A5085968349- Drug Transport and Resistance Mechanisms
- Medical Imaging Techniques and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neuropharmacology Research
- Parkinson's Disease Mechanisms and Treatments
- Stress Responses and Cortisol
- Plasma Applications and Diagnostics
- Tissue Engineering and Regenerative Medicine
- Immune cells in cancer
- 3D Printing in Biomedical Research
- Drug-Induced Hepatotoxicity and Protection
- Chemokine receptors and signaling
- Neuropeptides and Animal Physiology
- Glycosylation and Glycoproteins Research
- Electrochemical sensors and biosensors
- Fire dynamics and safety research
- Animal testing and alternatives
- Cholinesterase and Neurodegenerative Diseases
- Medical Malpractice and Liability Issues
- Neurological diseases and metabolism
- Cardiac Fibrosis and Remodeling
- Radiopharmaceutical Chemistry and Applications
- Alzheimer's disease research and treatments
- Advanced Radiotherapy Techniques
University of Rostock
2021-2024
University of Groningen
2018-2020
University Medical Center Groningen
2018-2020
University of British Columbia
2018-2020
University Medical Center Hamburg-Eppendorf
2014
Universität Hamburg
2014
Metastasis formation is the major reason for extremely poor prognosis in small cell lung cancer (SCLC) patients. The molecular interaction partners regulating metastasis SCLC are largely unidentified, however, from other tumor entities it known that cells use adhesion molecules of leukocyte cascade to attach endothelium at site future metastasis. Using human OH-1 line as a model, we found these expressed E- and P-selectin binding sites, which could be part attributed selectin carbohydrate...
(Background) Aim of this retrospective analysis was to investigate in mCRPC patients treated with [177Lu]Lu-PSMA-617 whether the absorbed dose (AD) organs at risk (OAR, i.e., kidneys and parotid glands) can be calculated using simplified methodologies sufficient accuracy. For calculation, results kinetics first therapy cycle were used. (Methods) 46 2 6 cycles included. As reference (current clinical standard) full dosimetry OAR based on quantitative imaging (whole body scintigraphy SPECT/CT...
The initial idea of functional tissue replacement has shifted to the concept that injected cells positively modulate myocardial healing by a non-specific immune response transplanted within target tissue. This alleged local modification scar requires assessment regional properties left ventricular wall in addition commonly applied measures global morphological and parameters. Hence, we aimed at investigating effect cardiac cell therapy with cardiovascular progenitor cells, so-called induced...
Background: Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common genetic risk factor for Parkinson’s disease (PD). While corresponding pathogenic mechanisms remain largely unknown, LRRK2 has been implicated in immune system. Objective: To assess whether alter t he sensitivity to a single peripheral inflammatory trigger, with ultimate impact on dopaminergic integrity, using longitudinal imaging-based study design. Methods: Rats carrying p.G2019S and non-transgenic (NT)...
Abstract Introduction Depression is characterized by behavioral, cognitive and physiological changes, imposing a major burden on the overall wellbeing of patient. Some evidence indicates that social stress, changes in growth factors (e.g., brain-derived neurotrophic factor (BDNF)), neuroinflammation are involved development progression disease. The monoamine oxidase A inhibitor drug harmine was suggested to have both antidepressant anti-inflammatory properties may, therefore, be potential...
In longitudinal PET studies, animals are repeatedly anesthetized which may affect the repeatability of measurements. The aim this study was to assess effect anesthesia on P-gp function as well reproducibility [18F]MC225 scans. Thus, dynamic scans with blood sampling were conducted in 13 Wistar rats. Seven exposed isoflurane 1 week before scan ("Anesthesia-exposed" PET). A second group six used evaluate measurements at blood–brain barrier (BBB) [18F]MC225. group, two made a interval ("Test"...
Skin cancer is the most frequent worldwide and divided into non-melanoma skin cancer, including basal cell carcinoma, as well squamous carcinoma (SCC) malignant melanoma (MM).
Obesity is characterized by immoderate fat accumulation leading to an elevated risk of neurodegenerative disorders, along with a host metabolic disturbances. Chronic neuroinflammation main factor linking obesity and the propensity for disorders. To determine cerebrometabolic effects diet-induced (DIO) in female mice fed long-term (24 weeks) high-fat diet (HFD, 60% fat) compared group on control (CD, 20% fat), we used vivo PET imaging radiotracer [18F]FDG as marker brain glucose metabolism....
Animal models are crucial to preclinical oncological research and drug development. experiments must be performed in accordance with the 3R principles of replacement reduction, if possible, refinement where these procedures remain crucial. In addition, European Union legislations demand a continuous approach, as well pro- retrospective severity assessment. this study, an objective databased assessment was murine for pancreatic cancer induced by orthotopic, subcutaneous, or intravenous...
Abstract Clinical imaging techniques such as positron emission tomography (PET) in combination with computed (CT) are increasingly being used biomedical research involving small animal models. The handling of open radioactive substances (radiopharmaceuticals) necessary for PET requires prior official authorization handling, the application radiation protection principles, and regular training. overriding aim is to protect personnel directly involved, other persons, environment from harmful...
The interaction of dopaminergic and cholinergic neurotransmission in, e.g., Parkinson's disease has been well established. Here, D2 receptor antagonists were used to assess changes in [18F]-FEOBV binding the vesicular acetylcholine transporter (VAChT) rodents using positron emission tomography (PET). After pretreatment with either 10 mg/kg haloperidol, 1 raclopride, or vehicle, 90 min dynamic PET scans performed arterial blood sampling. net influx rate (Ki) was obtained from Patlak graphical...