A5089815973- Mycobacterium research and diagnosis
- Cardiac Valve Diseases and Treatments
- Tuberculosis Research and Epidemiology
- CAR-T cell therapy research
- Cardiomyopathy and Myosin Studies
- Cardiac Imaging and Diagnostics
- Diagnosis and treatment of tuberculosis
- Congenital Heart Disease Studies
- Coronary Interventions and Diagnostics
- Chemotherapy-induced cardiotoxicity and mitigation
- Atrial Fibrillation Management and Outcomes
- Mechanical Circulatory Support Devices
- Glioma Diagnosis and Treatment
- Infectious Diseases and Tuberculosis
- Advancements in Semiconductor Devices and Circuit Design
- Erythrocyte Function and Pathophysiology
- Perfectionism, Procrastination, Anxiety Studies
- Takotsubo Cardiomyopathy and Associated Phenomena
- Cardiovascular Function and Risk Factors
- Cardiac electrophysiology and arrhythmias
- Ion channel regulation and function
- Infective Endocarditis Diagnosis and Management
- Pericarditis and Cardiac Tamponade
- PARP inhibition in cancer therapy
- Cardiac Structural Anomalies and Repair
Emory University
2024
University of South Florida
2019-2024
Tampa General Hospital
2024
Indian Veterinary Research Institute
2024
Apollo Proton Cancer Centre
2024
Johns Hopkins All Children's Hospital
2024
Johns Hopkins University
2024
International Society for Heart and Lung Transplantation
2024
IFC Research (United Kingdom)
2024
Moffitt Cancer Center
2019-2023
Abstract Background Chimeric antigen receptor T- Cell (CAR-T) immunotherapy has been a breakthrough treatment for various hematological malignancies. However, cardiotoxicities such as new-onset heart failure, arrhythmia, acute coronary syndrome and cardiovascular death occur in 10–15% of patients treated with CAR-T. This study aims to investigate the changes cardiac inflammatory biomarkers CAR-T therapy determine role pro-inflammatory cytokines. Methods In this observational study, ninety...
Abstract Cardiomyopathy is a progressive disease of the myocardium leading to impaired contractility. Genotoxic cancer therapies are known be potent drivers cardiomyopathy, whereas causes spontaneous remain unclear. To test hypothesis that endogenous genotoxic stress contributes we deleted DNA repair gene Ercc1 specifically in striated muscle using floxed allele and mice expressing Cre under control muscle‐specific creatinine kinase ( Ckmm ) promoter or depleted systemically −/D mice)....
Abstract Idecabtagene vicleucel (ide-cel) is a type of B-cell maturation antigen (BCMA)–targeting chimeric receptor T-cell (CAR-T) approved for the treatment relapsed and refractory multiple myeloma (RRMM). Currently, incidence cardiac events associated with ide-cel remains unclear. This was retrospective single-center observational study patients treated RRMM. We included all consecutive who received standard-of-care at least 1-month follow-up. Baseline clinical risk factors, safety...
Background Percutaneous Hepatic Perfusion (PHP) is a liver directed regional therapy recently FDA approved for metastatic uveal melanoma to the involving percutaneous isolation of liver, saturation entire with high-dose chemotherapy and filtration extracorporeally though in line filters veno-venous bypass. The procedure associated hemodynamic shifts requiring support blood product resuscitation due coagulopathy. Objective To assess cardiac safety subsequent clinically significant sequalae...
Undifferentiated spondyloarthropathy (USpa) may either represent a forme fruste of other spondyloarthropathies like reactive arthritis or be different disease entity. To study the link between USpa and arthritis, we studied presence IgA antibodies to Yersinia enterocolitica, Salmonella typhimurium, Shigella flexneri, Campylobacter jejuni Chlamydia trachomatis in sera from 14 patients with (European Spondyloarthropathy Study Group criteria) using ELISA. Escherichia coli was used as control...
Adoptive cellular therapy (ACT) with tumor-infiltrating lymphocytes (TILs) has emerged as an effective treatment option for unresectable stage III/IV metastatic melanoma. Acute toxicities, particularly cardiovascular (CV), can have a significant effect on the completion of therapy. We abstracted information 43 patients who received ACT-TIL melanoma at Moffitt Cancer Center between 2010 and 2016. The Student t tests χ 2 were used to compare patient characteristics by presence versus absence...
Guinea pigs were injected with spheroplasts of Mycobacterium tuberculosis and sacrificed after various intervals to study the state organisms evaluate extent disease. The persisted in body animals for a considerable length time. Their presence, however, was not associated either development tuberculin hypersensitivity or pathologic changes. It found that pathogenic only when reverted bacterial forms. reversion bacillary subsequent initiation infection dependent on duration their stay within host.
Transcatheter aortic valve replacement (TAVR) for severe stenosis (AS) is an increasingly prevalent treatment in patients who are intermediate or high risk surgical intervention. In nonagenarian undergoing TAVR, symptomatic relief and quality of life (QoL) outcomes have not been well established. This study explores these this patient population that has underrepresented landmark clinical trials.
<h3>Background</h3> Susceptibility of microorganisms to antibiotics is clearly decreasing in many Asian countries and particular concern <i>Streptococcus pneumoniae</i>. The genetic relationship between penicillin-resistant <i>S pneumoniae</i> strains from across Asia suggests that resistant clones have spread within countries. <h3>Purpose</h3> study was designed determine the susceptibility respiratory by using antibiogram reports. <h3>Materials methods</h3> bacterial were isolated patients...