inflammatory properties may, therefore, be potential...
Abstract Hyperargininemia is an inborn error of metabolism (IEM) characterized by tissue accumulation arginine (Arg). Mental retardation and other neurological features are common symptoms in hyperargininemic patients. Considering purinergic signaling has a crucial role from the early stages development underlying mechanisms this disease poorly established, we investigated effect Arg administration on locomotor activity, morphological alterations, extracellular nucleotide hydrolysis larvae...
Worldwide, millions of people suffer from treatment-resistant depression. Ketamine, a glutamatergic receptor antagonist, can have rapid antidepressant effect even in patients. A proposed mechanism for the ketamine is reduction neuroinflammation. To further explore this hypothesis, we investigated whether single dose modulate protracted neuroinflammation repeated social defeat (RSD) stress rat model, which resembles features end, male animals exposed to RSD were injected with (20 mg/kg) or...
Abstract FAP-targeted radiopharmaceuticals represent a breakthrough in cancer imaging and viable option for therapeutic applications. OncoFAP, an ultra-high affinity ligand of FAP, has been recently discovered clinically validated PET procedures patients with solid malignancies. While more clinical validation is becoming available, the need scalable robust preparation this new class continues to increase. In article, we present development automated radiolabelling FASTlab 2 OncoFAP-based...
Most pharmacological treatments for depression target monoamine transporters and about 50 % of treated patients attain symptomatic remission. Once remission is attained, it hard to distinguish the changes on brain monoaminergic transmission induced by antidepressants, from those associated per se. In this study, we aimed at studying spontaneously remitted rats repeated social defeat (RSD)-induced in terms dopamine D
Summary More than half of all brain tumour survivors experience debilitating and often progressive cognitive decline after treatment with radiotherapy. Microglia, the resident macrophages in brain, have been implicated this decline. In response to various insults microglia can develop innate immune memory (IIM), which either enhance (priming) or repress (tolerance) subsequent inflammatory challenges. Here, we investigated whether radiation affects IIM by irradiating brains rats later...