A5068335188- Salmonella and Campylobacter epidemiology
- MicroRNA in disease regulation
- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Gut microbiota and health
- Circular RNAs in diseases
- Glycosylation and Glycoproteins Research
- Clostridium difficile and Clostridium perfringens research
- Cancer-related molecular mechanisms research
- Plant Disease Resistance and Genetics
- Pharmacological Effects and Toxicity Studies
- GDF15 and Related Biomarkers
- Plant and Fungal Interactions Research
- Consumer Retail Behavior Studies
- Molecular Biology Techniques and Applications
- Amoebic Infections and Treatments
- Mycorrhizal Fungi and Plant Interactions
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pharmacological Effects and Assays
- Yersinia bacterium, plague, ectoparasites research
- Enzyme Production and Characterization
- Hemoglobinopathies and Related Disorders
- Bacterial Identification and Susceptibility Testing
- Iron Metabolism and Disorders
- Diet and metabolism studies
University of Manchester
2015-2024
Kaiser Permanente San Francisco Medical Center
2023
Central Michigan University
2015
Virginia Commonwealth University
2012-2015
George Mason University
2012
MicroRNAs (miRs) are a novel class of small RNA molecules, the dysregulation which can contribute to cancer. A combinatorial approach was used identify miRs that promote prostate cancer progression in unique set cell lines, originate from parental p69 line and extend highly tumorigenic/metastatic M12 subline. Together, these lines thought mimic vivo. Previous network analysis miR arrays suggested loss hsa-miR-125b together with overexpression hsa-miR-22 could tumorigenesis. The two confirmed...
This study is focused on the rapid differentiation of multiple<italic>Campylobacter</italic>species down to sub-species level, which may provide critical information and knowledge risk factors, virulence, distribution these major foodborne pathogens.
Abstract Background Amplicon-based mycobiome analysis has the potential to identify all fungal species within a sample and hence could provide valuable diagnostic assay for use in clinical mycology settings. In last decade, been increasingly characterised by targeting internal transcribed spacer (ITS) regions. Although ITS targets give broad coverage high sensitivity, they fail accurate quantitation as copy number of regions genomes is highly variable even species. To address these issues,...
This review summarises the characteristics of lung mycobiome in patients with chronic respiratory diseases and fungal diseases. We have also reviewed limitations current methods studies. Available studies impacts are scarce comparison available is hindered by heterogeneity sample sizes, patient selection. The impact diversity composition poorly understood. Most involve detection fungi samples culture. However, such lack sensitivity emergence next-generation sequencing technologies an...
The RNA interference (RNAi) pathway has evolved numerous functionalities in eukaryotes, with many on display Kingdom Fungi. RNAi can regulate gene expression, facilitate drug resistance, or even be altogether lost to improve growth potential some fungal pathogens. In the WHO priority pathogen,
microRNAs (miRNAs) are small RNAs shown to contribute a number of cellular processes including cell growth, differentiation, and apoptosis. MiRNAs regulate gene expression their targets post-transcriptionally by binding messenger RNA (mRNA), causing translational inhibition or mRNA degradation. Dysregulation miRNA can promote cancer formation progression. Research has largely focused on the function single miRNAs. However, complex physiological require interaction, regulation coordination...
Coronavirus disease 2019 (COVID-19)-associated pulmonary aspergillosis (CAPA) is a life-threatening complication in patients with severe COVID-19. Previously, acute respiratory distress syndrome COVID-19 has been associated lung fungal dysbiosis, evidenced by reduced microbial diversity and
Campylobacter fetus is commonly associated with venereal disease and abortions in cattle sheep, can also cause intestinal or systemic infections humans that are immunocompromised, elderly, exposed to infected livestock. It believed C. infection result from the consumption handling of contaminated food products, but rarely detected since isolation methods not suited for its detection physiology organism makes culturing difficult. In related species, jejuni, ability colonize host has been...
Despite the lack of agreement on their exact roles, it is known that miRNAs contribute to cancer progression. Many studies utilize methods detect differential regulation miRNA expression. It prohibitively expensive examine all potentially dysregulated and traditionally, researchers have focused efforts most extremely miRNAs. These may overlook contribution less differentially expressed but more functionally relevant The purpose this study was outline a method not only utilizes expression...
Abstract Rationale COVID-19-associated pulmonary aspergillosis (CAPA) is a life-threatening complication in patients with severe COVID-19. Previously, acute respiratory distress syndrome COVID-19 has been associated lung fungal dysbiosis, evidenced by reduced microbial diversity and Candida colonisation. Increased burden the lungs of critically ill linked to prolonged mechanical ventilation increased mortality. However, specific mycobiome signatures context survival antifungal drug...
A single bout of exercise (EX) can have benefits on glucose metabolism in both normal and insulin-resistant individuals. Several plasma proteins secreted by muscle other tissues been demonstrated to roles regulating energy including irisin, brain-derived neurotrophic factor (BDNF), fibroblast growth factor-21 (FGF-21). However the effect circulating levels these proteins, after an acute a model dietary-induced insulin resistance is not known. Rats (male Sprague-Dawley, ~9-mos old) were fed...
Abstract Purpose Studies have shown the positive impact pharmacist-managed services on patient care. However, little information is available for pregnant patients. This study contributes to current literature by providing data of a service outcomes in patients with iron-deficiency anemia. Methods was retrospective, data-only, multicenter comparing anemia managed pharmacist (n = 100) those who received standard care 100). During period, were 16 years age or older and concurrent The...
Abstract MicroRNAs (miRs) are small molecules that post-transcriptionally regulate expression of target mRNAs and thought to play a major role in prostate cancer (CaP) tumorigenesis. We compared miR progressive cell model consisting the immortalized p69 human line M12, highly tumorigenic, metastatic subline, F6, weakly tumorigenic variant using Exiqon's miRCURY LNA™ panels. Most notable was decrease miR-125b miR-17-3p, which confirmed by single analysis via RT-qPCR. Previously, array screens...
ABSTRACT The RNA interference (RNAi) pathway has evolved numerous functionalities in eukaryotes, with many on display Kingdom Fungi. RNAi can regulate gene expression, facilitate drug resistance, or even be altogether lost to improve growth potential some fungal pathogens. In the WHO priority pathogen, Aspergillus fumigatus , system is known intact and functional. To extend our limited understanding of A. RNAi, we first investigated genetic variation RNAi-associated genes a collection 217...