A5076717426- Neuroinflammation and Neurodegeneration Mechanisms
- Acute Ischemic Stroke Management
- Atherosclerosis and Cardiovascular Diseases
- Neurological Disease Mechanisms and Treatments
- Drug Transport and Resistance Mechanisms
- Cerebral Palsy and Movement Disorders
- Balance, Gait, and Falls Prevention
- Nanoparticle-Based Drug Delivery
- Long-Term Effects of COVID-19
- Intracerebral and Subarachnoid Hemorrhage Research
- Pharmacological Effects and Toxicity Studies
- Immune cells in cancer
- Rheumatoid Arthritis Research and Therapies
- Nanoplatforms for cancer theranostics
- Hip and Femur Fractures
- Bone health and osteoporosis research
- Systemic Lupus Erythematosus Research
- Pelvic and Acetabular Injuries
- Cell Adhesion Molecules Research
- Ultrasound and Hyperthermia Applications
- Chronic Disease Management Strategies
- Neurosurgical Procedures and Complications
- Scoliosis diagnosis and treatment
- Autoimmune and Inflammatory Disorders Research
- Immunodeficiency and Autoimmune Disorders
Institut Universitari d'Investigació en Atenció Primària Jordi Gol
2024
Universidade de Santiago de Compostela
2022-2023
Center for Research in Molecular Medicine and Chronic Diseases
2022-2023
University of Almería
2023
Instituto de Investigación Sanitaria de Santiago
2019-2021
Creative Commons
2020
University of Puerto Rico-Mayaguez
2020
Weatherford College
2019-2020
Complejo Hospitalario Universitario de Santiago
2019-2020
Institut Català de la Salut
2019
Recent preclinical studies have shown that regulatory T cells (Treg) play a key role in the immune response after ischemic stroke (IS). However, of Treg human acute IS has been poorly investigated. Our aim was to study relationship between circulating and outcome patients.A total 204 patients 22 control subjects were recruited. The main variable good functional at 3 months (modified Rankin scale ≤2) considering infarct volume, Early Neurological Deterioration (END) risk infections as...
Background The neurological symptoms of Long COVID (LC) and the impact neuropsychological manifestations on people’s daily lives have been extensively described. Although a large body literature describes symptoms, validating this with objective measures is important. This study aims to identify describe effects cognition, balance, retinal fundus, determine whether duration influences cognitive impairment. Methods cross-sectional involved LC volunteers complaint from public health centers in...
There is a growing interest in the effect of Long-COVID (LC) on cognition, and neuroimaging allows us to gain insight into structural functional changes underlying cognitive impairment LC. We used multimodal data combination with neuropsychological evaluations study complaints cohort LC patients mild moderate severity symptoms.
The ligands 2,4,6-tris(4-methylpyrazol-1-yl)-1,3,5-triazine (Me-TPzT), 2,4,6-tris(4-bromopyrazol-1-yl)-1,3,5-triazine (Br-TPzT), and 2-methoxy-4,6-bis(4-methylpyrazol-1-yl)-1,3,5-triazine (Me-BPzTOMe) have been synthesized their reactions with some palladium derivatives explored. fragment [Pd(eta(3)-2-Me-C(3)H(4))(S)(2)](+), S = acetone, reacts in acetone Me-TPzT or Br-TPzT a 3:1 molar ratio to generate new complexes which two allylpalladium fragments are present the TPzT partially...
gamification is a potentially attractive option for improving balance and reducing falls. to assess the effect of training using NintendoTM Wii game console on (primary outcome), falls fear falling. quasi-randomised, open-label, controlled clinical trial in parallel groups, carried out community-dwelling patients over 70 years, able walk independently. Participants were assigned 1:1 intervention or control group. Balance was conducted Nintendo WiiFitTM twice week 3 months. assessed Tinetti...
Ischemic stroke is the most common cerebrovascular disease and caused by interruption of blood supply to brain. To date, recombinant tissue plasminogen activator (rtPA) has been main pharmacological treatment in acute phase. However, this some drawbacks, such as a short half-life, low reperfusion rate, risk hemorrhagic transformations, neurotoxic effects. overcome limitations rtPA improve its effectiveness, we recently designed sonosensitive sub-micrometric capsules (SCs) loaded with size...
The synthesis of nanosized metal–organic frameworks (NMOFs) is requisite for their application as injectable drug delivery systems (DDSs) and other biorelevant purposes.
