A5103261837- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- Cardiac Fibrosis and Remodeling
- Prostate Cancer Treatment and Research
- Tissue Engineering and Regenerative Medicine
- Cancer, Hypoxia, and Metabolism
- Radiation Dose and Imaging
- Effects of Radiation Exposure
- Pancreatic and Hepatic Oncology Research
- 3D Printing in Biomedical Research
- Multiple Sclerosis Research Studies
- Drug-Induced Hepatotoxicity and Protection
- Monoclonal and Polyclonal Antibodies Research
- Metabolism, Diabetes, and Cancer
- Chemokine receptors and signaling
- Chemical Reactions and Isotopes
- Signaling Pathways in Disease
- Radiomics and Machine Learning in Medical Imaging
- Animal testing and alternatives
- Peptidase Inhibition and Analysis
- Veterinary Pharmacology and Anesthesia
- Advanced Radiotherapy Techniques
- Cell Adhesion Molecules Research
- Immunotherapy and Immune Responses
- Sphingolipid Metabolism and Signaling
University of Rostock
2020-2024
Universitätsmedizin Rostock
2020-2021
Klinik und Poliklinik für Nuklearmedizin
2021
Despite the recent success of prostate-specific membrane antigen (PSMA)-targeted compounds for theranostic use in prostate cancer (PCa), alternative options detection and treatment PSMA-negative lesions are needed. We have recently developed a novel gastrin-releasing peptide receptor (GRPR) ligand with improved metabolic stability, which might improve diagnostic therapeutic efficacy could be valuable PCa patients. Our aim was to examine its suitability use. performed comparative preclinical...
Multiple sclerosis (MS), an autoimmune-driven, inflammatory demyelinating disease of the central nervous system (CNS), causes irreversible accumulation neurological deficits to a variable extent. Although there are potent disease-modifying agents for its initial relapsing–remitting phase, immunosuppressive therapies show limited efficacy in secondary progressive MS (SPMS). modulation sphingosine-1 phosphate receptors has proven beneficial during SPMS, underlying mechanisms poorly understood....
Pancreatic cancer is the fourth leading cause of death, with a 5-year survival rate 10%. A stagnant high mortality over last decades highlights need for innovative therapeutic approaches. tumors pursue an altered metabolism in order to maintain energy generation under low nutrient influx and hypoxic conditions. Targeting these metabolic strategies might therefore be reasonable approach pancreatic cancer. One promising agent CPI- 613, potent inhibitor two enzymes tricarboxylic acid cycle. The...
The initial idea of functional tissue replacement has shifted to the concept that injected cells positively modulate myocardial healing by a non-specific immune response transplanted within target tissue. This alleged local modification scar requires assessment regional properties left ventricular wall in addition commonly applied measures global morphological and parameters. Hence, we aimed at investigating effect cardiac cell therapy with cardiovascular progenitor cells, so-called induced...
Angiogenesis plays a central role in the healing process following acute myocardial infarction. The PET tracer [68Ga]-NODAGA-RGD, which is ligand for αvβ3 integrin, has been investigated imaging angiogenesis of myocardium both animal and clinical studies. It´s value as prognostic marker functional outcome remains unclear. Therefore, aim this work was to establish [68Ga]-NODAGA-RGD murine infarct model evaluate predictor cardiac remodeling context stem cell therapy. performed seven days after...
Animal models are crucial to preclinical oncological research and drug development. experiments must be performed in accordance with the 3R principles of replacement reduction, if possible, refinement where these procedures remain crucial. In addition, European Union legislations demand a continuous approach, as well pro- retrospective severity assessment. this study, an objective databased assessment was murine for pancreatic cancer induced by orthotopic, subcutaneous, or intravenous...
Abstract Clinical imaging techniques such as positron emission tomography (PET) in combination with computed (CT) are increasingly being used biomedical research involving small animal models. The handling of open radioactive substances (radiopharmaceuticals) necessary for PET requires prior official authorization handling, the application radiation protection principles, and regular training. overriding aim is to protect personnel directly involved, other persons, environment from harmful...
Abstract The development of radiometal‐labelled pharmaceuticals for neuroimaging could offer great potential due to easier handling during labelling and availability through radionuclide generator systems. Nonetheless, date, no such tracers are available positron emission tomography, primarily owing the challenge crossing blood–brain barrier (BBB) loss affinity chelator attachment. We have prepared a variety 68 Ga‐labelled phenyltropanes showing that, simple hydrocarbon‐linker, it is...
Ziel/Aim In prostate cancer (PC) the development and evaluation of novel targeted therapies play an emerging role potentially improving outcome. Multimodal imaging for therapy response assessment (TRA) these new drugs is a promising tool to evaluate efficacy. Herein we in-vivo efficacy indolylmaleimide PDA-66 using small animal F-18 FDG, FLT PET/CT MRI in PC-3 human PC xenograft mouse model. Anti-tumoral effects were demonstrated in-vitro previously.
Zusammenfassung Der Chemokinrezeptor CXCR4 – häufig nachgewiesen, doch selten greifbar. Während in einer schier endlosen Zahl an Studien seine physiologische und pathogene Präsenz, zellulären Funktionen sowie Möglichkeiten seiner gezielten pharmakologischen Kontrolle seit fast 30 Jahren erforscht werden, ist das Spektrum nuklearmedizinischen klinischen Anwendungen mit malignen Krankheitsbildern des hämatopoetischen Systems einigen wenigen Entzündungsprozessen immer noch überschaubar. Das...