Identifying the complexities of effect sex on stroke risk, etiology, and lesion progression may lead to advances in treatment care ischemic (IS) non-traumatic intracerebral hemorrhage patients (ICH). We studied sex-related discrepancies clinical course with IS ICH, we also evaluated possible molecular mechanisms involved. The study's main variable was patient's functional outcome at 3-months. Logistic regression models were used order study influence different inflammatory, endothelial...
Balance alteration is a risk factor for falls in elderly individuals that has physical, psychological and economic consequences. The objectives of this study are to evaluate the usefulness an intervention utilizing Nintendo™ Wii console order improve balance, thereby decreasing both fear falling as well number falls, correlation between balance determined by value obtained Tinetti tests one foot stationary test.This controlled, randomized clinical trial individual assignment, carried out on...
P-Glycoprotein (P-gp) is an efflux pump located at the blood–brain barrier (BBB) that contributes to protection of central nervous system by transporting neurotoxic compounds out brain. A decline in P-gp function has been related pathogenesis neurodegenerative diseases. inducers can increase and are considered as potential candidates for treatment such disorders. The inducer MC111 increased expression SW480 human colon adenocarcinoma colo-320 cells, respectively. Our study aims evaluate...
In longitudinal PET studies, animals are repeatedly anesthetized which may affect the repeatability of measurements. The aim this study was to assess effect anesthesia on P-gp function as well reproducibility [18F]MC225 scans. Thus, dynamic scans with blood sampling were conducted in 13 Wistar rats. Seven exposed isoflurane 1 week before scan ("Anesthesia-exposed" PET). A second group six used evaluate measurements at blood–brain barrier (BBB) [18F]MC225. group, two made a interval ("Test"...
Intracerebral hemorrhage (ICH), being the most severe cerebrovascular disease, accounts for 10–15% of all strokes. Hematoma expansion is one important factors associated with poor outcome in intracerebral (ICH). Several studies have suggested that an "ischemic penumbra" might arise when hematoma has a large expansion, but clinical are inconclusive. We performed preclinical study to demonstrate presence hypoxic–ischemic tissue around by means longitudinal [18F]-fluoromisonidazole...
The sustained use of intraoperative fluoroscopy has led to increased minimally invasive surgical techniques, enhanced surgeon proficiency, improved anatomic corrections, reduced patient morbidity, earlier functional recovery, and decreased length hospital stay. As a result, orthopedic attending surgeons residents are exposed more radiation, increasing the risk cancer radiation-induced cataracts compared with general population those who work in other specialties. magnitude radiation exposure...
Abstract Background: Recent preclinical studies have shown that regulatory T (Treg) cells play a key role in the immune response after ischemic stroke (IS). However, of Treg-cells human acute IS has been poorly investigated. Our aim was to study relationship between circulating and outcome patients.Methods Methods: A total 204 patients 22 control subjects were recruited. The main variable good functional at 3 months (modified Rankin scale ≤2) considering infarct volume, Early Neurological...
Introduction: Demographic and socioeconomic factors are important determinants that may affect patient self-reported outcomes after acetabular fracture surgery. Hispanics, as a minority group, have an increased tendency to suffer demographic disparities. At the present time, there is scant information regarding their role among Hispanic patients with fractures. The aim of this study was investigate whether or would satisfaction functional in who endured open reduction internal fixation...
<h3>Objectives</h3> To determine the features of patients referred to case management and from process at Regional University Hospital in Malaga. <h3>Methods</h3> <i>Design:</i> Descriptive cross-sectional study. Patients: treated Rheumatology service Malaga April November 2013. The model is created as a response need for greater efficiency care due new Socio-medical Syndrome situation caused by ageing population, increase frail home care. begins with rheumatologist identifying problem be...
<h3>Objectives</h3> To evaluate the trabecular bone score (TBS) in patients with systemic lupus erythematosus (SLE). <h3>Methods</h3> Design: Cross sectional study. Patients: we recruited 37 SLE who had at least one DXA and analysis of microarchitecture during follow-up. Protocol: analysed most recent DXA, TBS clinical data collected from records using a predesigned questionnaire. Variables: demographic, therapeutic (including use glucocorticoids antiresorptives), laboratory features...
<h3>Objectives</h3> To analyse if using risk indices and PIXI scans jointly would reduce requirement for central DEXA to diagnose postmenopausal OP. <h3>Methods</h3> A stratified sample of women was selected: a random 305 from Primary care, 200 consecutive referred DXA measurement tertiary care. Inclusion criteria: Caucasian female, age ≥50 yrs, full menopause (amenorrhea ≥12 mo.). Exclusion previous OP, treatment with OP drugs (calcium and/or vitamin D estrogens menopausal symptoms were...